The invention relates to the technical field of medical nursing instruments, in particular to a medicine spraying device for ear-nose-throat clinical nursing. The medicine spraying device comprises agrip, a base, an outer barrel, a spherical sleeve and a medicine discharging pipe, the base is provided with a clamping groove matched with the grip, an air pump is fixedly connected to the upper portion inside the grip, an air exhaust pipe is fixedly connected to one end of an air exhaust opening of the air pump, a spherical block is fixedly connected to the lower end face of the outer barrel through a connecting rod, a cavity is formed in the lower portion of the spherical block, the spherical sleeve sleeves the exterior of the spherical block, the lower portion of the spherical sleeve is inthreaded connection with a medicine barrel through a connecting barrel, a sliding barrel is inserted into the left end of the outer barrel, and the left end of a third corrugated pipe is fixedly connected with an atomizing spray nozzle. The medicine spraying device is reasonable in structural design, when a doctor needs to appropriately adjust a medicine spraying angle according to actual conditions, under the effect of gravity of a clump weight, the medicine barrel is always kept vertical to guarantee that medicinal liquid can be always sucked and be sprayed once a button is pressed, medicine spraying is stopped once the button is released, and the medicine spraying device is quite convenient.