39results about How to "The synthesis process is simple and green" patented technology

The invention relates to an iridium complex containing a carboryl benzimidazole structure and a preparation method and application thereof. The preparation method of the iridium complex comprises the following steps: 1) adding the n-BuLi solution to the carborane solution, and then React at room temperature for 30-60min; 2) Add bromobenzimidazole and react at room temperature for 6-8h; 3) Add [Cp*IrCl 2 ] 2 , and react at room temperature for 3‑5h, after post-treatment to obtain the iridium complex; the iridium complex is used to catalyze the asymmetric reduction of aryl ketones to prepare chiral alcohols. Compared with prior art, the present invention uses binuclear iridium compound [Cp*IrCl 2 ] 2 As a raw material, it is reacted with n-BuLi and ortho-carboryl benzimidazole to obtain a trivalent iridium complex containing an ortho-carboryl benzimidazole structure. The iridium complex has stable physical and chemical properties and Thermal stability, and the synthesis process is simple and green. It catalyzes the asymmetric reduction reaction of aryl ketones to synthesize chiral alcohols under mild conditions. It has excellent catalytic activity, enantioselectivity and high yield.

The invention relates to a ruthenium complex containing a carboranyl benzimidazole structure as well as a preparation method and application of the ruthenium complex. The preparation method of the ruthenium complex comprises the following steps: 1) adding a n-BuLi solution into a carborane solution, and performing a reaction at room temperature for 30-60 min; 2) adding bromobenzimidazole, and performing a reaction at room temperature for 6-8 h; and 3) adding [(p-cymene)RuCl2]2, performing a reaction at room temperature for 3-5 h, and performing post treatment to obtain the ruthenium complex. The ruthenium complex is used to catalyze self-oxidative coupling of primary amines to prepare imine compounds. Compared with the prior art, the method provided by the invention uses the dinuclear ruthenium compound [(p-cymene)RuCl2]2 as a raw material, and the [(p-cymene)RuCl2]2 is reacted with the n-BuLi and o-carbonboryl benzimidazole to obtain the bivalent half-sandwich ruthenium complex containing the o-carbonboryl benzimidazole structure; and the ruthenium complex provided by the invention has stable physicochemical properties and thermal stability, is still stable at high temperature of300 DEG C, has a simple and green synthetic process, and exhibits excellent activity in the reaction of catalyzing the self-oxidative coupling of primary amines to prepare the imine compounds.

The invention relates to a binuclear rhodium complex containing an ortho-carborane structure and its preparation and application. The preparation method of the rhodium complex comprises the following steps: 1) adding n-BuLi solution to the ortho-carborane solution, Then react at room temperature for 30-60min; 2) add selenium, and react at room temperature for 1-2h; 3) add [Cp*RhCl 2 ] 2 , and react at room temperature for 3‑6h, and obtain the rhodium complex after post-treatment; the rhodium complex is used to catalyze the N-methylation reaction of arylamine to prepare arylamine N-methylated derivatives. Compared with the prior art, the preparation method of the binuclear semi-sandwich rhodium complex containing the ortho-carborane structure in the present invention is simple and green, has excellent selectivity and higher yield, and the prepared rhodium complex is stable at room temperature It has high catalytic activity, can be used to catalyze the N-methylation reaction of arylamines to prepare N-methylated derivatives of arylamines, has high catalytic reaction yield, and has wide industrial application prospects.

The invention provides a method for preparing enamine compounds by catalyzing the hydroamination reaction of cyclohexylacetylene, which is characterized in that, under the catalysis of the catalyst, cyclohexylacetylene and secondary amine undergo hydroamination reaction in a solvent , to obtain enamine compounds; the molecular formula of the catalyst is [R 1 R 2 C(C 5 h 4 N) 2 ] Pd=NPh, wherein, R 1 and R 2 independently selected from H, CH 3 and Ph, the solvent is an aromatic hydrocarbon, the reaction temperature is 60-100°C, and the reaction time is 6-12h. The invention has mild reaction conditions, high catalytic efficiency, high atom economy, low cost, easy separation of products, no large amount of waste residue, and is suitable for industrial production.

The invention provides a large-steric-hindrance trivalent rhodium imide complex containing a rhodium-nitrogen dual-key structure. The large-steric-hindrance trivalent rhodium imide complex is characterized by including the following structure shown in the description. A synthesis technology is simple and green, and has excellent selectivity and a high yield. The large-steric-hindrance trivalent rhodium imide complex has the features of stable physical and chemical properties and thermal stability, and has excellent activity and regional selectivity in an anti-Markovnikov hydroamination reaction of olefins.

The invention relates to the application of a palladium complex in fatty carbamylation reaction, using N,N-coordinated palladium complex containing meta-carborane ligand as catalyst, and N,N-dimethyl Formamide is used as a formylating reagent and solvent to catalyze the formylation reaction of fatty amines to prepare fatty amine formamide compounds. Compared with the prior art, in the present invention, the divalent palladium complex containing meta-carborane ligands coordinated by N,N has higher catalytic activity under mild conditions, and can catalyze the formylation reaction of aliphatic amines , DMF is used as a formylating reagent and a solvent at the same time, it is cheap, low-toxic and easy to separate, and the yield is high (88‑96%).