261 results about "Peripheral Blood Vessel" patented technology

Method and apparatus for monitoring the sleep state condition of an individual by using an external probe applied to a peripheral body location, such as the individual's finger or toe, for detecting changes in the peripheral vascular bed volume of the individual. A predetermined pressure field is applied to the distal end of the peripheral body location, including its distal-most extremity, to prevent the occurrence of venous pooling within and distal to the peripheral body location. The probe produces an output corresponding to changes in the peripheral arterial bed volume at the peripheral body location, which output provides an indication of the sleep state condition of the individual. Such information is useful in diagnosing and / or in treating, a number of sleep disorders as well as other conditions, such as impotence, diabetes, and various disorders in children.

A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.

The present invention relates to a method and apparatus for monitoring haemodynamic function in animals and humans during anaesthesia and surgery. During anaesthesia and surgery the subject's haemodynamic, respiratory, neuromuscular and neurological functions are monitored as indicators of the condition of the health of the subject. Commonly, variations in blood pressure are used to imply corresponding variations in cardiac output, i.e. good blood pressure equals good cardiac output. The present invention utilizes a device to monitor changes of blood flow in peripheral blood vessels of the subject as an indicator of cardiac output. This is believed to provide a much more accurate indicator.

A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.

Compositions and methods of using cells derived from postpartum tissue such as the umbilical cord and placenta, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed.

A blood pressure monitoring system includes a blood pressure measurement device for measuring blood pressure using a cuff, a memory for storing an externally inputted pulse wave propagation time fluctuation threshold, a time interval detection reference point detection section for detecting a time interval detection reference point in a pulse wave on the side of aortae of a living organism, a pulse wave detection section for detecting a pulse wave on the side of peripheral blood vessels appearing with a time lag with respect to the pulse wave on the side of aortae, a pulse wave propagation time measurement section for measuring a pulse wave propagation time based on respective detected outputs from the time interval detection reference point detection section and the pulse wave detection section, an operation device for calculating a pulse wave propagation fluctuation from two measured pulse wave propagation times, a judgment device for judging whether or not the calculated pulse wave propagation time fluctuation exceeds the pulse wave propagation time fluctuation threshold read from the memory, and a control device for controlling the blood pressure measurement device based on an output of the judgment device so that the blood pressure of a subject is measured using the cuff.

Invention relates to catheter placement devices for peripheral blood vessel catheterization with protected needle tip and shortened length in a transport position (see FIG. 31). In the transport position (FIG. 9), the needle and catheter units (1 and 5) are held inside the handle (8). User transposes the needle and catheter units into a duty ready position (FIG. 6), wherein the needle unit is engaged with the handle distal end and a catheter hub (7) protrudes distally out of the handle. After catheter insertion into patient vein, user disconnects the needle unit and handle allowing the needle unit retraction by a resilient member (11) into the protection position. The trigger and transposing means (22) location enables the apparatus single handed control. The fixation means (31) in the protection position eliminates repeated needle unit advance. It can be used rubber or spiral spring resilient members and the catheter hubs with foldable side wings and side port.

A delivery system for rapid placement of heart implants is provided that includes a delivery platform. The delivery system includes a tubular catheter body, a piercing member, and a delivery platform. The tubular catheter body is sufficiently long and flexible to be advanced from a peripheral blood vessel access site to an atrium of the heart. The piercing member is configured to create a transapical channel from an internal apical portion of a ventricle to an outside heart wall. The delivery system includes an elongate tension member and an enlargeable member disposed on a distal portion of the elongate tension member. The enlargeable member is configured to be enlarged in a pericardial space of an intact chest wall to cover an area of the outside heart wall surrounding an opening of the transapical channel. When tensioned, the tension member provides a stable zone for positioning a heart implant within the heart.

The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.

This invention provides devices and methods for insertion of a catheter into a vessel. The devices include coaxial slidably mounted needle, dilator and catheter components. The methods include piercing a vessel with the needle component, dilating the pierced hole with the dilator component, retraction of the needle component, insertion of the catheter and withdrawal of the dilator.

Novel piperzine derivatives substituted on one nitrogen by an aromatic system and on the other nitrogen by (2,5-dioxopyrrolidin)-1-yl) alkanes or (2,6-dioxopiperidin-1-yl) alkanes have been found to exhibit selective alpha 1A adrenergic activity. The compounds are useful for treatment of disease conditions, such as peripheral vascular disease, congestive heart failure, hypertension and especially benign prostatic hypertrophy.

A method and apparatus for ultrafiltration of blood operating by removing blood from a peripheral blood vessel at a rate of less than two percent of total cardiac output of a patient, extracting fluid at a rate of 0.1 liter to 1.0 liters per hour while retaining cells and proteins in the blood, and returning the concentrated blood to a secondary blood vessel is disclosed. Blood is removed and returned using small gage needles. As a pump circulates blood from the patient, a filter removes ultrafiltrate from the blood using duty cycle or pump control, and a transparent container collects the removed fluid.

Techniques for diagnosing peripheral vascular disease using oxygen saturation are provided. Changes in oxygen saturation in tissue during recovery from induced ischemia are measured. The changes are then utilized to diagnose whether a patient has peripheral vascular disease.

The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.

An apparatus, system and method for re-canalization or opening a passage through an occlusion in a blood vessel is disclosed. The apparatus and method, which are appropriate for both cardiovascular as well as peripheral vessels, use hydraulic pressure to drive a vibratable member, and the system includes a control unit to permit the frequency or amplitude of oscillation of the vibratable member to be adjusted to suit the morphology or hardness of the target occlusion. Also disclosed is a method for adjusting the force of vibration.

A dual lumen introducer sheath provides access to at least one renal artery and at least one peripheral blood vessel of a patient. The introducer sheath includes a proximal hub comprising first and second ports, a first lumen, and a second lumen. The first lumen extends from the first port to a first distal aperture and has sufficient length such that when the first port is positioned outside the patient the first distal aperture is positionable in the abdominal aorta at or near origins of the patient's renal arteries. The second lumen extends from the second port to a second distal aperture, has a shorter length than the length of the first lumen, and is configured to allow passage of a catheter device through the second lumen and into or through an iliac artery contralateral to an insertion point of the introducer sheath into the patient.

An extracorporeal blood circuit is disclosed for withdrawing, filtering and returning blood from peripheral blood vessels. The blood passage in the circuit extends through a withdrawal tube connected to a catheter in a peripheral vein, a filter, one or more pressure sensors and return tube also connected to a catheter in a peripheral vein (which may or may not be the same vein as used for the withdrawal tube). The blood passage is air free, and has smooth passage walls which promoted continuous and uniform flow of the blood through the circuit.

A system and method of accessing a heart of a patient is provided. A cardiac access channel is established through an apical wall of the heart to provide direct access through the apical wall to the left ventricle. A vascular access channel is established through the skin to a peripheral blood vessel. A first end of an elongate member is advanced from the outside of the apical wall through the cardiac access channel and into the left ventricle. A second end disposed opposite the first end remains outside the patient. The elongate member is drawn into and through the vascular access channel to externalize the first end of the elongate member while leaving the second end outside the apical wall of the heart.

A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold has a structure that produces a low late lumen loss when implanted within a peripheral vessel and also exhibits a high axial fatigue life. In a preferred embodiment the scaffold forms ring structures interconnected by links, where a ring has 12 crowns and at most two links connecting adjacent rings.

The present invention concerns novel stent apparatuses for use in treating lesions at or near the bifurcation point in bifurcated cardiac, coronary, renal, peripheral vascular, gastrointestinal, pulmonary, urinary and neurovascular vessels and brain vessels. More particularly, the invention concerns a stent apparatus with at least one side opening which may further comprise an extendable stent portion laterally extending from the side opening and at least partly in registry with the wall of the side opening. Devices constructed in accordance with the invention include, singularly or in combination, a main expandable stent comprising at least one substantially circular side opening located between its proximal and distal end openings, which side opening may further comprise an expandable portion extending radially outward from the edges of the side opening; and a branch stent comprising proximal and distal end openings and which may further comprise a contacting portion at its proximal end, and which may optionally be constructed to form either a perpendicular branch or a non-perpendicular branch when inserted through a side opening of the main stent. The stents of the invention are marked with, or at least partially constructed of, a material which is imageable during intraluminal catheterization techniques, most preferably but not limited to ultrasound and x-ray.

The invention provides a preparation technique of a three-layer (inner, middle and outer layers) artificial blood vessel. The inner layer is composed of a smooth compact thin layer prepared by an ink printing method and can inhibit plasma protein and platelet adhesion, prevent acute thrombosis formation and provide axial mechanical support. The middle layer is formed by winding oriented micro fiber prepared by wet spinning or melt spinning, and mainly functions in guiding tissue cells to grow into gaps of the oriented fiber to realize oriented deposition arrangement of extracellular matrix, and the oriented micro fiber can provide radial mechanical support. The outer layer is formed by winding thick polymer fiber and closely bonded with the middle layer and mainly functions in preventing folding when the artificial blood vessel is bent. The artificial blood vessel prepared by the method can remarkably increase patency rate, can utilize microenvironment at an implanting position to realize quasi-natural reshaping and regeneration and has good application prospect in the aspects of coronary artery bypass surgery, hemodialysis and cerebral and peripheral blood vessel replacement.

The present invention provides a portable device and method for enhancing blood flow in a limb and for reducing the risk of peripheral vascular disorders formation by applying periodic squeezing forces on a limb, in particular a lower limb. The device comprises an actuator and two rigid or semi-rigid flaps connected respectively to opposite sides of a housing such as to form an open closure around the limb. The housing contains machinery for actuating periodical change in the position of said flaps between contracted and relaxed positions.

Provided herein are compositions and methods for preventing, ameliorating, and / or reducing tissue ischemia and / or tissue damage due to ischemia, increasing blood vessel diameter, blood flow and tissue perfusion in the presence of vascular disease including peripheral vascular disease, atherosclerotic vascular disease, coronary artery disease, stroke and influencing other conditions, by suppressing CD47 and / or blocking TSP1 and / or CD47 activity or interaction. Influencing the interaction of CD47-TSP1 in blood vessels allows for control of blood vessel diameter and blood flow, and permits modification of blood pressure and cardiac function. Under conditions of decreased blood flow, for instance through injury or atherosclerosis, blocking TSP1-CD47 interaction allows blood vessels to dilate and increases blood flow, tissue perfusion and tissue survival. This in turn reduces or prevents tissue necrosis and death. The therapeutics identified herein allow for precise regulation of blood flow to tissues and organs which need it, while substantially avoiding systemic complications. Methods and compositions described herein can be used to increase tissue survival under conditions of trauma and surgery, as well as conditions of chronic vascular disease. Also disclosed are methods for the treatment of elderly subjects using agents that affect TSP1 and CD47 and thereby affect tissue perfusion. Additionally, provided herein are compositions and methods for influencing blood coagulation, allowing for controlled increased or decreased blood clotting. Additionally, provided herein are compositions and methods for decreasing blood flow, as in the case of cancer through mimicking the effects of TSP1 and CD47 on blood vessel diameter and blood flow.

The invention is directed to methods and systems of hyperspectral and multispectral imaging of medical tissues. In particular, the invention is directed to new devices, tools and processes for the detection and evaluation of diseases and disorders such as, but not limited to diabetes and peripheral vascular disease and cancer, that incorporate hyperspectral or multispectral imaging.

The invention discloses an intravascular stent of a composite structure; the intravascular stent comprises a stent main body, wherein the distal end of the stent is restrained as an adducted form by virtue of a tightening wire, and the tightening wire is degradable magnesium alloy or degradable iron alloy; one or more auxiliary wires are woven on the stent main body; when the stent is applied to blood vessel of brain, the auxiliary wire is pure platinum or alloy thereof, pure gold or alloy thereof, pure tungsten or alloy thereof, or pure tantalum or alloy thereof; and when the stent is applied to peripheral blood vessel, the auxiliary wire is cobalt-chromium alloy or stainless steel or tungsten or tantalum. The stent, when serving as a thrombus removal system for treating cerebral apoplexy, not only can be used for removing thrombus effectively for several times but also can be used for catching small thrombus flowing to distal end so as to prevent distal blood vessels from getting blocked; and the stent can be used for dilating stenosis or blocked brain blood vessel or peripheral blood vessel, so as to take an effect of dredging and reconstructing a blood flow. The stent can be repositioned and released, with high controllability; and the stent can be used for reducing operation difficulty and greatly improving an operation success rate.

An apparatus, system and method for re-canalization or opening a passage through an occlusion in a blood vessel is provided. The apparatus and method, which are appropriate for cardiovascular and peripheral vessels, use a pulling member and a spring member, for example a compression spring, to oscillate a drilling component. The drilling component at the distal end of the catheter tip has combined longitudinal stiffness for penetrating a total or partial occlusion and high axial (lateral) flexibility to improve deliverability and crossability of a catheter through a partially occluded vessel or a tortuous vessel, and may taper distally. The system of the invention includes the apparatus and a control unit to permit adjustment of the frequency or amplitude of oscillation of the drilling component. Also provided is a method for oscillating a drilling component using a pulling member and a spring member and a method of traversing an occlusion.

The invention discloses terahertz activated ceramic particles and a preparing method thereof. The terahertz activated ceramic particles are composed of raw materials of natural minerals, animal and plant materials, auxiliaries and MC activated water, the raw materials are prepared into slurry through the MC activated water, terahertz wave treatment is conducted, and then high-temperature calcination is conducted to obtain the ceramic particles; actual detection shows that the activated ceramic particles can stably emit terahertz waves with the wave length of 4-16 micrometer and the frequency of 0.5-10.0 THz, and the normal emissivity reaches 85% or above. If terahertz activated ceramic particle is adopted to treat water, the PH value of the water is increased to 10-12.5 or above, ORP reaches -250 mV, and 0.5-5.0 mA current is generated; when the activated water with the physical and chemical properties is applied to the human body, expansion which promotes human body peripheral blood vessels is generated, restoration of tissue functions is promoted, blood microcirculation is improved, fatigue matter of lactic acid and the like are removed, and health care functions of metabolism and the like are improved; when the activated water with the physical and chemical properties is applied to the medical field, multiple kinds of bacteria and viruses can be killed; when the activated water with the physical and chemical properties is applied to cars, miraculous effects that oil is saved by 13%-15% and discharge is reduced by 68%-75% can be generated, and the market prospect is huge.

An apparatus, system and method for re-canalization or opening a passage through an occlusion in a blood vessel is provided. The apparatus and method, which are appropriate for both cardiovascular as well as peripheral vessels, use a pulling member and a spring element, for example a compression spring, to oscillate a vibratable member, and the system of the invention includes the apparatus and a control unit to permit the frequency or amplitude of oscillation of the vibratable member to be adjusted. Also provided is a method for oscillating a vibratable member using a pulling member and a spring element. The apparatus and system are useful not only for penetrating a total or partial occlusion, but also to improve deliverability of a catheter through a partially occluded vessel or a tortuous vessel.

The utility of pulse volume measurement is expanded to detection of many conditions which have previously not been detected or have been detected using more complicated techniques. Such conditions include blood loss, septic shock, cardiogenic shock, neonatal sepsis, patent ductus arteriosus, limb ischemia, intra-aortic balloon pump performance, peripheral vascular disease, congestive heart failure, the effectiveness of vasoactive medications, syncope, dehydration, pre-eclampsia, deep vein thrombosis, thermal injuries, vascular instability due to renal dialysis, compromising of circulation to the hand caused by radial artery harvesting, changes in cardiac output, and hypertension. According to the present invention, such diagnoses can be performed by taking one measurement, by taking measurements over time to detect a change or by taking measurements before and after application of a treatment or stimulus.