35 results about "Anti acetylcholinesterase" patented technology

The invention discloses preparation and application of total alkaloids extract and effective components in peganum plant seeds. The peganum plant (comprising harmel, multisectum peganum and peganum nigellastrum) seeds are heated, refluxed and extracted by ethanol, dissolved along with heat, acidulated by added 2 to 10 percent hydrochloric acid, and basified by ammonia water to separate out sediment; and the sediment is dried to obtain the total alkaloids extract mainly containing dehydrogenized peganine and peganine according to a proportion of between 0.18 to 1 and 4.30 to 1, wherein the content of the total alkaloids is more than 50 percent. The total alkaloids extract is separated by chromatography to obtain ten effective monomer components such as the dehydrogenized peganine, the peganine, and the like. Through thin layer chromatography and biological self-developing analysis, the total alkaloids extract and the effective monomer components thereof have the effect of resisting activity of acetylcholine esterase, and can be used for preparing medicament for resisting the activity of the acetylcholine esterase and medicament for treating neurodegenerative diseases.

The present invention relates to new substituted carbamic acid quinoline-6-yl esters of formulae 1 and 2 where R1=alkyl, aryl; R2=H, alkyl, aralkyl useful as acetylcholinesterase inhibitors, and which show potent antiacetylcholinesterase activity and have potential therapeutic use for prevention or cure of acetylcholinesterase related disorders including peripheral as well as central nervous system.

The invention relates to a compound of formula I or pharmaceutically acceptable salt and a preparation method thereof, as well as a drug composition containing the same. The compound of formula I is novel piperazine and homopiperazine derivative, which can be used for preparing cervical cancer-treating medicine, anti-acetylcholinesterase and butyrylcholinesterase medicine, and medicine for treating staphylococcus aureus infection.

The invention discloses a catechin derivative with the structure represented by formula (I) shown in the description. In the formula (I), R1 and R2 are respectively independently selected from H, OH and OCH3. The catechin derivative with the structure represented by formula (I) is extracted from Zijuan tea for the first time. The catechin derivative has a strong acetylcholinesterase inhibition effect, and the IC50 value of the catechin derivative can reach 2.33 [mu]M, 11.33 [mu]M and 62.10 [mu]M, so the catechin derivative has an acetylcholinesterase activity inhibition effect, has wide application prospect in finding and preparation of anti-acetylcholinesterase medicines, and provides a research direction for researches of the preparation of the anti-acetylcholinesterase medicines.

The invention belongs to the technical field of fungal extraction compounds, and in particular relates to a pyridine-containing novel skeleton heteroterpenoid compound and its preparation method and application. The compound has significant anti-acetylcholinesterase activity through experimental verification, and has good development prospects in the preparation of drugs for the prevention and / or treatment of diseases mediated by acetylcholinesterase; and it is reproduced by using modern microbial fermentation engineering technology, without Raw materials are worry-free, and at the same time, they have the advantages of not destroying the ecological balance and easy industrialization. They are renewable drug resources with development prospects, and provide abundant raw materials for the research and development of marine microbial products and marine microbial drugs.

The invention relates to a pregabalin derivative shown in formula I and application thereof in medicine for resisting senile dementia. Acetylcholinesterase in vitro test model shows that the pregabalin derivative has remarkable acetylcholinesterase resistance activity so as to be used for preparing the medicine for resisting senile dementia. The pregabalin derivative has the chemical structural formula shown by the formula I, and R in the formula is defined by the specification. Formula I.

The invention relates to a glucosamine-containing 1,3,4-thiadiazole derivative and a synthesis method of the lucosamine-containing 1,3,4-thiadiazole derivative. The method comprises the following steps: reacting 2-desoxy-2-isorhodanate-1,3,4,6-tetra-O-benzyl-beta-D-glucopyranose with hydrazine hydrate to synthesize an intermediate glycosyl thiosemicarbazide, and reacting with substituted aldehyde and a Fe<3+> compound to synthesize the N-(5-substituted-1,3,4-thiadiazolyl-2-yl)-1,3,4,6-tetra-O-benzyl-2-desoxy-beta-D-glucosamine. The synthesis method is simple and safe to operate, and has the advantages of small environmental pollution, high yield and simple after-treatment. The synthesized compound has a strong inhibiting effect on acetylcholinesterase, and has wide application prospects in the aspect of preparation of anti-acetylcholinesterase drugs.

The invention discloses a huperzia serrata endophytic fungus Eurotiaceae Penicillium L10Q37 strain which is collected in China Center for Type CultureCollection on January 12, 2014 with a collection number of CCTCC NO. M2014021. A fermentation product, a fermentation liquor extract and a thallus extract, obtained by fermenting the fungus, have anti-acetylcholine activity and can be used for preparing drugs for treating Alzheimer's disease.