The invention discloses a low-temperature long-term storage box for drug classification. The low-temperature long-term storage box comprises a cabinet body and a base which is located below the cabinet body; the interior of the base is hollow, and air inlets are formed in the two sides of the base; and an opening communicating with the interior of the cabinet body is formed in the center of the top of the base. According to the low-temperature long-term storage box for drug classification, through arrangement of an electronic lock, drug taking by non-medical staff is effectively avoided, the safety is high, and the temperature, humidity and the weight situation of stored drugs inside all drawers inside a box body can be real-timely detected through a single chip microcomputer; air inside the box body is replaced through an exhaust fan, and thus it is ensured that the air humidity for drug storage is constant; independent low-temperature and constant-temperature control over all the drawers is achieved through a semiconductor refrigeration technology to ensure the situation that the drugs can be stored for a long term, it is ensured that all the drugs each have the most suitable storage temperature, and drug properties are not influenced between the drugs; and meanwhile a wireless transmitting function is achieved, related personnel can accurately master the storage capacity, temperature and humidity information, and use is convenient.