52results about How to "Easy manipulation" patented technology

Structures and methods for tissue engineering include a multicellular body including a plurality of living cells. A plurality of multicellular bodies can be arranged in a pattern and allowed to fuse to form an engineered tissue. The arrangement can include filler bodies including a biocompatible material that resists migration and ingrowth of cells from the multicellular bodies and that is resistant to adherence of cells to it. Three-dimensional constructs can be assembled by printing or otherwise stacking the multicellular bodies and filler bodies such that there is direct contact between adjoining multicellular bodies, suitably along a contact area that has a substantial length. The direct contact between the multicellular bodies promotes efficient and reliable fusion. The increased contact area between adjoining multicellular bodies also promotes efficient and reliable fusion. Methods of producing multicellular bodies having characteristics that facilitate assembly of the three-dimensional constructs are also provided.

The present invention 10 discloses a domed covering element sized to cover and protect the entire wheel rim 14 while leaving the tire 16 fully exposed. A handle member 12 is fixedly attached to a central portion of the convex side of the covering element 10 to allow the user 18 to easily and rapidly put the present invention 10 into position and maintain it there with the use of just one hand so the other is free to spray or brush on the tire dressing 20. The domed shape of the covering element 10 keeps the user's hand 18 away from the dressing solution 20 during the application thereof as well as protecting the wheel rim 14 from getting scuffed from contact with the surface of the covering element. The present invention may include a resilient, compressible gasket 24 which encompasses the periphery of the covering element 10 to form an impermeable seal when a slight pressure is applied thereto. The gasket 24 assures that no solution 20 will pass therethrough and contact the wheel rim 14 even when heavily applied.

The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the organ growth sections of the organ layer via the micro inlets and outlets of the organ growth sections; the antra layer is configured to comprise a multiplicity of cavities and tubes arranged to be in fluid communication with selected organ equivalents or organ growth sections in order to allow for exchange of fluids between cavities and organ growth sections; and the actuator layer is configured to comprise a multiplicity of actuators arranged and configured to regulate a pressure force applied on a selected organ equivalent, the self-contained circulation system and / or part thereof.