30 results about "Xylaria nigripes" patented technology

The invention discloses application of a xylaria nigripe extract in a skin whitening and moisturizing cosmetic. The inventor finds that the xylaria nigripe extract has the better moisturizing effect, can effectively inhibit the activity of in-vitro tyrosinase and has the effect of skin whitening for the first time. According to the application of the xylaria nigripe extract in the skin whitening and moisturizing cosmetic, the application field of xylaria nigripe is broadened, and the economic using value of xylaria nigripe is improved.

The invention discloses a Xylaria nigripes fermented liquid powder, the preparation and application thereof. The Xylaria nigripes fermented liquid powder is obtained by carrying out the liquid fermentation of Xylaria nigripes, obtaining mycelium and fermented liquid through solid-liquid separation, filtering monosaccharide, amino acid and other small-molecular organic compounds and inorganic salts of the fermented liquid by an ultrafiltration membrane, then drying and grinding. The powder is characterized in that the powder excludes mycelium, eliminates a plurality of inorganic salts, monosaccharide and amino acid of the fermented liquid and preserves the main active component of the fermented liquid such as Xylaria nigripes polysaccharide. The Xylaria nigripes fermented liquid powder can be used for preparing medicine, health care product and food for regulating immunity, improving sleep, resisting anxiety and depression, curing migraine, relieving cough, resisting inflammation and curing phthisis, HBV hepatitis, prostatitis, tumor, female dysmenorrheal and diabetes.

The invention provides a traditional Chinese medicine composition for treating depression. The traditional Chinese medicine composition is prepared from chinese trichilia, buthus martensi kirsch, cistanche, radix paeoniae alba, fossil fragments, nacre mother of pearl, concha ostreae, xylaria nigripes, polygala tenuifolia, rhizoma anemarrhenae, curcuma aromatic, liquorice, polyrhachis dives and eucommia ulmoides. The traditional Chinese medicine composition is clinically applied to treatment of depression.

The invention relates to an antioxidative and whitening composition and a skin care product containing the composition, and belongs to the technical field of cosmetics. The antioxidative and whiteningcomposition is prepared from the following components in parts by weight: 20 to 40 parts of narcissus tazetta bulb extract, 15 to 25 parts of bellis perennis linn extract, 10 to 20 parts of xylaria nigripes extract and 20 to 30 parts of chaenomeles speciosa extract. The composition disclosed by the invention has the advantages that the narcissus tazetta bulb extract, the narcissus tazetta bulb extract, the xylaria nigripes extract and the chaenomeles speciosa extract are organically combined, so that the composition has excellent antioxidative and whitening effects.

The invention discloses application of a xylaria nigripe extract in a skin whitening and moisturizing cosmetic. The inventor finds that the xylaria nigripe extract has the better moisturizing effect, can effectively inhibit the activity of in-vitro tyrosinase and has the effect of skin whitening for the first time. According to the application of the xylaria nigripe extract in the skin whitening and moisturizing cosmetic, the application field of xylaria nigripe is broadened, and the economic using value of xylaria nigripe is improved.

The invention discloses a dendrobium candidum health-care beverage and a making method thereof. The health-care beverage comprises the following components of dendrobium candidum, red jujubes, American ginseng, stevia rebaudiana, xylaria nigripes sclerotia, large-leaved chrysosplenium, honeysuckle flowers, licorice roots, platycodon roots, white granulated sugar, a food nutrient supplement, arabicgum, water and the like. The making method comprises the following steps of firstly thoroughly cleaning the dendrobium candidum, performing air-drying, performing crushing, and performing centrifuging so as to obtain dendrobium candidum extract; taking the red jujubes, performing thorough cleaning, performing air-drying, performing cutting to obtain slices, performing decoction, performing cooling, and performing filtration so as to obtain a red jujube extract; taking the American ginseng, the stevia rebaudiana, the xylaria nigripes sclerotia, the large-leaved chrysosplenium, the honeysuckleflowers, the licorice roots and the platycodon roots, performing thorough cleaning, performing air-drying, performing mixing, performing decoction, and performing filtration so as to obtain a Chineseherbal medicine extract; and mixing the dendrobium candidum extract with the red jujube extract and the Chinese herbal medicine extract, adding the white granulated sugar, the food nutrient supplementand the arabic gum, performing homogenizing treatment, performing canning, and performing sterilization so as to obtain the product namely the dendrobium candidum health-care beverage. The beverage disclosed by the invention does not contain pigment additives, and is rich in nutrition, good in health-care effects, simple in technology and suitable for large-scale industrial production.

The invention discloses scented tea capable of clearing away heart fire and moistening lung and a production method of the scented tea. The scented tea is prepared from the following raw materials in parts by weight: 20 to 30 parts of globeflower, 15 to 25 parts of lily flower, 10 to 15 parts of oolong tea, 6 to 9 parts of rice sprout, 5 to 8 parts of tremella, 4 to 6 parts of indian lettuce, 6 to 8 parts of gingko nut, 4 to 6 parts of xylaria nigripes, 5 to 7 parts of bulbus fritilariae, 4 to 6 parts of radix asparagi, 5 to 7 parts of radix platycodi, 3 to 5 parts of wrinkled gianthyssop herb, 4 to 6 parts of acacia caesia leaf, 2 to 4 parts of mango leaf, 5 to 7 parts of myrtle, 3 to 5 parts of daisy flower, 4 to 6 parts of shaddock peel, 6 to 8 parts of juicy peach, 4 to 6 parts of semen armeniacae amarae, 5 to 7 parts of fructus mume, 10 to 15 parts of nutritional fruit and vegetable powder, 4 to 6 parts of loquat honey and 2 to 4 parts of honey. The scented tea disclosed by the invention has a wide raw material source and is natural and green; the scented tea has good color and luster, rich but not thick aroma and rich fragrance and has the effects of gladdening the heart and refreshing the mind; meanwhile, a plurality of health-care medicinal materials both used as medicine and food are added, so that the scented tea also has the effects of clearing away heart fire and moistening lung, astringing lung and astringe intestine to stop diarrhea, regulating qi-flowing for strengthening spleen, drying dampness and resolving phlegm and the like, and is suitable for different crowds to drink for a long period.

The invention belongs to the field of medicine, relates to a pyrrole and morpholine spirocyclic alkaloid compound and application thereof to preparing anti-oxidative stress medicine for treating cardiovascular diseases and further relates to an extraction and preparation method of the compound. The compound can be obtained by being extracted and separated from traditional Chinese medicine xylaria nigripes powder or obtained through chemical synthesis. Test results show that the compound has a protective function on cell injuries generated by oxidative stress and can be used for preparing the medicine for treating cardiovascular diseases. The compound can further be used for preparing antioxidant medicine and preparations including injections, oral medicine, external medicine and other preparation forms. Please see the molecular formula in the description, wherein configuration of the position 9 and the position 11 is R or S.

The invention discloses a traditional Chinese medicinal composition for enhancing immunity of livestock and poultry, wherein the traditional Chinese medicinal composition is prepared from the following medicinal raw materials in percentage by mass: 3.48-8.70% of xylaria nigripes, 8.70-26.09% of radix astragali, 8.70-17.40% of humifuse euphorbia herb, 5.22-26.09% of gomphostemma roots, 4.35-13.04% of herba gerberae piloselloidis, 8.70-13.91% of Chinese clinopodium herb, 1.74-3.48% of loquat roots, 8.70-13.91% of semen raphani, 2.61-7.83% of Chinese chive seeds and 4.35-13.04% of herb of maidenhair, totaling 100%; and the components are mixed in accordance with proportions, so that powder or other preparations are prepared. On the basis of the compatibility of the various traditional Chinese medicines which are mutually cooperated and supplement each other, the traditional Chinese medicinal composition disclosed by the invention can take combined actions on tonifying qi, securing exterior, raising yang, clearing away heat and toxic materials and the like, and the traditional Chinese medicinal composition can enhance the immunity of the livestock and poultry, prevent the occurrence of common diseases in the livestock and poultry and promote the growth of the livestock and poultry; the traditional Chinese medicinal composition disclosed by the invention is significant in disease-preventing effect, mild in action and free from toxic and side effects; livestock and poultry products are free from drug residues; and the traditional Chinese medicinal additive (the traditional Chinese medicinal composition), as an ideal animal health care product, is simple in production process, convenient to use, easily available in raw materials, low in cost, green and environment-friendly.

The invention discloses a method for simultaneously obtaining selenium-enriched solid fermentation mycelia and high-yield selenium-enriched xylariasp sporocarp. The method comprises the steps of: S1, preparing a liquid culture medium rich in inorganic selenium, sterilizing and then inoculating aspergillus niger spores to be subjected to liquid culture, and thus obtaining liquid strains of aspergillus niger; S2, preparing a solid culture medium, inoculating liquid culture medium of aspergillus niger obtained in the step S1 after sterilizing, and performing solid-state fermentation to the aspergillus niger; S3, preparing a liquid culture medium, inoculating xylaria nigripes seeds, performing liquid culture, and thus obtaining liquid strains of xylaria nigripes; S4, after sterilizing the solid yeast of aspergillus niger obtained in the step S2, inoculating the liquid strains of xylaria nigripes obtained in the step S3 and then culturing; S5, harvesting xylariasp sporocarp grown in the step S4, and thus obtaining the xylariasp sporocarp rich in inorganic selenium; S6, washing residual solid culture medium after harvest, drying after removing the unconverted inorganic selenium, and thus obtaining selenium-enriched xylariasp which has been subjected to solid-state fermentation. According to the method, while the high-yield selenium-enriched sporocarp is obtained, the selenium-enriched solid fermentation mycelia are also obtained.

The invention discloses a traditional Chinese medicine composition for enhancing poultry immunity and promoting poultry growth. The composition is prepared from, by mass, 3.48-8.70% of xylaria nigripes, 8.70-26.09% of radix astragali, 8.70-17.40% of humifuse euphorbia herb, 5.22-26.09% of wooden spike flowers, 4.35-13.04% of herba gerberae piloselloidis, 8.70-13.91% of calamint, 1.74-3.48% of fructus citri, 8.70-13.91% of tuber fleeceflower stems, 2.61-7.83% of semen raphani and 4.35-13.04% of cortex dictamni, wherein the sum of the mass percentages of all the components is 100%. The components are prepared into powder or other preparations according to ratio. The composition can improve poultry immunity, prevent common poultry diseases and promote poultry growth and is free of toxic and side effects, free of medicine residues; the traditional Chinese medicine additive is simple in production process and convenient to use and is an ideal animal health product.

The invention relates to a coarse cereal shish kebab and a preparation method thereof. The coarse cereal shish kebab is characterized by being prepared by the following raw materials in parts by weight: 400-440 parts of mutton, 2-3 parts of xylaria nigripes, 1-1.5 parts of radix peucedani, 2-2.2 parts of myrrh, 0.8-1 part of melon flower, 1.8-2.2 parts of banyan leaf, 1.2-1.4 parts of spiny jujube flower, 1.5-1.6 part of wild lettuce, 0.9-1 part of allium caelureum, 3-4 parts of sesame paste, 7-9 parts of millet, 9-10 parts of black rice, 8-9 parts of ormosia, 4-5 parts of prosomillet, 2-3 parts of wheat gluten, 15-20 parts of fishbone, 10-12 parts of potato, 4-5 parts of milk tea, 3-3.5 parts of white spirit and 10-11 parts of nutritive additive. The coarse cereal shish kebab maintains the nutrition of the mutton and effectively integrates flavors of the millet, the black rice, the fishbone and the like, the flavor of the shish kebab can be significantly improved, the nutrition of the shish kebab is enriched, the taste penetrates into the mutton through curing and frying, the mutton is tender and elastic, and the coarse cereal shish kebab has effects of calming nerves, reducing blood pressure, expelling wind, clearing heat, improving eyesight, detoxifying, activating yang and invigorating a stomach.

The invention relates to a whitening and moisturizing composition and a skin care product with the same, and belongs to the technical field of cosmetics. The whitening and moisturizing composition comprises, by weight, 20-50 parts of narcissus tazetta bulb extracts, 15-25 parts of nymphaea hybrid extracts, 20-40 parts of xylaria nigripes extracts and 15-25 parts of cactus extracts. The narcissus tazetta bulb extracts, the nymphaea hybrid extracts, the xylaria nigripes extracts and the cactus extracts are organically combined together, so that the whitening and moisturizing composition has excellent whitening and moisturizing effects.

The invention discloses a traditional Chinese medicine additive for enhancing the livestock immunity and application thereof. The traditional Chinese medicine additive is prepared from the following active pharmaceutical ingredients in percentage by mass: 3.48 to 8.70 percent of sclerotium of xylaria nigripes, 8.70 to 26.09 percent of radix astragali seu hedysari, 8.70 to 17.40 percent of humifuse euphorbia herb, 5.22 to 26.09 percent of roots of smalltooth gomphostemma, 4.35 to 13.04 percent of pilose gerbera herb, 8.70 to 13.91 percent of whole grass of calamint, 1.74 to 3.48 percent of whole grass of artemisia annua, 8.70 to 13.91 percent of whole plant of rubus sieboldi blume, 2.61 to 7.83 percent of roots and stems of mahonia and 4.35 to 13.04 percent of yard grass, and the sum of all of the ingredients is 100 percent. The ingredients are proportionally made into powder or other preparations. Various kinds of traditional Chinese medicines are matched to be used, achieve the mutual cooperation effects, supplement with each other to achieve the functions of tonifying qi, strengthening superficial body resistance, raising yang, clearing away heat and toxic materials and the like through combined action. The livestock immunity can be improved; the occurrence of common livestock diseases is prevented; the livestock growth is promoted. The traditional Chinese medicine additive has the advantages that the disease prevention effect is obvious; the effect is mild; no toxic and side effects exist; no medicine residue exists in a livestock product; the production process is simple; the use is convenient; raw materials can be easily obtained; the price is low; green and environment-friendly effects are achieved; the traditional Chinese medicine additive belongs to an ideal animal health care product.

The invention belongs to the technical field of cosmetics. The invention in particular relates to essence capable of improving acne marks and scars and a preparation method thereof. The essence is prepared from the following components, by mass: 10 to 30 percent of composition capable of improving acne marks and scars, 1 to 3 percent of butanediol, 1 to 3 percent of 1, 2-pentanediol, 0.01 to 0.06percent of sodium benzoate, 0.01 to 0.03 percent of sorbic acid and the balance of deionized water. The preparation method of the composition capable of improving acne marks and scars comprises the following steps: taking a yeast culture medium containing a geranium wilfordii extract as a fermentation substrate, inoculating saccharomycetes, and performing fermenting to obtain a primary fermentation active matter; and mixing the obtained primary fermentation active matter with a xylaria nigripes culture medium to serve as a secondary fermentation substrate, and inoculating xylaria nigripes forfermentation to obtain the essence. The essence provided by the invention can effectively inhibit excessive proliferation of fibroblasts and prevent excessive synthesis of collagen, and has an excellent effect of repairing acne marks and scars.

The invention discloses a Xylaria nigripes fermented liquid powder, the preparation and application thereof. The Xylaria nigripes fermented liquid powder is obtained by carrying out the liquid fermentation of Xylaria nigripes, obtaining mycelium and fermented liquid through solid-liquid separation, filtering monosaccharide, amino acid and other small-molecular organic compounds and inorganic salts of the fermented liquid by an ultrafiltration membrane, then drying and grinding. The powder is characterized in that the powder excludes mycelium, eliminates a plurality of inorganic salts, monosaccharide and amino acid of the fermented liquid and preserves the main active component of the fermented liquid such as Xylaria nigripes polysaccharide. The Xylaria nigripes fermented liquid powder canbe used for preparing medicine, health care product and food for regulating immunity, improving sleep, resisting anxiety and depression, curing migraine, relieving cough, resisting inflammation and curing phthisis, HBV hepatitis, prostatitis, tumor, female dysmenorrheal and diabetes.

The present invention discloses fruit powder nerve-calming jasminum sambac scented rice, which is prepared from the following raw materials by weight: 60-70 parts of rice powder, 8-10 parts of banana powder, 10-14 parts of apple powder, 10-13 parts of strawberry powder, 25-28 parts of purified water, 2-3 parts of lotus leaf powder, 4-6 parts of tofu, 8-9 parts of purple sweet potato, 0.9-1.2 parts of sclerotium of xylaria nigripes, 1.4-2 parts of herba balanophorae involucratae, 1.3-2.1 parts of jasminum sambac, and proper amounts of honey, sucrose ester, Lactobacillus plantarum and Pediococcus pentosaceus. According to the present invention, the raw material rice powder is subjected to the nutrition fermentation treatment, such that the heavy metal cadmium content in the rice can be effectively reduced, the taste of the original rice powder is improved, and the nutrition value of the regeneration rice is increased; and the prepared health rich has characteristics of complete nutrition, good taste and good quality, and the edible herbs such as the sclerotium of xylaria nigripes, the herba balanophorae involucratae, the jasminum sambac and the like are added so as to provide health functions of qi regulating, middle warmer regulating, nerve calming, stagnation expelling, kidney benefiting, and yin nourishing.

The invention discloses a traditional Chinese medicine composition for reducing blood pressure. The traditional Chinese medicine composition is prepared from, by weight, 6-10 parts of buckwheat leaves, 8-12 parts of broad bean flowers, 6-9 parts of dried lotus leaves, 5-8 parts of sanchi flowers, 7-10 parts of water chestnuts, 4-6 parts of golden cypress, 5-7 parts of plumbagol, 4-6 parts of xylaria nigripes, 3-5 parts of radix polygonati officinalis, 5-7 parts of eucommia ulmoides, 6-8 parts of Chinese hawthorn leaves, 5-7 parts of plantain peels, 4-6 parts of rhizoma gastrodiae, 3-5 parts of yellow loosestrife, 4-6 parts of honeysuckle stems, 2-4 parts of crotalaria-assamica roots, 3-5 parts of fermented smoked plums, 1-3 parts of sunflower seed oil, 3-5 parts of shaddock peels, 4-6 parts of salicornia bigelovii, 0.5-1 part of calendula, 1-2 parts of rhizoma zingiberis and 1-3 parts of honey. The traditional Chinese medicine composition is reasonable in formula, wide in medicine resource and low in cost, and has the effects of cooling blood, reducing blood pressure, clearing away heat, calming the liver, nourishing yin to moisten dryness, promoting urine, relaxing the bowels, soothing the nerves and stopping pain, symptoms such as dizziness, headaches, giddiness, tinnitus, amnesia, palpitation, shortness of breath, insomnia and inattention caused by high blood pressure can be rapidly eliminated, the treatment course is short, effect taking is quick, pressure reduction is stable, and the traditional Chinese medicine composition is suitable for vast high-blood-pressure patients.

The invention relates to xylaria and a method of rejuvenation, slant cultivation and mutation and degradation prevention therefor, discloses Xylaria nigripes bacterial and a method of rejuvenation, slant cultivation and mutation and degradation prevention therefor, Xylaria nigripes bacterial, CGMCC NO.1038. The invention overcomes the problem of difficult in rejuvenation, slant cultivation and mutation and degradation prevention in the prior Xylaria nigripes bacterial. Moreover through the slant cultivation of the bacterial, the produced Xylaria nigripes bacterial mycelium can be made into a specific biological product and be applicable to foods and drugs for human.

The invention relates to the technical field of xylaria nigripes culture, and discloses a method for culturing xylaria nigripes by using a wild termitarium. The method comprises the following steps: S1, selecting a storage room, and placing a plurality of containers in the storage room; S2, digging out native ant nests which are ant nests of odontoterms formosanus in the field, and placing the native ant nests into the containers; S3, putting the odontoterms formosanus into the native ant nests, and artificially feeding the odontoterms formosanus; S4, sprinkling water into the containers to maintain the humidity of the native ant nests; S5, covering the containers with thin films, sealing the containers, and adjusting the temperature and humidity in the storage room; and S6, after culturing for 15 days, observing the growth conditions of xylaria nigripes in the containers. The method is simple, the xylaria nigripes can be cultivated through the native ant nests, the cultivation cost of the xylaria nigripes is reduced, the native ant nests are utilized, and the purpose of protecting the environment is achieved.

The invention provides a medicine for treating nephropathy. The medicine for treating the nephropathy comprises the following effective raw components in parts by weight: 20-25 parts of Xylaria nigripes, 20-25 parts of Inonotus obliquus, 15-30 parts of Ganoderma applanatum Pat, 3-10 parts of climbing entada, 10-25 parts of frog orchid tuber, 1-3 parts of chamois horn, 6-12 parts of cuttlebone, 9-24 parts of turtle shell, 10-15 parts of concha mauritiae, 0.15-0.35 part of bezoar and 0.1-0.3 part of pearl powder. The medicine provided by the invention is obvious effect of treating the nephropathy and is higher in curative ratio.

The invention belongs to the field of medicine and pharmacology, and particularly discloses novel application of xylaria nigripes powder. The xylaria nigripes powder is applied to preparation of the medicine for treating children hyperactivity, and the medicine is excellent in treatment effect, high in safety and small in toxic and side effect.

The invention discloses a traditional Chinese medicine composition for treating yin-deficiency and fire-hyperactivity type depression. The traditional Chinese medicine composition is prepared from the following components: xylaria nigripes, abelmoschus sagittifolius, juniperus indica, acanthopanax brachypus, pogonatum inflexum, fruit or seed of siberian elm, alpina subsp imaicola, all-grass of Arabian themeda, root of brownsheath lilyturf, all-grass of diverseflower swertia, bunge auriculate root and liquorice root. The traditional Chinese medicine composition disclosed by the invention can be used for treating yin-deficiency and fire-hyperactivity type depression clinically.

The invention relates to the technical field of tea capable of invigorating the brain, in particular to student tea capable of nourishing the brain and benefitting intelligence. The student tea comprises the following raw materials in parts by weight: spina date seeds, heterophylly falsestarwort roots, lily bulbs, radix astragali, Chinese cinnamon, dried orange peel, haws, crystal sugar and xylaria nigripes which are mixed in a corresponding proportion, so that the prepared student tea has good capacity for nourishing the brain, benefitting intelligence, soothing the nerves, improving memory and improving immunity of bodies.

The invention discloses a method for simultaneously obtaining selenium-enriched solid fermentation mycelia and high-yield selenium-enriched xylariasp sporocarp. The method comprises the steps of: S1, preparing a liquid culture medium rich in inorganic selenium, sterilizing and then inoculating aspergillus niger spores to be subjected to liquid culture, and thus obtaining liquid strains of aspergillus niger; S2, preparing a solid culture medium, inoculating liquid culture medium of aspergillus niger obtained in the step S1 after sterilizing, and performing solid-state fermentation to the aspergillus niger; S3, preparing a liquid culture medium, inoculating xylaria nigripes seeds, performing liquid culture, and thus obtaining liquid strains of xylaria nigripes; S4, after sterilizing the solid yeast of aspergillus niger obtained in the step S2, inoculating the liquid strains of xylaria nigripes obtained in the step S3 and then culturing; S5, harvesting xylariasp sporocarp grown in the step S4, and thus obtaining the xylariasp sporocarp rich in inorganic selenium; S6, washing residual solid culture medium after harvest, drying after removing the unconverted inorganic selenium, and thus obtaining selenium-enriched xylariasp which has been subjected to solid-state fermentation. According to the method, while the high-yield selenium-enriched sporocarp is obtained, the selenium-enriched solid fermentation mycelia are also obtained.

The invention belongs to the technical field of cosmetics, and particularly relates to eye repair essence and a preparation method thereof. The eye repair essence comprises the following components inpercentage by mass of 1-4% of a hydrating agent, 0.1-0.2% of a thickening agent, 1-6% of soothing oil, 0.5-2% of an emulsifying agent, 1-12% of a xylaria nigripes fermentation product extract, 0.1-0.2% of a preservative, 0.01-0.03% of a chelating agent, 0.01-0.02% of essence and the balance deionized water. The xylaria nigripes fermentation product extract prepared by a special technology is added to the essence, so that eye melanin can be effectively eliminated, and the essence has the effects of promoting eye microcirculation, protecting and reinforcing eye capillary, smoothing fine lines and moistening, is nonirritant to skin, and can be used as a product for dispelling pigment dark eye circles and vascular dark eye circles.

The invention belongs to the technical field of cosmetics, and particularly relates to a composition capable of improving acne marks and scars and a preparation method thereof. The preparation methodof the composition comprises the following steps: taking a yeast culture medium containing a geranium robertianum extract as a fermentation substrate, inoculating saccharomycetes, and carrying out fermenting to obtain a primary fermentation active matter; and mixing the obtained primary fermentation active matter with a xylaria nigripes culture medium to serve as a secondary fermentation substrate, and inoculating xylaria nigripes for fermentation to obtain the composition. According to the preparation method, saccharomycetes and xylaria nigripes are sequentially used for fermenting the geranium robertianum extract; the test finds that the obtained fermentation active matter shows new performance and can effectively inhibit excessive proliferation of fibroblasts, prevent excessive synthesis of collagen and achieve the effect of repairing acne marks and scars; and tests prove that after 28 days of continuous use, the facial brightness is increased by over 28% compared with that before use; after continuous use for 56 days, 90% of acne marks on the face of a subject are eliminated; and the method has more remarkable advantages compared with single-strain fermentation.

The invention relates to the technical field of medical microorganisms and medical compounds, and particularly discloses a compound extracted from a xylaria nigripes rice fermentation product, the compound is named as xylaric acid, the system is named as ((8R, 12R)-9-ethoxy-9-carbonyl-7-phenylpropane-8-substituted)-D-leucine, the preparation method of the compound is disclosed, and the application of the compound in pharmacy is also disclosed. The compound disclosed by the invention has relatively remarkable neuroprotective activity, can be applied to preparation of novel neuroprotective medicines, and is used for treating depression including but not limited to anxiety disorder and improving cognitive impairment and motion retardation of patients with neurodegenerative diseases. The result of the embodiment shows that the xylaric acid provided by the invention can obviously improve the survival rate of the damaged nerve cell PC12 of the model, and has a better inhibition effect on the apoptosis of the nerve cell PC12.