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Composition capable of improving acne marks and scars and preparation method thereof

A composition and scar technology, applied in the direction of drug combination, skin care preparations, medical preparations containing active ingredients, etc., can solve the problems of no acne marks and scars, achieve low irritation, repair acne marks and scars , Repair acne marks and scars

Active Publication Date: 2020-11-13
广州市万千粉丝化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that the fermented extract of C. nigritiformis has anti-free radical, anti-oxidation, anti-aging and whitening effects, but it has not been used to improve acne marks and scars

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, preparation of slender geranium alcohol extract

[0031] Take slender geranium hay, wash, dry, and pulverize into fine powder; add 55% ethanol solution according to the ratio of 1g:15ml of solid to liquid, reflux extraction twice, combine the extracts, remove ethanol under reduced pressure, and concentrate to obtain .

Embodiment 2

[0032] Example 2. Preparation of a composition that can improve acne marks and scars

[0033] S1. According to the added volume of the slender geranium extract being 22% of the volume of the yeast medium, mix the slender geranium extract with the yeast medium, and sterilize at 121° C. to obtain a primary fermentation substrate;

[0034] S2. Inoculate the above-mentioned primary fermentation substrate with Candida CGMCC2.1763 cultured on a shaking table in advance, so that the yeast concentration in the substrate is 8×10 6 cfu / ml, for fermentation, after the fermentation, take the fermentation liquid, sterilize, and let it stand for cooling to obtain the primary fermentation active substance. The fermentation parameters are: pH value is 4.3-5.8; stirring speed is 100-200rpm; 4VVM; fermentation temperature is 28°C; fermentation time is 4 days;

[0035] S3. According to the added volume of the primary fermentation active substance being 15% of the volume of the C. nigriscens cul...

Embodiment 3

[0037] Example 3. Preparation of a composition that can improve acne marks and scars

[0038] S1. According to the added volume of the slender geranium extract being 16% of the volume of the yeast medium, mix the slender geranium extract with the yeast medium, and sterilize at 121° C. to obtain a primary fermentation substrate;

[0039] S2. Inoculate the above-mentioned primary fermentation substrate with Candida CGMCC2.1763 cultured on a shaking table in advance, so that the yeast concentration in the substrate is 8×10 6 cfu / ml, for fermentation, after the fermentation, take the fermentation liquid, sterilize, and let it stand for cooling to obtain the primary fermentation active substance. The fermentation parameters are: pH value is 4.3-5.8; stirring speed is 100-200rpm; 4VVM; fermentation temperature is 30°C; fermentation time is 3 days;

[0040] S3. According to the added volume of the primary fermentation active substance being 18% of the volume of the C. nigriscens cultu...

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Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a composition capable of improving acne marks and scars and a preparation method thereof. The preparation methodof the composition comprises the following steps: taking a yeast culture medium containing a geranium robertianum extract as a fermentation substrate, inoculating saccharomycetes, and carrying out fermenting to obtain a primary fermentation active matter; and mixing the obtained primary fermentation active matter with a xylaria nigripes culture medium to serve as a secondary fermentation substrate, and inoculating xylaria nigripes for fermentation to obtain the composition. According to the preparation method, saccharomycetes and xylaria nigripes are sequentially used for fermenting the geranium robertianum extract; the test finds that the obtained fermentation active matter shows new performance and can effectively inhibit excessive proliferation of fibroblasts, prevent excessive synthesis of collagen and achieve the effect of repairing acne marks and scars; and tests prove that after 28 days of continuous use, the facial brightness is increased by over 28% compared with that before use; after continuous use for 56 days, 90% of acne marks on the face of a subject are eliminated; and the method has more remarkable advantages compared with single-strain fermentation.

Description

technical field [0001] The invention belongs to the technical field of cosmetics. More specifically, it relates to a composition capable of improving acne marks and scars and a preparation method thereof. Background technique [0002] Acne marks are the red spots or flaky red, brown, gray and other uneven skin tone left on the face after the acne is eliminated. Usually, the acne is not properly treated, which leads to skin inflammation and destroys the formation of skin tissue. The scar refers to the damage of physical, biological, chemical and other factors acting on the soft tissue of the human skin, resulting in serious damage to the soft tissue of the skin, which cannot be completely repaired normally by itself, and is transformed into a local symptom of fibrous tissue replacement repair, which not only affects the appearance of the face, but also Affect local skin function. [0003] The slender geranium extract can directly act on the deep skin to repair, revitalize t...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/9728A61Q19/00A61P17/10A61P17/02
CPCA61K2800/5922A61K2800/85A61Q19/00A61K8/9728A61K8/9789A61P17/02A61P17/10
Inventor 陈绍胜
Owner 广州市万千粉丝化妆品有限公司
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