94results about How to "Use of composition" patented technology

A curable composition comprising (A) an organopolysiloxane having functional groups capable of condensation reaction at both molecular terminals thereof and (B-1) a hydrophobic silica and a hydrophilic silica. A curable composition comprising (A) an organopolysiloxane having functional groups capable of condensation reaction at both molecular terminals thereof and (B-2) a hydrophobic silica, wherein the hydrophobic silica (B-2) is thermally treated together with the organopolysiloxane (A). The organopolysiloxane (A) is preferably represented by the formula: W3-a(R1a)Si(R2)O-(Si(R2)O)n-Si(R1a)W3-a [alpha] (wherein W represents a hydroxyl group or a hydrolyzable group; each of R1 and R independently represents an unsubstituted or substituted monovalent hydrocarbon group having 1 to 12 carbon atoms, provided that the hydrocarbon groups R1 as well as the hydrocarbon groups R may be identical with or different from each other; n is an integer of 5 or greater; and a is 0, 1 or 2). When, in the formula [alpha], W represents a hydroxyl group and a is 2, the curable composition preferably comprises, in addition to the components (A) and either (B-1) or (B-2), (C) an organosilane represented by the formula: R1bSiX4-b [I] (wherein R1 represents an unsubstituted or substituted monovalent hydrocarbon group having 1 to 8 carbon atoms; X represents a hydrolyzable group; and b is 0 or 1), or a partial hydrolyzate of the organosilane. Thus, a curable composition, especially a curable paint composition and an antifouling paint composition, and an antifouling coating film of the following characteristics can be provided. The curable composition, in particular when used as a coating material or a paint, is excellent in sprayability and enables forming a thick coating film by one-time application. The curable composition enables shortening the operating period for coating, and a coating film of uniform thickness can be obtained by the application thereof. The obtained coating film is excellent in film strength and film hardness and, when used for antifouling purposes, exerts excellent antifouling capability for a prolonged period of time. Further, the curable composition ensures excellent storage stability before application thereof.

The present invention relates to pharmaceutical compositions comprising a sulfonamide-including compound in combination with an angiogenesis inhibitor.

The present invention relates to a composition, in particular a cosmetic composition, to care for and / or make up the skin and / or integuments and / or the lips, which can be in the form of a cast product or a gel, comprising at least one non-volatile hydrocarbon-based oil with a molecular mass ranging from 230 to 420 g / Mol, a non-volatile silicone compound which is soluble or dispersible in the non-volatile hydrocarbon-based oil, and an inert particulate phase containing at least one chemically inert filler. The invention also relates to a care or make-up process for the skin, integuments and the lips using such a composition. More especially, the invention is a solid make-up product for the lips, having transfer-resistance and migration-resistance properties while at the same time being glossy and comfortable to wear over time.

The present invention is directed to a composition and method for enhancing the appearance of skin or tissue. The invention is preferably a combination of elastin-derived peptides and steroidal compounds useful in the treatment of problems associated with deficient elastin or conditions that would benefit from increased elastin.

The present invention relates to pneumococcal genes, portions thereof, expression products therefrom and uses of such genes, portions and products; especially to genes of Streptococcus pneumoniae, e.g., the gene encoding pneumococcal surface protein A (PspA), i.e., the pspA gene, the gene encoding pneumococcal surface protein A-like proteins, such as pspA-like genes, e.g., the gene encoding pneumococcal surface protein C (PspC), i.e., the pspC gene, portions of such genes, expression products therefrom, and the uses of such genes, portions thereof and expression products therefrom.

Disclosed are a novel tactic acid bacterium, Lactobacillus sakei Probio-65, and the use thereof. The L. sakei Probio-65 strain has acid tolerance, bile acid tolerance and antibiotic resistance, inhibits the growth of harmful pathogenic microorganisms in the body and the intestine of animals, and has immunuenhancing activity. In particular, the novel strain inhibits the growth of Staphylocccus aureus, which is known to be a factor aggravating atopic dermatitis. Thus, the novel strain is useful for preventing or treating atopic dermatitis and allergy-related disorders. Also, the novel strain stabilizes intestinal microflors by inhibiting the abnormal proliferation of harmful microorganisms in the intestine. The L. sakei Probio-65 strain or a culture thereof is useful in pharmaceutical, feed, food, and cosmetic compositions.

A composition is disclosed for a mixture to be used in conjunction with water for preparing a slurry that hydrates to form a high strength flooring compound. The mixture includes from about 50% to about 98% by weight calcium sulfate hemihydrate. A three repeating unit polycarboxylate dispersant is included in the mixture in amounts from about 0.2% to about 10% by weight. The repeating units include a polyether repeating unit, an acrylic acid-type repeating unit and a maleic acid-type repeating unit. A modifier that enhances the efficacy of the dispersant is also a component of the mixture. When combined with recommended amounts of water, a slurry is formed that is useful as a flooring composition.

Methods and compositions for removing a contaminant from its environment. The method includes forming a magnetic composition comprising the contaminant and an amphiphilic substance, and applying a magnetic field to the magnetic composition so as to separate the magnetic composition from the environment. One composition includes a micelle array confined in a magnetic mesoporous framework. Another composition is formed by adhering an amphiphilic material comprising functional surface groups to a contaminant, then interacting a magnetic material with the functional surface groups of the amphiphilic material. In various versions, the contaminant can be a hydrophobic organic compound, or a fullerene-related nanoparticle. The methods can also be used to purify hydrophobic organic compounds or fullerene-related nanoparticles.

A sulfonium salt is provided that has a cation represented by Formula (II)(R1′ to R13′ in Formula (II) independently denote a hydrogen atom or a substituent, and may be bonded to each other to form a ring, provided that at least one of R1′ to R8′ denotes a halogen atom or a haloalkyl group). There are also provided a curable composition that includes the sulfonium salt, and an ink composition that includes the curabie composition. Furthermore, there are also provided an inkjet recording method employing the ink composition, and a process for producing a lithographic printing plate, the process including discharging the ink composition onto a hydrophilic support. A printed material and a lithographic printing plate thus obtained are also included in the present invention.

The present invention provides a mitochondrial activator containing pyrroloquinoline quinone, preferably pyrroloquinoline quinone and coenzyme Q (particularly reduced coenzyme Q) as active ingredients. In addition, the present invention provides a mitochondrial activator containing citric acid, preferably citric acid and coenzyme Q (particularly reduced coenzyme Q), as active ingredients. Since pyrroloquinoline quinone or citric acid exhibits a synergistic mitochondria activating effect with coenzyme Q (particularly reduced coenzyme Q), a high effect can be obtained even at a low dose. According to the present invention, therefore, a safer and practical mitochondrial activator is provided. The present invention further provides an agent for the prophylaxis or treatment of a disease caused by mitochondrial dysfunction.

Flavonoids, especially luteolin, are shown to be effective against insulin dependent (Type I) and insulin independent (Type II) diabetes mellitus. It is demonstrated that luteolin works in mammals by binding and blocking the Kv1.3 potassium channel of T-cell and Beta cells. Antidiabetic and anti-autoimmune compounds can be selected by measuring their ability to bind to and block the Kv1.3 channel.

The present invention pertains to a siliconized polyester resin that has a sufficiently high Tg that the siliconized polyester is a solid at room temperature. The silicone polyester preferably has a Tg of 30° C. or greater. The silicone polyester can be produced as a particulate and remain stable at room temperature. The particulate silicone polyester is suitable for use in coating compositions, including powder coating compositions. The coating can be clear or pigmented, and thus optionally can include pigment. The coating composition also includes a crosslinker. The coating composition can be ground into a powder. The powder is stable at room temperature. The powder is then capable of being coated on a suitable substrate and then baked to form a coated metal object.

An electrolyte composition and a solid polymer electrolyte for electrical double-layer capacitors are endowed with high ionic conductivity. The invention is also directed at a polar electrode composition and a polar electrode having excellent binder capabilities which are able to strongly bond a high surface area material such as activated carbon and an electrically conductive material to a current collector, and which also have shape stability. A high-performance electrical double-layer capacitor arrived at using the above compositions and components is additionally disclosed.

De-polluting, self-cleaning coating compositions are disclosed which comprise an extender that comprises a mixture of calcium carbonate and one or more alternate extenders. The coatings of the invention exhibit improved durability and opacity without affecting the photocatalytic removal of NOx compounds.

The present invention relates to a fusion protein composed of the extracellular domain of PD-L1 and a modified immunoglobulin Fc region. The extracellular domain of PD-L1 and a fragment thereof have excellent immunomodulatory activity, and can be used as an immunomodulatory agent if a modified immunoglobulin Fc region is coupled thereto. Accordingly, the PD-L1 fusion protein according to the present invention demonstrated its excellent effect in disease models of inflammatory bowel disease, colitis, psoriasis, asthma and arthritis, and thus can be very effectively used for the treatment of such diseases.

Disclosed are a novel tactic acid bacterium, Lactobacillus sakei Probio-65, and the use thereof. The L. sakei Probio-65 strain has acid tolerance, bile acid tolerance and antibiotic resistance, inhibits the growth of harmful pathogenic microorganisms in the body and the intestine of animals, and has immunuenhancing activity. In particular, the novel strain inhibits the growth of Staphylocccus aureus, which is known to be a factor aggravating atopic dermatitis. Thus, the novel strain is useful for preventing or treating atopic dermatitis and allergy-related disorders. Also, the novel strain stabilizes intestinal microflors by inhibiting the abnormal proliferation of harmful microorganisms in the intestine. The L. sakei Probio-65 strain or a culture thereof is useful in pharmaceutical, feed, food, and cosmetic compositions.

[Problem to be Solved]The present invention provides a compound promoting osteogenesis. [Solution]The present invention provides a compound having the following general formula (I) wherein R1 is H or alkyl, R2 is RaS—, RaO—, RaNH—, Ra(Rb)N— or cyclic amino, and Ra and Rb are alkyl which may be substituted, cycloalkyl which may be substituted, or the like, or a pharmacologically acceptable salt thereof.

The invention relates to methods of making films having active ingredients. A film that is substantially free of active ingredient is introduced into a medium comprising an active ingredient. At least a portion of the active ingredient is transferred from the medium to the film. The films can be used in a variety of applications, including oral care, personal care, cleansing and / or home care compositions.

Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

The present invention relates to novel heterocyclic compounds which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

The present invention relates to novel heterocyclic compounds of formula Iwherein the variables are as defined in the claims or the description,which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3β, and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3β activity using the compounds.

There is provided a water-soluble flux composition for soldering which is excellent particularly in heat resistance and flux residues after soldering of which can be easily removed by washing with water or warm water. The flux composition for soldering contains a compound of formula (1): wherein R1, R2, R3, Rd4, R5 and R6 independently of one another are a hydrocarbon group or hydrogen atom, and A1, A2 and A3 independently of one another are hydroxy group or an organic group of formula (2): and at least one of A1, A2 and A3 is an organic group of formula (2).

De-polluting, self-cleaning coating compositions are disclosed which comprise an extender that comprises a mixture of calcium carbonate and one or more alternate extenders. The coatings of the invention exhibit improved durability and opacity without affecting the photocatalytic removal of NOx compounds.

A transitional treatment composition and methods of treating coal refuse are provided. The transitional treatment composition comprises an anionic acrylate-acrylamide copolymer having from about 30 mole percent to about 50 mole percent (meth)acrylate, from about 50 mole percent to about 70 mole percent (meth)acrylamide, and a reduced specific viscosity of from about 18 dL / g to about 30 dL / g. The transitional treatment composition can be made down in an aqueous liquid.

The predominately (R)-(+) isomer of 1-alkyn-3-ol compounds of the formula: where R1 is a saturated aliphatic hydrocarbon group containing from 1 to about 12 carbon atoms, and R2 is hydrogen, are most effective attractants for mosquitoes.

A transitional treatment composition and methods of treating coal refuse are provided. The transitional treatment composition comprises an anionic acrylate-acrylamide copolymer having from about 30 mole percent to about 50 mole percent (meth)acrylate, from about 50 mole percent to about 70 mole percent (meth)acrylamide, and a reduced specific viscosity of from about 18 dL / g to about 30 dL / g. The transitional treatment composition can be made down in an aqueous liquid.

Described herein are topical compositions containing an effective amount of propylene glycol, as a sole active ingredient or a principal active ingredient, and a pharmaceutically acceptable medium. Also described herein are methods of promoting the growth of or the regeneration of a tissue such as nail, hair, gum and skin in humans by topically administering the topical compositions to a human in need thereof.