The invention relates to a process for printing and dyeing artificial leather by using mangosteen bark juice, comprising the following steps: a, preparing a mangosteen bark dye: taking mangosteen bark, performing superfine grinding to obtain the mangosteen bark juice, then adding ethyl alcohol with the concentration of 80 percent, dipping for 12-24h, filtering with a sieve of 80-100 meshes, and collecting filter liquor, wherein a ratio of the volume of the ethyl alcohol to the mass of the mangosteen bark is (5 to 10) : 1; dipping filter residues by adopting the same ethyl alcohol for 12-24h, filtering with a sieve of 80-100 meshes, and collecting filter liquor; combining filter liquor obtained by two times of collecting, concentrating, and vacuum-drying to obtain the solid, i.e., the mangosteen bark dye; b, preparing a dye; c, treating the artificial leather; d, dyeing; e, heating for evaporation; f, performing afterfinish. The printing and dyeing process can improve the attachment of the vegetable dye on leather, so that the printed and dyed leather is not easy to fade.