35results about How to "Prevent negative consequence" patented technology

A medical system is disclosed that has three basic components; a retractable sheet, a first balloon that has a centrally arranged hollow, and a collapsible / expandable support structure at the hollow. The first balloon is for instance mounted / molded onto the exterior surface of the support structure. The aggregate of support structure and the first balloon is positioned, and once the sheet has been retracted from the first balloon, the first balloon is inflated. The support structure may be self-expandable or expandable by an expansion unit, such as a further balloon arranged at its inside. The lumen of the support structure is chosen to be smaller than that of a main lumen. The outside diameter of the inflated first balloon is chosen to be larger than the interior diameter of the main lumen. This procedure may be done using standard Seldinger technique and fluoroscopy. This makes the system user friendly and increases patient safety, as a well established clinical method may be used with some modifications according to the invention.

The invention relates to the production of paraxylene by an alkylation process that also produces oxygenates. The process is controlled to utilize recycle to minimize said oxygenates.

A method of screening peptides which bind to at least one PDZ domain and comprise a cell-membrane transduction domain for use in treating traumatic injury to the brain or spinal cord by deforming neurons on a flexible substrate with sublethal stretch, then inflicting a secondary injury, and determining survival of the stretched neurons in the absence or presence of the peptide which is being screened.

A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron the method comprising administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor neuronal protein. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity and ischemic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95 / NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults and dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia. The treatment was effective when applied either before, or one hour after, the onset of excitotoxicity in vitro and cerebral ischemia in vivo. This approach prevents negative consequences associated with blocking NMDAR activity and constitutes practical therapy for stroke.

A method for setting a combustion in a combustion engine, particularly in a diesel engine, having the following steps of generating a manipulated variable, particularly a point of injection (PI), as a function of a combustion feature (MFB50%), the combustion feature (MFB50%) representing a condition in cylinder, especially a pressure characteristic in the cylinder, and setting the combustion in cylinders of the combustion engine with the aid of the manipulated variable, the manipulated variable further being generated as a function of a correction value (CV), which is determined as a function of combustion information (dQmax) that provides an indication about the quality of the combustion.

The invention relates to the production of paraxylene by an alkylation process that also produces oxygenates. The process is controlled to utilize recycle to minimize said oxygenates.

A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor-neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARS) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95 / NMDAR interaction complex. This treatment attenuated downstream NMDAR signaling without blocking NMDAR activity, protected cultured cortical neurons from excitotoxic insults, dramatically reduced cerebral infarction volume in rats subjected to transient focal cerebral ischemia, and traumatic brain injury (TBI) in rats.

The process concerns ethylbenzene conversion and xylene isomerization with a catalyst pretreated by sulfiding.

For the prevention of contamination of a vial with traces of medicinal fluids, for example cytostatics and antibiotics, which may be spilt on the outside of the vial while filling, the vial is provided with a tight-fitting protective envelope, preferably made of a transparent synthetic material, as a last step in the production process. Because of this, a possible contamination which remains on the outside of the vial is encapsulated between the vial and the envelope. Hereby, a user is no longer exposed to toxic substances, because the user will not touch the vial itself, but will touch the envelope. An additional advantage of the provision of the envelope is that if breaking of the vial occurs, the envelope will keep the pieces of broken glass together and will possibly prevent the medicinal fluid from leaking away.

A medical system is disclosed that has three basic components; a retractable sheet, a first balloon that has a centrally arranged hollow, and a collapsible / expandable support structure at the hollow. The first balloon is for instance mounted / molded onto the exterior surface of the support structure. The aggregate of support structure and the first balloon is positioned, and once the sheet has been retracted from the first balloon, the first balloon is inflated. The support structure may be self-expandable or expandable by an expansion unit, such as a further balloon arranged at its inside. The lumen of the support structure is chosen to be smaller than that of a main lumen. The outside diameter of the inflated first balloon is chosen to be larger than the interior diameter of the main lumen.

The invention relates to vaccines used in the eradication or control of pestivirus infections, particularly those used in pigs or ruminants. The invention provides nucleic acid, pestivirus-like particles and a pestivirus vaccine, comprising the nucleic acid or particles, which is capable of eliciting a proper immune response without having the ability to spread throughout the vaccinated animal, thereby avoiding the negative consequences of viral spread. Preferably, the immune response allows for serological discrimination between vaccinated animals and wild-type pestivirus infected animals.

A method is described for controlling a compression-ignition internal combustion engine, including predefining a setpoint combustion point for a compression-ignition internal combustion engine, predefining a calculation model for calculating a probable deviation of a future cycle of the engine from the predefined setpoint combustion point while taking an ascertained actual combustion point of a completed cycle engine into consideration, predefining a mean deviation for the engine, operating the engine for a first cycle and ascertaining an actual combustion point of the first cycle, calculating a probable deviation of a second cycle, which occurs after the first cycle, of the engine from the predefined setpoint combustion point, comparing the calculated probable deviation of the second cycle to the predefined mean deviation, and ascertaining at least one operating variable for operating the engine at least during the second cycle as a function of the comparison. Also described is a related method.

A cell culture substrate for cultivating adherent cells, including:a substrate (S),a polymer (P) comprising amino groups, which is bonded to the substrate, anda saccharide (Z) having at least two monosaccharide units for attaching the adherent cells,wherein the saccharide (Z) is covalently bonded to the polymer (P) via the amino groups.Such a cell culture substrate is suitable for cultivating adherent cells and allows the cells to be detached from the cell culture substrate in a gentle manner by adding a saccharide.

A tablet press comprises a gate that defines a first switching position that feeds tablets into a first tablet outlet and at least a second switching position that feeds tablets into at least one second tablet outlet. The table press further comprises a control apparatus and a drive apparatus. The drive apparatus is configured to be actuated by the control apparatus to move the gate from a home position defined as one of the first switching position and the at least a second switching position into a target position defined as a switching position that is not the home position. The gate is moved from the home switching position at a speed of movement toward the target position such that the speed of movement of the gate is reduced before the target position is reached.

A method of detecting a network hang and restoring an application that communicates on a connection giving rise to the network hang. A user experience may be improved by providing the user with an option to restore the hung application without losing unsaved data or state information. The network hang may be detected when the user tries to terminate the application. The method may include determining whether the network hang is recoverable, which may involve diagnosing a type of the hang. If recoverable, a network connection reset mechanism may be triggered by instructing a network stack of the computer to terminate the network connection.

The invention relates to nucleic acid, which codes for an autoactivated resistance protein for creating a resistance to pathogens in plants, characterized in that the nucleic acid has a limited portion of an NBS-LRR resistance gene, which extends from the 5′-end of the coded region of the NBS-LRR resistance downstream to the beginning of the NBS domain of the NBS-LRR resistance gene, the NBS-LRR resistance gene not being a TIR-NBS-LRR resistance gene.

A method to control a road vehicle provided with a clutch, which connects an internal combustion engine to drive wheels and is arranged upstream of a servo-assisted transmission; the control method comprises the steps of: checking whether the tyres of the drive wheels are close to a grip limit; and opening the clutch so that the clutch transmits a torque to the drive wheels with a slip of the clutch that is constant and other than zero when the tyres of the drive wheels are close to the grip limit.