38 results about "Optode" patented technology

A method for measuring in non-invasive manner the concentration of blood constituents by which backscattered light is measured under the action of ultrasonic radiation focused towards the inside of a central blood vessel. A light source and detection unit are arranged to detect the backscattered light on the skin surface above the blood vessel. The target tissue is illuminated by two discrete optical wavelengths. An average light intensity distribution is detected over the length of a pulse. The distribution is Fournier transformed, and the largest Fournier components and spectral position are determined in relation to the frequency of the ultrasonic radiation. The component concentration in the blood vessel is calculated taking into account the volume of the ultrasonic focus contributing to the signal and blood flow rate.

Plasticizer-free ion-detecting sensors for detecting a target ion in a sample are provided. The sensor comprises a plasticizer-free copolymer comprised of polymerized units of methacrylate monomers and a polymerizable ion exchanger, wherein the methacrylated monomers have pendent alkyl groups of different length and wherein the functionalized ion-exchanger is grafted into the copolymer through covalent linkages. The ion exchanger comprises a C-derivative of a halogenated closo-dodecacarborane anion having a polymerizable moiety. Sensors of this invention include carrier-based ion-selective electrodes or optodes such as thin film ion-specific optodes, particle-based optodes, or bulk optodes.

The invention relates to a photopole biomolecular sensor, in particular to a graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor. The graphene oxide fiber bragg grating-based gold nanoshell LSPR photopole biosensor comprises a fiber core, a fiber cladding and a fiber coating layer, wherein a large-angle tilting fiber bragg grating is arranged at the tail end of the fiber core; a coating layer on the surface of the cladding of the large-angle tilting fiber bragg grating is completely removed; the end surface of the tail end of the large-angle tilting fiber bragg grating is coated with a silver reflective film; a silane layer is arranged on the surface of the cladding of the large-angle tilting fiber bragg grating; a gold nanoshell particle layer is fixed on thesurface of the silane layer; a graphene oxide layer is adsorbed to the surface on which the gold nanoshell particle layer is fixed; and a biomolecular sensitive layer is fixed on the surface of the graphene oxide layer. By adopting the photopole biosensor structure provided by the invention, the operating distances of LSPR excited by a light wave evanescent field and biomolecules can be increased,and the photopole biosensor structure is convenient to integrate and use, has very high robustness and can be applied to the field of biology, medicine, environment monitoring, food safety, life science and the like.

The invention relates to a photoelectrode biomolecular sensor, in particular to a broadband interference type photoelectrode biomolecular sensor and method of a graphene oxide fiber bragg grating. Thesensor comprises an optical fiber core, an optical fiber cladding, an optical fiber coating layer, and a large-angle inclined fiber bragg grating arranged in the middle of the optical fiber core; coating layers of the middle section and the rear section of an optical fiber are completely removed, the tail end surface of the rear section of the optical fiber is plated with a silver reflecting film, the distance between the rear end of the large-angle inclined optical fiber grating and the silver reflecting film at the tail end of the optical fiber ranges from 30 mm to 60 mm, and an optical fiber micro Michelson interference cavity is formed. A silane layer, a nano gold shell particle layer, a graphene oxide layer and a biomolecule sensitive layer are arranged on the cladding surface from the starting end of the large-angle tilted fiber bragg grating to the tail end of the optical fiber. The photoelectrode biomolecular sensor structure can be used to increase the action distance betweenLSPR excited by a light wave evanescent place and biomolecules, is convenient to integrate and apply, has very high robustness, and can be applied to the fields of biomedicine, life science, environmental monitoring and the like.

An in vitro sensor for point-of-care detection of at least one analyte or reaction product includes an inert, impermeable substrate, a sensing system, and a reference system. The substrate includes a first transparent surface oppositely disposed from a second surface and first and second cavities. Each of the first and second cavities defines an opening at the second surface. The sensing system is disposed in at least a portion of the first cavity and includes an analyte-detection optode membrane, an analyte-permeable membrane, and a plurality of non-transparent microbeads associated with at least one of the analyte-detection optode membrane and the analyte-permeable membrane. The analyte-permeable membrane is layered upon the analyte-detection optode membrane and covers the opening of the first cavity. The reference system is disposed in at least a portion of the second cavity.

A water-soluble lithium salt is added as a tracer substance along with a water treatment chemical to water to be treated. The concentration of lithium ions is electrochemically or optically measured using a lithium ion sensitive substance, so as to perform concentration control of the water treatment chemical added to water to be treated. An ion selective electrode, ion selective field effect transistor, or ion optode may be employed to perform the electrochemical or optical measurement using a lithium ion sensitive substance.

The present invention relates to π-conjugated fluoroionophores, methods for their preparation, and their use and a method for determining an alkali ion.

Fluoroionophoric compounds of the general formula I are described

Ionophore-π-Linker-Fluorophore  (I)

wherein

the Ionophore is an anilino containing crown ether or cryptand with one or more anilino donor moieties as electron donors, forming a stable complex with an alkali metal ion

the π-Linker is an aromatic or heteroaromatic conjugative linking moiety, and the Fluorophore is an electron acceptor moiety.

Variation of the ionophoric unit offers a broad spectrum of detectable K⁺ and Na⁺-concentrations, ranging from high concentration around 800 mM down to very low concentrations around 3 mM.

The fluoroionophores have great potential for application in fluorescent optode system based blood analyzing equipment for methods and kits for the determination of K⁺ and Na⁺ concentrations in biological systems, either in vitro or in vivo, using embodiments of the disclosed fluoroionophores.

A composition comprising a pH indicator, a polymerizable group, and a spacer therebetween. The polymerizable group can be acrylate or methacrylate and the spacer can be an oxyalkayl group, an oxypropyl group, or an oxybenzoyl group. The composition can be polymerized to copolymers to form indicating polymers and optodes.

An improved luminescent optode is disclosed that is capable of conducting a self-test to determine the quality of the optode's measurement of the concentration of a quenching molecule in a fluid, along with a method for conducting the self-test.

Disclosed herein are compositions comprising an oblong optode sensing agent. The oblong optode sensing agent comprises a core and a semipermeable membrane, wherein the core comprises one or more sensors configured to bind to an analyte. In addition, methods of making and detecting the oblong optode sensing agents are disclosed.

The invention provides a multichannel wireless heredity photostimulation system and method. The system comprises an upper computer, a photostimulator and an array type stimulating light pole, wherein the photostimulator comprises a plurality of stimulating channels, different stimulating channels electrically communicate with different zones of the array type stimulating light pole, the upper computer is used for setting photostimulation parameters, the photostimulation parameters comprise frequency of pulses, duty ratio, stimulation time and one or more stimulating channels, the upper computer is in wireless connection with the photostimulator, and the photostimulator is used for receiving the photostimulation parameters set by the upper computer and outputting electric pulse signals to zones of the array type stimulating light pole electrically communicating with the stimulating channels in the photostimulation parameters. According to the method and the system, stimulated zones can be independently selected.

The present disclosure provides a device for monitoring and visualising electrical activity of biological tissue. The device uses a sensor arrangement comprising a matrix of conductive sensors and a transducing element for transducing electric fields in a variation of an optical property. In use, electric fields generated by the biological tissue are sensed by the sensor arrangement and transduced by the transducing element for optical imaging.

In order to realize real-time monitoring of calcium ion concentration, the invention provides a calcium ion detection photoelectrode based on special optical fiber surface film modification. According to the invention, the required calcium ion concentration sensor is produced by adopting a polymer-based optical fiber and calcium ion photoelectrode end surface modification method.

An in vitro sensor point-of-care sensor including a substrate, a sensing system, and a reference system. The substrate can include a first cavity and a second cavity. The sensing system can be disposed within the first cavity and include an optode membrane, a selectively-permeable membrane, and a plurality of microbeads. The optode membrane can be sensitive to an analyte in the biological fluid. The selectively-permeable membrane can cover an opening of the first cavity. The plurality of microbeads can be associated with at least one of the optode membrane and the selectively-permeable membrane. The reference system can be disposed within the second cavity.

In order to realize simultaneous measurement of temperature and calcium ion concentration, the invention provides a temperature and calcium ion concentration two-parameter sensor based on an optical fiber inner cavity coarse cone interference structure. An inner cavity coarse cone structure is manufactured through optical fiber fusion discharge, and the end face of an optical fiber is modified with a calcium ion photoelectrode film in cooperation with a dilution spraying method. And the required optical fiber temperature and calcium ion concentration double-parameter sensor is manufactured. The sensor has the beneficial effects that the optical fiber interference structure is matched with the calcium ion photoelectrode, so that electrical logging interference of a traditional electrochemical method is avoided; the device is good in structural mechanical strength and reliable in stability; a three-beam interference structure can be realized, so that spectral subdivision is realized, and the measurement accuracy is improved.