48 results about "Dose verification" patented technology

Various embodiments of the present invention provide methods and systems for deterministic calculation of radiation doses, delivered to specified volumes within human tissues and organs, and specified areas within other organisms, by external and internal radiation sources. Embodiments of the present invention provide for creating and optimizing computational mesh structures for deterministic radiation transport methods. In general these approaches seek to both improve solution accuracy and computational efficiency. Embodiments of the present invention provide methods for planning radiation treatments using deterministic methods. The methods of the present invention may also be applied for dose calculations, dose verification, and dose reconstruction for many different forms of radiotherapy treatments, including: conventional beam therapies, intensity modulated radiation therapy (“IMRT”), proton, electron and other charged particle beam therapies, targeted radionuclide therapies, brachytherapy, stereotactic radiosurgery (“SRS”), Tomotherapy®; and other radiotherapy delivery modes. The methods may also be applied to radiation-dose calculations based on radiation sources that include linear accelerators, various delivery devices, field shaping components, such as jaws, blocks, flattening filters, and multi-leaf collimators, and to many other radiation-related problems, including radiation shielding, detector design and characterization; thermal or infrared radiation, optical tomography, photon migration, and other problems.

Disclosed is a phantom for dose verification for intensity-modulated radiation therapy having a base of substantially tissue-equivalent material and a two-dimensional array of cavities formed in the base with each the cavities being configured and dimensioned to receive a radiation detector.

The invention provides a system and method for three-dimensional dose verification in radiosurgery. First a patient's image data and radiotherapy planning data are led in through a data management module, a patient's actual illuminated three-dimensional dose field distribution during the treatment is quickly reconstructed by utilization of a two-dimensional field size dosage collecting module and a three-dimensional dose inversion module; three-dimensional evaluation analysis is performed on a irradiation dose and a planning dose through a dose evaluation module; whether an error is in a permissible range is judged; if the error is in the permissible range, the patient is treated according to a radiotherapy plan, or else the radiotherapy plan is adjusted or a radiosurgery accelerator is subjected to quality control detection, irradiation is not performed on the patient until the dose verification passes, and the consistency between the irradiation dose and the planning dose is guaranteed finally. According to the system and method for three-dimensional dose verification in radiosurgery, the shortcoming of two-dimensional plane dose verification of using water instead of a person prior to existing treatment is overcome, and precise dose verification of three-dimensional space dose field distribution in the patient prior to fractionated treatment and during the fractionated treatment can be implemented.

The invention discloses a cloud-computing based dose verification system and method of tumor radiotherapy. The system comprises a user terminal equipment, a cloud computing server, a local therapy planning system, a computer, an HDFS data storage server and a medical linear accelerator. According to the system and method, EPID information collection is separated from dose analysis and comparison, and part which needs computing and analyzing is transferred to the server based on cloud computer; the equipment at the user end only makes therapy plans, collects, pre-processes and transmits EPID images and receives and display analysis results; and Gamma analysis between to-be-compared dose distribution and reference dose distribution is accelerated. The parallel operation mechanism of cloud computing is used, so that planning dose verification of tumor radiotherapy can be greatly accelerated, time of clinical dosimeter verification is reduced, and the efficiency of radiotherapy is improved.

The invention discloses an offline dose verification method based on improved CBCT (cone beam computed tomography) images. The offline dose verification method includes: subjecting the CBCT images of an individual patient to scatter correction on the basis of Monte-Carlo simulation to acquire a first CBCT image; rectifying the first CBCT image with a planned CT (computed tomography) image to acquire target-region deformation field information; verifying outline information of the planned CD image according to the target-region deformation field information, transplanting the verified outline information to the CBCT images to acquire a second CBCT image; establishing HU-ED calibration curves of the CBCT images according to average HU value of a particular tissue area of the individual patient in the second CBCT image and ED value of a particular tissue area of the planned CT image; performing dose calculation and planned validation on the basis of the second CBCT image, the HU-ED calibration curves, the planned CT and standard CT-ED calibration curves. By the technical scheme, treatment time and cost of the patient can be saved, and accurate adaptive radiation therapy and individual radiation therapy are realized.

We disclose a radiotherapy apparatus with a dose verification system in which the portal image is displayed against a background of a better-quality image diagnostic image, such as a two-dimensional radiograph, an ultrasound image, or a section taken from a three-dimensional magnetic-resonance image, cone-beam CT image, or the like.

The invention relates to a verification method for ensuring accurate operation of intensity modulated radiation therapy (IMRT). The method comprises the following steps: designing a plan, printing the model of a patient by using a 3D printing technology, scanning the model under the same positioning condition and scanning condition, transmitting the scanned model to a TPS (Therapy Planning System), calling an IMRT therapy plan to be verified, completely copying relevant therapy data of the plan to the model, placing the model on an accelerator therapy bed, adjusting the measurement points of the model to isocenter positions by means of laser rays, and performing absolute dose verification and relative dose verification. The method has the advantages: the verification model is prepared by adopting the 3D printing technology, and the model is completely consistent with the patient in size, physical density and electronic density, so that the precision and the accuracy of the absolute dose verification and the relative dose verification are improved.

The present invention discloses a three-dimensional dosage verification method of nuclear magnetism guidance radiation therapy based on MRI-Only. The method comprises the following steps: selecting radiation therapy image information of a patient to be verified and a corresponding patient's radiation therapy plan, preparing and storing gel dosimeter phantom and a calibration phantom, scanning the gel dosimeter phantom to obtain the magnetic resonance imaging (MRI) images of a corresponding phantom, sending the magnetic resonance imaging (MRI) images of the corresponding phantom to a treatment plan system (TPS), irradiating and scanning the calibration phantom to obtain a calibration curve, making the radiation therapy plan of the gel dosimeter phantom, scanning the gel dosimeter phantom after irradiation, converting the images to an adsorbed dose graph, assessing results of measurement and calculation of the gel dosimeter phantom, and executing the patient's radiation therapy plan if the results of measurement and calculation of the gel dosimeter phantom accord with clinical assessment requirements. The three-dimensional dosage distribution of the nuclear magnetism guidance radiation therapy can be accurately measured and can be used for three-dimensional dosage verification to facilitate improvement of the radiation therapy effect.

The invention discloses a beam dose distribution measurement device, which comprises a first-layer detector, a second-layer detector, a third-layer detector, a collimator and a signal processing module, wherein the first-layer detector, the second-layer detector and the third-layer detector are arranged in an overlapped mode sequentially; the collimator is arranged above the first-layer detector; and the first-layer detector, the second-layer detector, the third-layer detector and the collimator are all electrically connected with the signal processing module. the beam dose distribution measurement device disclosed by the invention has the advantages that the dose verification time can be reduced; the space distribution verification precision can be improved; arrangement of huge and expensive online PET is avoided; a postoperative PET scanning procedure is removed; the dose space distribution verification precision can reach 1 mm; the preoperative verification time is compressed to 15 m; the online monitoring time is completely synchronous with the treatment; no extra verification time is needed; and the verification time can be greatly reduced.

The invention provides an adult chest and abdomen dose verification dynamic phantom. The phantom comprises a chest and abdomen phantom body and a motion measurement and control system; the chest and abdomen phantom body is made of a material equivalent to a material with human body CT values and comprises human muscle tissue, spinal bone tissue and lung tissue, the whole phantom body is formed bycombining slices, an EBT3 dosimetry development-free film can be clamped between every two slices, and the dose space distribution of the positions of interest is obtained through multiple films; lungmotion insertion rods are arranged in the lung tissue and comprise the simulated tumor insertion rod, the four-dimensional CT quality control insertion rod and the like; the motion measurement and control system comprises an insertion rod motion platform and a chest wall motion platform, a driving device is controlled by an upper computer and connected with the insertion rods, and corresponding action is generated to simulate 3D breathing motion and chest-wall up-down motion of the human body. The phantom can provide a research tool for radiotherapy dose distribution and dose verification inclinical research of motion organs.

The invention discloses a multi-mode guided adaptive radiotherapy system. The system mainly comprises two kilovolt-level X-ray imaging systems, an infrared positioning and tracking system and a megavolt-level X-ray imaging system. According to the multi-mode guided adaptive radiotherapy system of the invention, different modes of image and dose signals are integrated, so that the two externally arranged X-ray imaging systems, the infrared positioning and tracking system and the megavolt-level X-ray imaging system which is mounted on an accelerator can be integrated in the multi-mode guided adaptive radiotherapy system; tumor location real-time tracking correction and irradiation dose verification can be simultaneously performed during a treatment process; dynamic adjustment can be realized; the problem of the position and shape change of a target area in radiotherapy can be solved in real time; a treatment plan is update according to the latest anatomical structure of a patient beforeeach round of treatment; the position of the patient and errors caused by target area movement collection can be timely adjusted during the radiotherapy, so that current and subsequent treatment can be guided; an accurate prescription dose can be allocated to the tumor target area; and therefore, adaptive radiotherapy can be realized.

The invention belongs to the field of radiotherapy and cloud computing services, and relates to a cloud Monte Carlo dose verification analysis method, a device, a storage medium and a system thereof.The method of the present invention comprises the steps of: (1) inputting a first radiotherapy plan, wherein the dose calculation result in the first radiotherapy plan is a first dose calculation result; (2) dose calculation is carried out based on a Monte Carlo calculation model: (3) the steps of interpolating, smoothing and re-sampling are performed on the dose distribution in the second dose calculation result to obtain a third dose calculation result; and (4) the dose distribution of the third dose calculation result from the Monte Carlo calculation is compared with the dose distribution of the first plan. The cloud Monte Carlo dose verification analysis method of the invention combines the cloud Monte Carlo with an optimized scheduling method, which can greatly improve the calculationefficiency and provide a satisfactory solution for the user; and the accuracy of the Monte Carlo calculation and the stability of radioactive source can be checked at any time to ensure the quality of the patient's exposure.

The invention provides a dosage verification method and system based on artificial intelligence. The method comprises the steps of: acquiring the radiation field area, the radiation field modulation complexity and the blade motion and dosage characteristic parameters of an intensity modulated radiation therapy plan; establishing a regression model based on a machine learning model, taking the characteristic parameters as an input sample of the machine learning model, and setting a standard gamma passing rate as an output of the machine learning model; establishing a classification model basedon a machine learning model, taking feature parameters as an input sample of the machine learning model, and taking the standard gamma passing rate as an output of the machine learning model; performing sample training to obtain a regression model and a classification model for optimal prediction, predicting the gamma passing rate of the to-be-verified characteristic parameters according to the optimal prediction model, and predicting and classifying clinical intensity modulated radiation therapy plans. According to the invention, the problems of long consumed time and high labor cost of the existing radiotherapy dosage verification work can be solved, and the efficiency and the quality can be improved.

The invention discloses a method for realizing automatic dose verification based on an accelerator log file. The method comprises the steps: collecting 135 chest intensity modulation plans on a Villian Eclipse planning system, and the chest intensity modulation plans comprise 584 radiation fields; and before a radiotherapy plan is implemented, implementing intensity modulated verification by using a linear accelerator delivery plan, and besides, collecting log files in the linear accelerator plan delivery process. A deep learning algorithm is used, the log file in the accelerator delivery process is used as the input of a model in a flux graph form, a gamma passing rate prediction model under different threshold standards is established, and the accuracy of the prediction model is verified. The flux graph formed based on the accelerator log file serves as input to train the gamma passing rate prediction model, real delivery parameters are considered, the individualized dose verification result can be accurately predicted, automation of dose verification before treatment is achieved, the dose verification efficiency is improved, and a physician is allowed to have more time to pay attention to the reason of dose verification failure.

The invention discloses a radiotherapy dose measurement system based on a fluorescent film and an optical fiber probe, comprising a dosimeter, a CCD(Charge Coupled Device) camera, a light intensity receiver, and a computer. The dosimeter is horizontally placed on the treatment couch and located underneath the head of an accelerator; the CCD camera is located above the dosimeter; the dosimeter is connected with the light intensity receiver through an optical fiber; the light intensity receiver is connected with the computer through a data cable; the computer is connected with the CCD camera through a data cable. According to the radiotherapy dose measurement system based on the fluorescent film and the optical fiber probe, the system has a high spatial resolution and a high cost performancewhile the accuracy of a dose measurement is guaranteed; the present invention has a plurality of applications such as verifications of radiation field size and multi-leaf collimator(MLC) moving accuracy, and dose verifications of accelerator daily morning analyzer and patient treatment plan.

The invention discloses an implementation method for a dose verification model based on 3D printing, comprising the following steps: A) loading CT.MR data, and importing the CT.MR data into a 3D precise radiotherapy platform; B) determining an end point to be punched; C) selecting measuring equipment; D) generating a hole from the outermost layer surface of the dose verification model to the punching end point according to the shape and size of the measuring equipment; E) generating a punched dose verification model; and F) exporting the punched dose verification model through the 3D precise radiotherapy platform, and printing by adopting a 3D printer. The invention also relates to a device for realizing the implementation method for the dose verification model based on 3D printing. According to the implementation method and the device of the invention, the degree of dependence of radiotherapy on doctor experience can be reduced, the operating cost of a hospital is reduced, the stability in the radiotherapy process and the comfort level of patients are improved, and part of expenses of a patient during radiotherapy are reduced.

The invention discloses a radiotherapy dose verification method and a device and computer equipment, relates to the technical field of medical treatment, and can solve the problem that verification isnot accurate enough when dose verification is carried out on a radiotherapy plan. The method comprises the steps of reading to-be-verified target dose data according to a preset reading rule; determining a radiotherapy plan type corresponding to the target dose data; calculating a gamma passing rate corresponding to the target dose data; and comparing the gamma passing rate with a preset threshold corresponding to the radiotherapy plan type, and if it is determined that the gamma passing rate is greater than or equal to the preset threshold, determining that the target dose data passes verification. The method and the device are suitable for effectively verifying the radiotherapy dose in the radiotherapy plan.

The invention discloses a beam dose distribution measurement device, which comprises a first-layer detector, a second-layer detector, a third-layer detector, a collimator and a signal processing module, wherein the first-layer detector, the second-layer detector and the third-layer detector are arranged in an overlapped mode sequentially; the collimator is arranged above the first-layer detector; and the first-layer detector, the second-layer detector, the third-layer detector and the collimator are all electrically connected with the signal processing module. the beam dose distribution measurement device disclosed by the invention has the advantages that the dose verification time can be reduced; the space distribution verification precision can be improved; arrangement of huge and expensive online PET is avoided; a postoperative PET scanning procedure is removed; the dose space distribution verification precision can reach 1 mm; the preoperative verification time is compressed to 15 m; the online monitoring time is completely synchronous with the treatment; no extra verification time is needed; and the verification time can be greatly reduced.

The invention provides an ultra-long-target-region multi-center volumetric intensity-modulated arc radiation therapy verification die body and method. A comparison analysis is carried out on dose distribution obtained by measurement of multi-center ultra-long-radiation-field volumetric intensity-modulated arc radiation therapy and dose distribution obtained by planning to verify accuracy of multi-center ultra-long-radiation-field volumetric intensity-modulated arc radiation therapy plan transmission, especially an error of multi-center transmission dose. According to the invention, on the basis of dose verification on the ultra-long-target-region multi-center volumetric intensity-modulated radiation therapy plan, feasibility of the volumetric intensity-modulated radiation therapy technology for a total-brain or total-spinal ultra-long-target-region is exploited, so that the treatment efficiency and treatment accuracy of total-brain or total-spinal ultra-long-target-region patients areimproved, the radiation therapy complication occurrence is reduced, and the living quality of the patient is improved.

A system, method and device for brachytherapy treatment verification is described herein. The verification may be in real time and may provide verification of one or more of dose, source position, dwell time and source activity. In one embodiment the invention provides a method for verifying a brachytherapy radiation treatment including processing a distribution of exposure to a brachytherapy radiation source of a two dimensional imaging array to determine a region of high exposure; obtaining one or more distribution of exposure profiles through the region of high exposure; determining a region of high value in the one or more distribution of exposure profiles; and using the determined region of high exposure and / or high value to calculate one or more brachytherapy radiation source position and / or one or more brachytherapy radiation source distance to thereby verify at least a part of the brachytherapy radiation treatment.

The invention provides a dose verification die body model manufacturing method, a device thereof and a system, and the manufacturing method comprises the steps: S101, building a three-dimensional model according to the image data of a patient, and generating a dose detector model; S102, forming a space corresponding to the shape of the dose detector model in a patient target area and a dangerous organ of the three-dimensional model to generate a first three-dimensional model, and marking an area associated with the patient target area on the surface of the first three-dimensional model; and S103, cutting the first three-dimensional model to form a second three-dimensional model, performing 3D printing on the second three-dimensional model to obtain a carrier model, assembling the carrier model, and putting a dose detector into the carrier model to form the dose verification die body model. The model and the patient are kept consistent, the influence of external factors is reduced, thedifference between the verification dose and the actual dose of the patient is reduced, accurate instructions are achieved by controlling the dose endangering organs, an incident point, an area and direction of rays are determined in the mode of marking the associated area of the target area, and dose irradiation is facilitated.

The invention belongs to the technical field of radiotherapy radiation dose calculation, and relates to a radiotherapy dose verification method based on GPU parallel Monte Carlo dose calculation and machine learning. The method comprises the following steps: (1) data input: inputting an organ and endangered organ delineation CT image and a DVH image of a target area of a patient, material density,material information, source parameters, geometric information of a die body and the like; (2) particle input simulation: employing a CUDA framework of the NVIDIA company, employing a GPU of a display card for parallel calculation, employing a Monte Carlo particle transportation principle for particle transportation, and obtaining dose simulation distribution; (3) outputting a simulation result obtained in the step (2) through Monte Carlo of the parallel GPU; and (4) establishing a machine learning model by using the parameters, and verifying an output result in the step (3). Compared with the prior art, the method has the following beneficial effects that the Monte Carlo calculation speed is greatly improved through parallel GPU hardware, the Monte Carlo calculation result is verified through machine learning, the problems of long time consumption and high manpower and material resource cost in dose verification work of patient treatment in existing radiotherapy are solved, the doseverification efficiency can be improved, and the verification cost is reduced.

The invention discloses a preoperative dose verification method and device and radiotherapy equipment. The verification method comprises the steps of S1, carrying out EPID continuous image collection, and extracting an effective image from all images; S2, carrying out image correction on each effective image; S3, enabling each corrected image to be calibrated and corrected, superposing all the images after processing and carrying out weight correction to obtain a corrected fluxgraph; S4, performing Monte Carlo dose calculation through the corrected fluxgraph to obtain reconstructed dose distribution; and S5, comparing the reconstructed dose distribution with TPS calculation, calculating a passing rate according to gamma analysis, and outputting a verification result. According to the method, Monte Carlo dose calculation is adopted as a pixel-to-dose mapping means, and the accuracy is high. And each image is calibrated and corrected frame by frame, so that detail loss caused by acquisition is avoided, dependence on a dose algorithm is reduced, and the reconstruction accuracy is high.

The invention discloses an image and dose integrated device. The image and dose integrated device comprises an amorphous silicon flat plate for image positioning verification, a first linear displacement mechanism for driving the amorphous silicon flat plate to move, an ionization chamber flat plate for dose verification, a second linear displacement mechanism for driving the ionization chamber flat plate to move, and a turnover assembly for connecting the second linear displacement mechanism with a radiotherapy equipment rack, wherein the turnover assembly is used for driving the amorphous silicon flat plate and the ionization chamber flat plate to be arranged in parallel or perpendicular to a ray beam; the first linear displacement mechanism is installed on a fixing portion of the secondlinear displacement mechanism, and the movement direction of the amorphous silicon flat plate is parallel to the movement direction of the ionization chamber flat plate. The first linear displacementmechanism and the second linear displacement mechanism are arranged to control movement of the amorphous silicon flat plate and movement of the ionization chamber flat plate respectively, so that independent control and synchronous control of image positioning verification and dose verification are achieved, the efficiency of image positioning verification and dose verification is improved, and the clinical treatment efficiency and the working efficiency of doctors are improved.

The invention provides a precise dose verification method, device and equipment for tumor patients, including establishing a tumor patient information database; classifying patient sample data in the tumor patient information database, establishing an accurate radiotherapy dose verification evaluation model, and obtaining a dose verification based on patient DVH The normalized QA index of the tumor patient information database is analyzed by the parameter analysis algorithm to obtain the key planning parameters of the tumor patient; the key planning parameters of the tumor patient information database sample are used as input parameters to be input into the patient precision radiotherapy The dose verification and evaluation model is corrected by a recursive algorithm to correct the patient's precision radiotherapy dose verification and evaluation model, and an individualized QA automatic prediction model for precision radiotherapy planning is constructed. The present invention realizes the optimization of the precise radiotherapy dose verification and evaluation model by extracting associated plan parameters and algorithms, and obtains the QA index for precise radiotherapy plan prediction through optimization of the recursive algorithm, thereby realizing accurate QA prediction and high evaluation efficiency.

The invention provides a method for setting a tolerance limit value for monitoring an intensity modulated radiation therapy dose verification process, and belongs to the field of intensity modulated radiation therapy dose verification. The method is insensitive to the distribution of the gamma passing rate in the intensity modulated radiation therapy dose verification process, so that the influence of non-normality on control limit value calculation is reduced. Therefore, the tolerance limit value obtained through the method is more stable and reliable. The tolerance limit value obtained based on the method has good performance in monitoring the intensity modulated radiation therapy dose verification process; an intensity modulated radiation therapy plan with the out-of-control problem can be effectively detected, and in addition, the workload of a radiation therapy physicist for investigating the "problem" plan is reduced.

The present invention relates to a 4D dose reconstruction device, and discloses a dose reconstruction method based on tumor motion tracking and radiotherapy, including: step S1, obtaining the tumor centroid motion core, and obtaining the tumor centroid in the LR direction, CC direction and AP direction Time function; step S2, obtain the motion parameters of the tumor center of mass according to the time function in the LR direction and the CC direction in step S1; step S3, control the driving module to drive the dose verification device LR and CC to move in two directions according to the motion parameters in step S2 , step S4, the influence of AP direction movement on the dose is realized by real-time online correction of the percentage depth dose PDD parameter method, and finally realizes the 4D dose reconstruction of the dose verification device and obtains the reconstructed 4D dose data. The introduction of the three-dimensional movement factor of the tumor in the present invention can effectively improve the radiotherapy plan of the tumor, make the final treatment of the patient closer to the actual situation, and greatly improve the safety and effectiveness of the radiotherapy of the tumor.

The invention relates to minimally invasive tumor treatment, in particular to an intracranial tumor radioactive particle implantation training and dose verification method, which comprises the following steps of puncturing a tumor substitute by using a dosimeter implanter, implanting a dosimeter at a specific point, puncturing brain tissue equivalent filler around the tumor substitute, and implanting the dosimeter at multiple points; making a preoperative plan, designing a proper puncture path according to the preoperative plan, determining a puncture layer and a specific position, and using a puncture needle for puncturing the tumor substitutes; implanting particles according to a preoperative plan after all the puncture needles puncture the implantation positions, taking out all the dosimeters and reading actual doses; making a postoperative plan, and comparing the actual dose with the particle dose for verification; according to the technical scheme provided by the invention, the defects that the intracranial tumor puncture environment cannot be truly simulated and the particle dose cannot be effectively verified in the prior art can be overcome.