The invention discloses medicine for treating recurrent oral ulceration, and belongs to the technical field of traditional Chinese medicine. The medicine is prepared from raw materials including radix bupleuri, chrysanthemum, roots of Raeonia lactiflora pall, angelica sinensis, dogwood, Chinese yam, raw radix astragalis, the root bark of the peony tree, polygala tenuifolia, cortex albiziae, vine of multiflower knotweed, lucid ganoderma, semen boitae, spina date seed, cinnabar, dragon bone, rhizoma atractylodis macrocephalae, orange peel, codonopsis pilosula, fructus amomi, agastache rugosus, dioscorea oposetap thunb, membrane of goose gizzard, gorgon fruit, semen nelumbinis, dried radix rehmanniae, lily, radix ophiopogonis, the fruit of Chinese wolfberry, radix scrophulariae, the root of straight ladybell, sculellaria barbata, Chinese lobelia, ternate buttercup root, dandelion, oldenlandia diffusa and viola. The traditional Chinese medicine can effectively treat recurrent oral ulceration, effectively adjust the yin and yang balance of a body, relief liver for smoothing Qi, clear liver fire, thoroughly change the physical unbalance, fundamentally restrain virus breeding in an oral cavity, effectively remove viruses, keep the oral cavity healthy and prevent recurrent oral ulceration from recurring; by means of the medicine, the sleeping quality can be improved, the physical function can be adjusted, qi can be replenished and blood can be nourished, complexion can be improved, and the effects of maintaining beauty and keeping young can be achieved.