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65 results about "2-Deoxy-D-glucose" patented technology

2-Deoxy-d-glucose is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such; it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate intracellularly (with exception of liver and kidney); thus, labelled forms of 2-deoxyglucose serve as a good marker for tissue glucose uptake and hexokinase activity. Many cancers have elevated glucose uptake and hexokinase levels. 2-Deoxyglucose labeled with tritium or carbon-14 has been a popular ligand for laboratory research in animal models, where distribution is assessed by tissue-slicing followed by autoradiography, sometimes in tandem with either conventional or electron microscopy.

Compositions and methods for timed release of water-soluble nutritional supplements

InactiveUS20050181047A1Great flexibility in designingIncrease in plasma levelSulfur/selenium/tellurium active ingredientsFood shapingGreek letter betaGlucosamine Sulfate
The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain glucosamine sulfate, beta-(1,4)-2-amino-2-deoxy-D-glucose, and chondroitin, (C14H19NO14SNa2)n; N-acetylchondrosanine (2-acetamide-2-deoxi-D-galactopiranose) and D-gluoronic acid copolymer and / or their dietary and nutraceutically acceptable salts of the same and / or hydrates of the active substance that provide a timed release formulation of the active substance.
Owner:OSMOPHARM USA

Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors

Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and / or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and / or an antibody against UCP and / or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.
Owner:UNIV OF COLORADO THE REGENTS OF

Systems and methods for treating human inflammatory and proliferative diseases and wounds, with UCP and/or FAS antibody or other inhibitor, optionally with a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor

Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and / or Fas antibody or other inhibitor, or combination thereof, and a therapeutically acceptable amount of a fatty acid metabolism inhibitor and / or a therapeutically acceptable amount of a glucose metabolism inhibitor, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an antibody against UCP and / or Fas antigen with an oxirane carboxylic acid, represented by etomoxir, and / or with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.
Owner:UNIV OF COLORADO THE REGENTS OF

Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors

The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2) glycolytic inhibitors and / or UCP and / or Fas inhibitors or antibodies. More particularly, the invention combines an oxirane carboxylic acid compound, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and / or an antibody against UCP and / or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers (i.e., cancers resistant to conventional cancer drug therapies).
Owner:UNIV OF COLORADO THE REGENTS OF

Pet food compositions

Disclosed herein are pet food compositions. In one embodiment, pet food compositions which are described comprise a component selected from 2-deoxy-D-glucose; 5-thio-D-glucose; 3-O-methylglucose; 1,5-anhydro-D-glucitol; 2,5-anhydro-D-mannitol; mannoheptulose; and mixtures thereof. In yet another embodiment, pet food compositions which are described comprise an extract of plant matter selected from avocado, alfalfa, fig, primrose, and mixtures thereof. The pet food compositions may be prepared by any of a variety of processes including, but not limited to, optional processes described herein.
Owner:THE PROCTER & GAMBLE COMPANY +1

Pharmaceutical composition having activity of anticancer

InactiveUS20140235558A1Improve anti-cancer effectDoses necessary for the therapy of cancer can be decreasedBiocideCarbohydrate active ingredientsTime lagBULK ACTIVE INGREDIENT
Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and a glycolysis inhibitor, particularly, 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.
Owner:HANALL PHARMA CO LTD

Anti-cancer pharmaceutical composition

InactiveUS20140235559A1Inhibitory activityDecrease blood lactic acid levelBiocideMetabolism disorderTime lagCancer cell
Disclosed is an anticancer pharmaceutical composition comprising phenformin or a pharmaceutically acceptable salt thereof, and 2-deoxy-D-glucose as active ingredients. These ingredients act in synergy with each other, thus exhibiting more potent inhibitory activity against the growth of cancer cells, compared to individual ingredients. Also, the synergistic anticancer activity allows the individual drugs to be used in lower amounts, which leads to a reduction in the occurrence of adverse effects. In addition, the time-lag release or administration of the ingredients decreases blood lactic acid levels to significantly mitigate the adverse effect of lactic acidosis, as well as exerting high anticancer effects. Particularly, the pharmaceutical composition can be formulated to dosage forms effective for therapy, increasing the drug compliance of the subject.
Owner:HANALL PHARMA CO LTD

Pet food compositions

Disclosed herein are pet food compositions. In one embodiment, pet food compositions which are described comprise a component selected from 2-deoxy-D-glucose; 5-thio-D-glucose; 3-O-methylglucose; 1,5-anhydro-D-glucitol; 2,5-anhydro-D-mannitol; mannoheptulose; and mixtures thereof. In yet another embodiment, pet food compositions which are described comprise an extract of plant matter selected from avocado, alfalfa, fig, primrose, and mixtures thereof. The pet food compositions may be prepared by any of a variety of processes including, but not limited to, optional processes described herein.
Owner:THE PROCTER & GAMBLE COMPANY +1

Methods and products for treating proliferative diseases

Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and / or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers.
Owner:UNIV OF COLORADO THE REGENTS OF

Combination methods of treating cancer

The present invention relates to compositions and methods for treating cancer, by administering a combination comprising a jasmonate derivative (e.g., methyl jasmonate or a compound of any of formulae I through VII or any of the jasmonate derivatives exemplified by such formulae) and at least one other agent selected from a chemotherapeutic agent (e.g., a nitroso-urea, a platinum compound, a taxane derivative, an antitumor antibiotic) and an inhibitor of glycolysis (e.g., 2-deoxy-D-glucose). The jasmonate derivative and the at least one other agent together provide a therapeutic effect, which is preferably synergistic (cooperative).
Owner:SEPAL PHARMA SA +1

Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors

Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and / or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and / or an antibody against UCP and / or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.
Owner:UNIV OF COLORADO THE REGENTS OF

99mtc marked glucose derivative and preparation method and application thereof

The invention provides a tumoraffin 99mTc marked glucosamine derivative (CBADG) and a preparation method and an application thereof. The preparation method comprises the following steps: converting amino-D-glucose into 2-(4-carboxyl-1-butylamide)-2-deoxy-D-glucose ligand (CBADG), and then marking directly with 99mTc and 99mTc(CO)3 to obtain the corresponding complex of 99mTc-CBADG and 99mTc(CO)3-CBADG. The complex of 99mTc-CBADG and 99mTc(CO)3-CBADG prepared by the invention has the advantages of high radiochemical purity, high ratio of tumor / blood and tumor / muscle, and is favorable for tumor intake and detention and the like, and the novel tumor image agent prepared by the complex is worthy to be popularized.
Owner:BEIJING NORMAL UNIVERSITY

Method for preparing nano-silver water solution by modified glucose

The invention discloses a method for preparing nano-silver water solution by modified glucose, which comprises the steps of: mixing 2-(3-carboxy-1-oxopropyl)amino-2-deoxy-D-glucose water solution with the mass percent concentration of 0.01-10% and reducing agent water solution with the mass percent concentration of 0.0001-10% with silver ammonia solution with the mass fraction of 0.01-100g / L according to the volume ratio of 1000: 1: 2-1: 1: 2, and stirring for 5-600min at the temperature of 10-90 DEG C to obtain nano-silver colloidal solution with the average particle size of 1-100nm. The method can be used for preparing the nano-silver colloidal solution by modified glucose 2-(3-carboxyl-1-oxopropyl)amino-2-deoxy-D-glucose, and the obtained nano-silver is even in particle size, good in dispersity, stable in performance and low in irritation to the human body, thus having better medical value.
Owner:SUZHOU UNIV

Method of Controlling the Proliferation of Vascular Endothelial Cells and Inhibiting Lumen Formation

[PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive / remedy for diseases with angiogenesis, a cosmetic or a functional food.[MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and / or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and / or 2-deoxy-L-ribose.
Owner:RARE SUGAR PRODN TECHN RES LAB

Ultrahigh-concentration beer brewing strain and culture medium for screening same

The invention offers a culture medium for ultrahigh-concentration beer brewing strains, a method for screening the strains by using the culture medium, the strains screened by the method and a method for brewing beer with the ultrahigh-concentration beer brewing strains. The culture medium for screening the strain contains components 2-Deoxy-D-glucose. The screening method comprises the steps of acclimatization, cultivation, continuous separation, screening and process evaluation. The strains which are suitable for 20 DEG P ultrahigh-concentration wort and have the abilities of resisting 2-Deoxy-D-glucose and alcohol and deoxidizing diacetyl can be screened. By using the strains and method provided by the invention, the utilization rate of equipment can be greatly improved, and the production cost can be reduced. Compared with the beer fermented at normal concentration, the beer produced in the invention has better flavour and better taste.
Owner:CHINA NAT RES INST OF FOOD & FERMENTATION IND CO LTD

Method for obtaining a 2-18F-fluor-2-deoxy-D-glucose (18F-FDG) - solution

The invention relates to a method for improving one or more physical / chemical characteristics, like reduced radiolysis of and the ability to autoclave, a <18>F-fluor-deoxy-glucose (<18>F-FDG)-solution, which method comprises the steps of a) provision of a <18>F-fluor-deoxy-glucose (<18>F-FDG)-solution, and b) addition of at least one buffer based on a weak acid to the <18>F-fluor-deoxy-glucose (<18>F-FDG)-solution. The invention also relates to a method for preparing a sterile <18>F-fluor-deoxy-glucose (<18>F-FDG)-solution by autoclaving said <18>F-fluor-deoxy-glucose (FDG)-solution.
Owner:MALLINCKRODT INC

Process for the synthesis of 2-deoxy-D-glucose

The present invention provides a process for the synthesis of 2-deoxy-D-glucose comprising haloalkoxylation of R-D-Glucal wherein R is selected from H and 3, 4, 6-tri-O-benzyl, to obtain alkyl 2-deoxy-2-halo-R-alpha / beta-D-gluco / mannopyranoside, converting alkyl 2-deoxy-2-halo-R-alpha / beta-D-gluco / mannopyranoside by reduction to alkyl 2-deoxy-alpha / beta-D-glucopyranoside, hydrolysing alkyl 2-deoxy-alpha / beta-D-glucopyranoside to 2-deoxy-D-glucose.
Owner:COUNCIL OF SCI & IND RES

Glucose conjugated gold nanoparticle

Composition methods and kits for diagnosing and treating tumors within a subject. The compositions disclosed comprise: a gold nanoparticle; PEG or derivatives thereof, wherein said PEG or derivatives thereof have a molecular weight of 400 to 1500 Dalton; and a 2-Deoxy-D-glucose, wherein the PEG or derivatives thereof are linked to the gold nanoparticle and to said 2-Deoxy-D-Glucose, and wherein the 2-Deoxy-D-Glucose is linked to the PEG or derivatives thereof at the 2-Carbon position of the 2-Deoxy-D-Glucose.
Owner:BAR ILAN UNIV

Therapeutic Bifunctional Compounds

The invention generally relates to systems and methods for treating inflammatory and proliferative diseases, enabling treatment of MDR tumor cells by using a bifunctional compound that inhibits both fatty acid metabolism and glycolysis. Thus, the invention links a fatty acid metabolism inhibitor to a glycolysis inhibitor. More particularly, the invention provides novel bifunctional compounds that link a moiety having the functionality of an oxirane carboxylic acid compound to a moiety having the functionality a glucose derivative. In specific embodiments, the invention provides a bifunctional compound that links a moiety having the functionality of etomoxir to a moiety having the functionality of 2-deoxy-D-glucose.
Owner:UNIV OF COLORADO THE REGENTS OF

Therapeutic composition to treat lesions caused by herpes simplex virus

The present invention is generally directed toward therapeutic compositions for treating infections caused by Herpes Simplex Virus (“HSV”). The therapeutic compositions meet a long felt need in the art of providing a treatment for lesions that result from HSV that drastically reduce the duration of a cold sore when vesicles have already appeared and a treatment that will prevent the outbreak of a lesion and formation of vesicles when applied in the prodormal stage. The therapeutic compound comprises a mixture of Acyclovir (“ACV”), Penciclovir (“PCV”), and 2-Deoxy-D-Glucose (“2-DDG”). The therapeutic compositions of the present invention include multiple formulations of the three active ingredients and may also include inactive ingredients.
Owner:G2L TOUCH

Gel material for preventing intestinal adhesion

The invention relates to a gel material for preventing intestinal adhesion, which is used for preventing peritoneal adhesion after operation. Hyaluronic acid crosslinking preparations for isolating damaged wounds can cause severe adverse reactions during application, such as abdominal pain, abdominal infection, and intestinal adhesion, and even reoperation is performed due to adverse reactions for some patients; the hyaluronic acid crosslinking preparations also have a dissociation phenomenon in the body, and the isolation effect is reduced. The gel material for preventing intestinal adhesion of the invention is a gel system formed by polyacrylamide, a hydrotalcite colloid material, iron ion crosslinked hyaluronic acid gel liquid, 2-deoxy-D-glucose (2-DG) with anti-inflammation and pain-relieving efficacy, tramadol hydrochloride, and acetaminophen. After operation, the gel material is coated directly on a wound; crosslinking effect is generated with fibrin blood clots on the wound; thus the gel material is firmly adhered to the wound; good isolation effect is reached. The medicinal components with anti-inflammation pain-relieving efficacy are directly applied to the wound; and inflammation caused by singly application of hyaluronic acid isolating substances is alleviated.
Owner:SHANDONG PROVINCIAL HOSPITAL

Clostridium acetobutylicum strain and screening method and application thereof

The invention relates to a Clostridium acetobutylicum strain capable of quickly generating butanol by fermenting xylose and starch, and a screening method and application thereof. The invention discloses Clostridium acetobutylicum, which is classified and named Clostridium acetobutylicumXY16 with the preservation and registration number of CCTCC NO:M2010011. The strain obtained by ion beam mutation and screening of a xylose plate, a 2-deoxy-D-glucose plate, a bromocresol green plate and a resazurin plate can quickly and efficiently generate the butanol by fermenting xylose and starch, has the advantages of high yield of total solvent, high butanol ratio and good repeatability, and is a good strain suitable for industrial production.
Owner:NANJING UNIV OF TECH

Method for enhancing cellobiase activity of termitomyces clypeatus using a glycosylation inhibitor

This invention provides a method for enhancing the cellobiase activity of the strain Termitimyces clypeatus using 2-deoxy-D-glucose as glycosylation inhibitor, said process comprises inoculating and growing mycelial culture of (the edible mushroom) Termitimyces clypeatus, in sterilized medium containing 0.05 to 5.0% of 2-deoxy-D-glucose in addition to 0.5 to 2.0% of cellobiose, succinate—0.5%, 2 to 3% of ammonium di hydrogen phosphate and conventional micro-nutrients at pH between 3 to 8 and incubating at temperatures between 20-35° C. under shaking in aerobic conditions, and separating the culture medium by known methods, and using the culture filtrate directly as the source of the enzyme cellobiase and also for endo-glucanase and cellobiohydrolase for use in cellulose hydrolysis.
Owner:COUNCIL OF SCI & IND RES PL

Traditional Chinese medicine composition for enhancing immunity and preparation method thereof

The invention discloses a traditional Chinese medicine composition for enhancing the immunity, which is composed of the following components in weight percentage: 5-30% of lentinus edodes extractive, 10-30% of Chinese wolfberry extractive, 10-30% of shikimic acid, 0.5-5% of 2-deoxy-D-glucose and residual amount of anhydrous dextrose. The invention further discloses a preparation method of the traditional Chinese medicine composition and an application of the traditional Chinese medicine composition to enhancing the immunity of livestock. According to the traditional Chinese medicine composition disclosed by the invention, the growth of immune organs of the livestock are obviously accelerated and the organic immunity of the livestock is enhanced; the curative effects on immunosuppression and low functions, which are caused by immunosuppressive diseases, particularly viral diseases, are obvious, and the mortality of the livestock can be obviously reduced; and secondarily, with the adoption of the traditional Chinese medicine composition disclosed by the invention, an antibody titer in the immune livestock can be obviously improved, the in vivo action time of an antibody is prolonged, the humoral immunity is enhanced and the immune effect of vaccines is enhanced; and furthermore, the source of raw materials of the composition is abundant, the production method is simple and the use is convenient.
Owner:JIANGSU NANJING AGRI UNIV ANIMAL PHARM CO LTD

Improved FDG synthesis method

The invention relates to an improved FDG (2-fluoro-2-deoxy-D-glucose) synthesis method. The method comprises the following steps: 1, leaching: eluting <18>F<-> with a potash / K2.2.2 / acetonitrile mixed solution; 2, drying: adding an HPLC acetonitrile solution, uniformly mixing, and drying at 121-123DEG C; 3, a fluorination reaction: adding a mannose triflate / anhydrous acetonitrile solution, and heating under a closed condition to carry out a fluorination reaction; 4, hydrolysis: adding an NaOH solution after the fluorination reaction to carry out hydrolysis; and 5, purifying transfer: adding an HCl solution and disinfected injection water for purifying transfer, wherein a volume ratio of the potash / K2.2.2 / acetonitrile mixed solution in step 1 to the HPLC acetonitrile solution in step 2 is 1.5:2, and a volume ratio of the HCl solution in step 5 and the disinfected injection water in the step 5 is 1.5:11. Compared with the prior art, the method provided by the invention has the advantages of simple operation, high synthesis efficiency, high stability and the like.
Owner:SHANGHAI ATOM KEXING PHARMA
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