The invention relates to the field of transformers, in particular to a high-speed railway vehicle-mounted isolation transformer, comprising a transformer housing, a noise reduction mechanism, a vibration reduction mechanism, an insulation pad, a bottom plate, an adjusting mechanism, an auxiliary conveying mechanism, a first heat dissipation mechanism and a second heat dissipation mechanism, wherein, the bottom of the transformer housing is fixedly connected with two limit frames with a V-shaped structure. For moving, a surface plate is suspend by rotating a turntable, and slide plates are extracted to move the transformer housing; for installation, the sliding plates are slid into the inside of the limit frames, and the rotary table is rotated counterclockwise to realize the upward movement of the pushing board in the fixing sleeve, so as to realize the suspension of the universal wheels, and the fixation between the ground plate and the ground; the support and fixation of the whole structure are realized, and the installation, the handling and the inspection and repair are convenient.