38 results about "Optode" patented technology

A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomers have pendent alkyl groups of different length and wherein the functionalized ion-exchanger is grafted into the copolymer through covalent linkages. The ion exchanger comprises a C-derivative of a halogenated closo-dodecacarborane anion having a polymerizable moiety. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.

Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomers have pendent alkyl groups of different length and wherein the functionalized ion-exchanger is grafted into the copolymer through covalent linkages. The ion exchanger comprises a C-derivative of a halogenated closo-dodecacarborane anion having a polymerizable moiety. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.

A gas sensor system and its method of fabrication is disclosed. The sensor system comprises an optrode, light source, and a light detector. In a sensor for hydrogen gas, the optrode is comprised of a porous substrate into which an intimate mixture of reagent and catalyst is incorporated. The mixture reacts with the hydrogen to produce a color / intensity change in relation to the concentration of gas. The optrode further includes a reversing agent, boron, to restore the benchmark conditions of the sensor system in real-time. The method of fabricating the optrode includes the steps of cleaning; etching to achieve the proper porosity; incorporating the reagent, catalyst, and reversing agent using capillary action; and removing excess reagent and catalyst.

The invention relates to a photopole biomolecular sensor, in particular to a graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor. The graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor comprises a fiber core, a fiber cladding and a fiber coating layer, wherein a large-angle tilting fiber bragg grating is arranged at the tail end of the fiber core; a coating layer on the surface of the cladding of the large-angle tilting fiber bragg grating is completely removed; the end surface of the tail end of the large-angle tilting fiber bragg grating is coated with a silver reflective film; a silane layer is arranged on the surface of the cladding of the large-angle tilting fiber bragg grating; a gold nanoshell particle layer is fixed on thesurface of the silane layer; a graphene oxide layer is adsorbed to the surface on which the gold nanoshell particle layer is fixed; and a biomolecular sensitive layer is fixed on the surface of the graphene oxide layer. By adopting the photopole biosensor structure provided by the invention, the operating distances of LSPR excited by a light wave evanescent field and biomolecules can be increased,and the photopole biosensor structure is convenient to integrate and use, has very high robustness and can be applied to the field of biology, medicine, environment monitoring, food safety, life science and the like.

The invention relates to a photoelectrode biomolecular sensor, in particular to a broadband interference type photoelectrode biomolecular sensor and method of a graphene oxide fiber bragg grating. Thesensor comprises an optical fiber core, an optical fiber cladding, an optical fiber coating layer, and a large-angle inclined fiber bragg grating arranged in the middle of the optical fiber core; coating layers of the middle section and the rear section of an optical fiber are completely removed, the tail end surface of the rear section of the optical fiber is plated with a silver reflecting film, the distance between the rear end of the large-angle inclined optical fiber grating and the silver reflecting film at the tail end of the optical fiber ranges from 30 mm to 60 mm, and an optical fiber micro Michelson interference cavity is formed. A silane layer, a nano gold shell particle layer, a graphene oxide layer and a biomolecule sensitive layer are arranged on the cladding surface from the starting end of the large-angle tilted fiber bragg grating to the tail end of the optical fiber. The photoelectrode biomolecular sensor structure can be used to increase the action distance betweenLSPR excited by a light wave evanescent place and biomolecules, is convenient to integrate and apply, has very high robustness, and can be applied to the fields of biomedicine, life science, environmental monitoring and the like.

Ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of said ion, wherein at least a portion of the functionalized ionophore is grafted into the copolymer through covalent linkages. Sensors may comprise ionophores such as hydrophilic crown ethers or functionalized derivative of 3-oxapentandiaminde-type ionophores. This invention further provides sensors for detecting target ions in a sample, comprising plasticizer-free molecularly imprinted polymers, wherein the polymers comprise polymerized units of methacrylate monomers having pendent alkyl groups of different length and a functionalized ionophore of said ion. In particular, a magnesium ion sensor comprising a functionalized derivative of a 3-oxapentandiaminde-type calcium ion-selective ionophore is provided. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.

An in vitro sensor for point-of-care detection of at least one analyte or reaction product includes an inert, impermeable substrate, a sensing system, and a reference system. The substrate includes a first transparent surface oppositely disposed from a second surface and first and second cavities. Each of the first and second cavities defines an opening at the second surface. The sensing system is disposed in at least a portion of the first cavity and includes an analyte-detection optode membrane, an analyte-permeable membrane, and a plurality of non-transparent microbeads associated with at least one of the analyte-detection optode membrane and the analyte-permeable membrane. The analyte-permeable membrane is layered upon the analyte-detection optode membrane and covers the opening of the first cavity. The reference system is disposed in at least a portion of the second cavity.

A water-soluble lithium salt is added as a tracer substance along with a water treatment chemical to water to be treated. The concentration of lithium ions is electrochemically or optically measured using a lithium ion sensitive substance, so as to perform concentration control of the water treatment chemical added to water to be treated. An ion selective electrode, ion selective field effect transistor, or ion optode may be employed to perform the electrochemical or optical measurement using a lithium ion sensitive substance.

The present invention relates to a method for the preparation of a miniaturized optical chemical or biochemical sensor device (e.g. bulk optode, etc. for ion sensing), said device comprising a substrate material having a planar surface portion, said planar surface representing a transducer based on an optical phenomenon such as surface plasmon resonance based on evanescent waves, reflection or transmission; said planar surface portion having arranged thereon an multi-analyte array of (bio)chemical sensor dots located at spatially separated predetermined positions of the planar surface, said sensor dots including (i) a polymer matrix, and (ii) one or more (bio)chemical recognition moieties, the method comprising (a) providing a substrate material having a planar surface portion; (b) providing one or more spotting fluid(s); (c) depositing the one or more spotting fluid(s) onto the planar surface portion of the substrate material by means of a pin-printer deposition mechanism (arrayer) and allowing the spotting fluid(s) to consolidate.

The present invention relates to π-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion.Fluoroionophoric compounds of the general formula I are describedIonophore-π-Linker-Fluorophore  (I)whereinthe Ionophore is an anilino containing crown ether or cryptand with one or more anilino donor moieties as electron donors, forming a stable complex with an alkali metal ionthe π-Linker is an aromatic or heteroaromatic conjugative linking moiety, and the Fluorophore is an electron acceptor moiety.Variation of the ionophoric unit offers a broad spectrum of detectable K+ and Na+-concentrations, ranging from high concentration around 800 mM down to very low concentrations around 3 mM.The fluoroionophores have great potential for application in fluorescent optode system based blood analyzing equipment for methods and kits for the determination of K+ and Na+ concentrations in biological systems, either in vitro or in vivo, using embodiments of the disclosed fluoroionophores.

A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.

A composition comprising a pH indicator, a polymerizable group, and a spacer therebetween. The polymerizable group can be acrylate or methacrylate and the spacer can be an oxyalkayl group, an oxypropyl group, or an oxybenzoyl group. The composition can be polymerized to copolymers to form indicating polymers and optodes.

An improved luminescent optode is disclosed that is capable of conducting a self-test to determine the quality of the optode's measurement of the concentration of a quenching molecule in a fluid, along with a method for conducting the self-test.

Disclosed herein are compositions comprising an oblong optode sensing agent. The oblong optode sensing agent comprises a core and a semipermeable membrane, wherein the core comprises one or more sensors configured to bind to an analyte. In addition, methods of making and detecting the oblong optode sensing agents are disclosed.

Provided is a device for measuring electrolyte ions that is capable of providing a uniform pH environment in the region of an optode, and a method of measuring electrolyte ion concentration using the device.

The invention provides a multichannel wireless heredity photostimulation system and method. The system comprises an upper computer, a photostimulator and an array type stimulating light pole, wherein the photostimulator comprises a plurality of stimulating channels, different stimulating channels electrically communicate with different zones of the array type stimulating light pole, the upper computer is used for setting photostimulation parameters, the photostimulation parameters comprise frequency of pulses, duty ratio, stimulation time and one or more stimulating channels, the upper computer is in wireless connection with the photostimulator, and the photostimulator is used for receiving the photostimulation parameters set by the upper computer and outputting electric pulse signals to zones of the array type stimulating light pole electrically communicating with the stimulating channels in the photostimulation parameters. According to the method and the system, stimulated zones can be independently selected.

The invention discloses a drive-by-wire photostimulator for light adjustment and control of nerves. The drive-by-wire photostimulator comprises an interaction module, a LED light source coupling optical fiber and an implanting type nerve stimulation optrode, wherein the interaction module comprises an operation button, a master controller, a displayer, an LED drive and an LED light source, the operation button is electrically connected with the signal input end of the master controller, the control end of the displayer and the control end of the LED drive are respectively and electrically connected with the signal output end of the master controller, the LED light source is electrically connected with the output end of the LED drive, one end of the LED light source coupling optical fiber is coupled with the LED light source through an optical fiber coupling interface, and the other end of the LED light source coupling optical fiber is connected with the implanting type nerve stimulation optrode. Under the premise of guaranteeing stable properties and low price, large-range adjustment and control on nerve nuclei and micro-load long-time carrier stimulation are realized through LED.

Portable bimodal probe intended to be applied to a biological tissue to be examined, the probe comprising: - an ultrasonic transducer (34, 63) configured to transmit ultrasonic waves into the tissue and to receive ultrasonic waves reflected by the tissue, the transducer extending along a transverse axis; - at least two optodes (32, 60, 62a, 62b) arranged on either side of the transverse axis, such that the transducer extends between the two optodes; - each optode comprising a housing (52, 61), the housing comprising: a light transmitter (31) configured to transmit a light wave to the tissue; and / or an optical detector (32) configured to detect a light wave propagated by the tissue; - the optodes being designed such that at least one light transmitter and at least one optical detector are arranged on either side of the transducer; - at least one optical detector having a detection surface (53, 63a, 63b) formed of a semiconductor material and connected to an electronic card (54).

The present disclosure provides a device for monitoring and visualising electrical activity of biological tissue. The device uses a sensor arrangement comprising a matrix of conductive sensors and a transducing element for transducing electric fields in a variation of an optical property. In use, electric fields generated by the biological tissue are sensed by the sensor arrangement and transduced by the transducing element for optical imaging.

In order to realize real-time monitoring of calcium ion concentration, the invention provides a calcium ion detection photoelectrode based on special optical fiber surface film modification. According to the invention, the required calcium ion concentration sensor is produced by adopting a polymer-based optical fiber and calcium ion photoelectrode end surface modification method.

A method for determining the concentration of an analyte in a sample liquid, in which a) by means of a radiation source (3, 10, 17, 25, 31), excitation radiation is directed onto a carrier unit (5, 13, 20, 26, 33) which is in contact with the sample liquid and which has immobilized molecules of a sensor dye that is sensitive to the analyte, b) a portion of luminescence radiation of the sensor dye, this radiation is induced by the excitation radiation, is applied to a radiation detector (4, 14, 21, 28, 34,35) in order to generate an output signal therefrom, and c) an evaluation routine ascertains the analyte concentration from the detector output signal, wherein a dependence of a property of the luminescence radiation on the concentration of the analyte in the sample liquid is used, characterized in that d) dependence of the examined property of the luminescence radiation on an exchange interaction between the individual molecules of the sensor dye is used to ascertain analyte concentration, wherein the exchange interaction takes place when the molecules of the sensor dye interact with the particles of the analyte. An optode designed to carry out the method is also proposed.

The invention discloses a method for generating an individual transcranial brain atlas, which can project the invisible atlas information in the brain onto the visible scalp surface, so that the originally separated operation space and utility space are fused together. Aiming at the problem of applying the transcranial brain atlas to guide the individualized placement of transcranial devices, the present invention further provides a method for generating a transcranial brain atlas based on individual characteristics and a navigation system. Experimental results show that the invention can effectively improve the coverage accuracy of the near-infrared measurement of the optode interest brain area and the consistency of measurement positions in different human epicortex, thereby improving the sensitivity of the brain activity induced by the near-infrared technology detection task.

An in vitro sensor point-of-care sensor including a substrate, a sensing system, and a reference system. The substrate can include a first cavity and a second cavity. The sensing system can be disposed within the first cavity and include an optode membrane, a selectively-permeable membrane, and a plurality of microbeads. The optode membrane can be sensitive to an analyte in the biological fluid. The selectively-permeable membrane can cover an opening of the first cavity. The plurality of microbeads can be associated with at least one of the optode membrane and the selectively-permeable membrane. The reference system can be disposed within the second cavity.

In order to realize simultaneous measurement of temperature and calcium ion concentration, the invention provides a temperature and calcium ion concentration two-parameter sensor based on an optical fiber inner cavity coarse cone interference structure. An inner cavity coarse cone structure is manufactured through optical fiber fusion discharge, and the end face of an optical fiber is modified with a calcium ion photoelectrode film in cooperation with a dilution spraying method. And the required optical fiber temperature and calcium ion concentration double-parameter sensor is manufactured. The sensor has the beneficial effects that the optical fiber interference structure is matched with the calcium ion photoelectrode, so that electrical logging interference of a traditional electrochemical method is avoided; the device is good in structural mechanical strength and reliable in stability; a three-beam interference structure can be realized, so that spectral subdivision is realized, and the measurement accuracy is improved.

An in vitro sensor for point-of-care detection of at least one analyte or reaction product includes an inert, impermeable substrate, a sensing system, and a reference system. The substrate includes a first transparent surface oppositely disposed from a second surface and first and second cavities. Each of the first and second cavities defines an opening at the second surface. The sensing system is disposed in at least a portion of the first cavity and includes an analyte-detection optode membrane, an analyte-permeable membrane, and a plurality of non-transparent microbeads associated with at least one of the analyte-detection optode membrane and the analyte-permeable membrane. The analyte-permeable membrane is layered upon the analyte-detection optode membrane and covers the opening of the first cavity. The reference system is disposed in at least a portion of the second cavity.