45results about How to "Optimization of response" patented technology

The present invention teaches a method and apparatus for physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, depression, epilepsy, and diabetes. This includes chronically implanted neural and neuromuscular modulators, used to modulate the afferent neurons of the sympathetic nervous system to induce satiety. Furthermore, this includes neuromuscular stimulation of the stomach to effect baseline and intermittent smooth muscle contraction to increase gastric intraluminal pressure, which induces satiety, and stimulate sympathetic afferent fibers, including those in the sympathetic trunk, splanchnic nerves, and greater curvature of the stomach, to augment the perception of satiety.

Vehicle telematics system including an occupant sensing system arranged to determine one or more properties or characteristics of occupancy of the vehicle, a crash sensor system for determining when the vehicle experiences a crash and a communications device arranged to enable a communications channel to be established between the vehicle and a remote facility after the vehicle is determined to have experienced a crash. Information determined by the occupant sensing system is transmitted via the communications channel to the remote facility, even in the absence of initiation of the communications channel by the occupant. The occupant sensing system may include an image-obtaining sensor for obtaining images of the passenger compartment of the vehicle, a motion sensor, receivers arranged to receive waves, energy or radiation from seating locations in the passenger compartment, heartbeat sensors, weight sensors associated with seats in the vehicle and / or chemical sensors.

The present invention teaches a method and apparatus for user control and operation of physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity, metabolic disease, and other conditions. This includes programming of neuromodulatory signal for the modulation of autonomic neural and neuromuscular modulators, used to modulate tissues, including the afferent neurons of the sympathetic nervous system to induce satiety and efferent neurons to modulate metabolism. The apparatus and methods include a conformal neuromodulator array which facilitates minimally invasive placement of neuromodulators in communication with target tissues.

A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

The present invention teaches methods and apparatus for user control and operation of physiological modulation, including neural and gastrointestinal modulation, for the purposes of treating several disorders, including obesity. This includes programming of neuromodulatory signal for the modulation of autonomic neural and neuromuscular modulators, used to modulate tissues, including the afferent neurons of the sympathetic nervous system to induce satiety and efferent neurons to modulate metabolism.

Method for controlling deployment of an airbag into a passenger compartment of a vehicle including detecting a position of an occupant whose forward-facing surface will be the surface which interacts with the airbag upon its deployment, determining a desired amount of gas within the airbag during inflation of the airbag based at least in part on the detected position of the occupant, and adjusting the amount of gas within the airbag during inflation of the airbag to provide the airbag with the desired amount of gas during its inflation. Adjustment of the amount of gas within the airbag may entail varying the amount of gas being directed into the airbag based on the morphology of the occupant (inflow control) and / or controlling the outflow of gas from the airbag based on the morphology of the occupant (outflow control).

Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

A therapeutic device and method for use thereof for treatment of blood flow disorders is disclosed. In one embodiment, a first line emergency response system for treatment of acute thrombotic and / or vasospastic vascular obstructions via the noninvasive application of low frequency vibration with at least one, and preferably a plurality of randomly administered vibratory waveform characteristics (herein after “Randomic Vibration”) is detailed. The disclosed apparatus and methods are based on the intuition that transcutaneously imparted low frequency randomic vibration can provide enhanced clot disruption and mixing of clot disruptive agents to acutely thrombosed vessels, due to the addition of mechanical chaos via non-regular, multi-vectored convection currents. In a preferred embodiment, the disclosed apparatus and methods preferably utilize randomic vibration as an adjunct to systemically administered drug therapy, most preferably intravenously administered thrombolytic drug therapy.

Method for controlling deployment of an airbag into a passenger compartment of a vehicle including detecting a position of an occupant whose forward-facing surface will be the surface which interacts with the airbag upon its deployment, determining a desired amount of gas within the airbag during inflation of the airbag based at least in part on the detected position of the occupant, and adjusting the amount of gas within the airbag during inflation of the airbag to provide the airbag with the desired amount of gas during its inflation. Adjustment of the amount of gas within the airbag may entail varying the amount of gas being directed into the airbag based on the morphology of the occupant (inflow control) and / or controlling the outflow of gas from the airbag based on the morphology of the occupant (outflow control).

A detector system measures radioactive material. A fluid path receives at least one aliquot of radiopharmaceutical. The fluid path locates the aliquot within a positioner formed with a concave configuration. A detector is located at an axial distance from the concave surface and determines the level of radioactivity of the aliquot. Alternatively, the fluid path may be less concave and a variable attenuator may be placed between the fluid path and detector. The variable attenuator may have a concavity that is based on the concavity of the fluid path so that the detector's ability to read the radioactivity is optimized. A method for forming an aliquot of radiopharmaceutical in a concave fluid passage. Positioning a detector located a distance from the concave surface to optimize reading spectral energy of the aliquot and activity is determining activity regardless of the position of the aliquot in the passage.

A vehicle including a system for obtaining information about occupants of the vehicle including a rear-view mirror including a mirror part and a support for mounting the mirror part to the vehicle (such as to a windshield of the vehicle), a wave-receiving system arranged on the mirror for receiving waves from spaces above seats of the vehicle in which occupants would normally be situated and a processor coupled to the wave-receiving system and arranged to obtain information about the occupants based on the waves received by the wave-receiving system. The wave-receiving system may include an infrared receiver, a transmitter / receiver capable of transmitting and receiving waves, an ultrasonic wave receiver and / or an array for displaying infrared light reflected from or generated by the occupants. Based on the waves received by the wave-receiving system, the processor may identify or ascertain the identity of the occupants, determine the position or movement of the occupants and / or determine the distance between the wave-receiving system and the occupants. The processor may embody a pattern recognition system for obtaining information about the occupants based on training designed to create an algorithm capable of processing data on the waves received by the wave-receiving system into information about the occupants.

A system and method in accordance with an embodiment reduces the cross-axis sensitivity of a gyroscope. This is achieved by building a gyroscope using a mechanical transducer that comprises a spring system that is less sensitive to fabrication imperfection and optimized to minimize the response to the rotations other than the intended input rotation axis. The longitudinal axes of the first and second flexible elements are parallel to each other and parallel to the first direction

A digital automatic gain control (AGC) circuit for use in a radio frequency (RF) receiver. The AGC circuit comprises: 1) a first shifter for receiving an in-phase signal as a first series of X-bit samples and left-shifting each X-bit sample by a number of bits determined by a coarse scaling factor; 2) a first limiter for receiving the D most significant bits of the output of the first shifter and outputting a subset of the D most significant bits of the first shifter output; 3) a first multiplier for multiplying the subset of the D most significant bits of the first shifter output by a fine scaling factor to produce a first M-bit product; and 4) a gain adjustment circuit for comparing a power signal derived from the first M-bit product to a maximum threshold value and generating the coarse scaling factor and the fine scaling factor.

A strut top mount is optimized to provide a resilient response to jounce and rebound load rates that is symmetrical and linear over a predetermined range of travel. An annular tower is formed of the body structure. A central bracket has adhered thereto an outer resilient element that abuts the tower, and has adhered oppositely thereto an inner resilient element. A bearing is supported by the central bracket, and a spring seat is supported by the bearing. A sleeve is received by a strut shaft and adhered to the inner resilient element A lower washer abuts a lower end of the inner resilient element. An upper washer abuts an upper end of the inner resilient element. A retention washer is mounted onto the strut shaft, wherein a periphery thereof has a retention washer resilient element. The components are collectively tuned to provide the optimization.

A detector system measures radioactive material. A fluid path receives at least one aliquot of radiopharmaceutical. The fluid path locates the aliquot within a positioner formed with a concave configuration. A detector is located at an axial distance from the concave surface and determines the level of radioactivity of the aliquot. Alternatively, the fluid path may be less concave and a variable attenuator may be placed between the fluid path and detector. The variable attenuator may have a concavity that is based on the concavity of the fluid path so that the detector's ability to read the radioactivity is optimized. A method for forming an aliquot of radiopharmaceutical in a concave fluid passage. Positioning a detector located a distance from the concave surface to optimize reading spectral energy of the aliquot and activity is determining activity regardless of the position of the aliquot in the passage.

A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.

A strut top mount is optimized to provide a resilient response to jounce and rebound load rates that is symmetrical and linear over a predetermined range of travel. An annular tower is formed of the body structure. A central bracket has adhered thereto an outer resilient element that abuts the tower, and has adhered oppositely thereto an inner resilient element. A bearing is supported by the central bracket, and a spring seat is supported by the bearing. A sleeve is received by a strut shaft and adhered to the inner resilient element A lower washer abuts a lower end of the inner resilient element. An upper washer abuts an upper end of the inner resilient element. A retention washer is mounted onto the strut shaft, wherein a periphery thereof has a retention washer resilient element. The components are collectively tuned to provide the optimization.

A filter / plug drain assembly for insertion into a drain so as to prevent the passage of selected contaminants through the drain is disclosed. The filter / plug assembly includes stacked layers of filter, filtering / plugging and plugging material. The filter / plug assembly has alternative internal flowpaths configured to provide different plugging speeds when exposed to ongoing low levels of selected contaminants.

Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.

A system and method for rule-based or algorithm-based automated response optimization in a marketing environment is provided. The system and method increases email or website open, click through, and fulfillment rates for advertisers, including newsletter advertisers, national retailers, manufacturers, non-profits and the like (“Customers”). Individuals who receive emails from any of the Customers or access websites with Customer's advertisements will become a Member through a simple enrollment process. The system and method rewards Members for opening, clicking through and / or fulfilling advertisements disseminated through emails or websites with a proprietary currency and trading floor. The rewards may be exchanges on the trading floor for coupons, goods, services and actual cash.

Methods and apparatus for the modulation of flame gas stoichiometry to a flame-based detector for use in chromatographic separations are presented. As the total mass flow rate of mobile phase entering the flame-based detector changes (e.g., as a result of density programming in the separation), the mass flow rate of combustion gases to the detector are altered in proportion to the amount of mobile phase entering the detector. As a result, flame stability and sensitivity of the detector can be maintained by the methods and apparatus of the present disclosure.

The invention relates to a virtual admittance controller based on static power converters, comprising a control loop into the inlet of which is injected the difference in voltage between a virtual internal voltage (e) and the voltage at the network connection point (v). Said difference in voltages feeds a virtual admittance processor (13) that determines the value of a reference current (i*) that it communicates to a current source (14), said current source physically injecting said current into the network (15).

The present disclosure relates to flame based detection methods for compressed mobile phase chromatography. In particular, the present disclosure relates to the operation of a flame ionization detector for carbon dioxide based chromatography, such as supercritical fluid chromatography. The present disclosure includes a method of matching a chromatographic column with a flame ionization detector inner burner including providing a chromatographic column with an internal diameter, determining an optimal mobile phase flow rate for the chromatographic column, calculating an optimal inner diameter of the inner burner that combined with the internal diameter and flow rate of the column produces optimal detector performance, and providing a flame ionization detector inner burner having an inner diameter substantially equal to the calculated optimal inner diameter.

A coiled tubing connector having a body and a plurality of entry or transition sections connected to the body wherein the connector has a low cycle fatigue life of at least 30%, more preferably at least 50% of the coiled tubing. A preferred embodiment contains two shoulders that form an annular void, a plurality of centralizers about an exterior of the body, and / or a plurality of elastomer molds separating the centralizers. The connector is preferably longer than the connectors of the prior art and is a composite of fluoroplastics or aluminum alloys.

An air quality monitor having multiple sensors deployed in an electric circuit returns a single sign indication of atmospheric impurity regardless of whether the impurity gas is of the oxidizing or reducing type. Each sensor employs a gas sensitive material that exhibits a response in the form of a change in electrical resistance of the material in the presence of a gas and that exhibits a negligible response to changes in the moisture content of the atmosphere. A powder is dried and calcined and the result is ground into a fine powder and pressed into a desired shape to make the gas sensitive material. Adding a binder during the pressing and firing the shaped powder results in a gas sensitive material with porosity. Gas is flowed to the gas sensitive material and the resulting change in resistance is measured and returned as a single sign indication of atmospheric impurity.

Preferred embodiments of the invention implement techniques for modifying the command trajectory, the architecture of a servomechanism control system, or both, to reduce the servo error during and / or after the command trajectory. An iterative refinement procedure generates for use by the servomechanism control system a corrective input, du, which significantly reduces the error between the desired and actual servomechanism control system outputs. In one embodiment, a uniquely identified plant model is employed in the iterative refinement procedure to compute an approximate gradient that improves the performance and reliability of the refinement procedure. In another embodiment, the actual plant response is used in place of the identified model in the iterative refinement procedure. This is accomplished by time-reversing the stored error signal from a training run, before applying it to the plant to generate an update to the corrective input signal du.

Preferred embodiments of the invention implement techniques for modifying the command trajectory, the architecture of a servomechanism control system, or both, to reduce the servo error during and / or after the command trajectory. An iterative refinement procedure generates for use by the servomechanism control system a corrective input, du, which significantly reduces the error between the desired and actual servomechanism control system outputs. In one embodiment, a uniquely identified plant model is employed in the iterative refinement procedure to compute an approximate gradient that improves the performance and reliability of the refinement procedure. In another embodiment, the actual plant response is used in place of the identified model in the iterative refinement procedure. This is accomplished by time-reversing the stored error signal from a training run, before applying it to the plant to generate an update to the corrective input signal du.

A coiled tubing connector having a body and a plurality of entry or transition sections connected to the body wherein the connector has a low cycle fatigue life of at least 30%, more preferably at least 50% of the coiled tubing. A preferred embodiment contains two shoulders that form an annular void, a plurality of centralizers about an exterior of the body, and / or a plurality of elastomer molds separating the centralizers. The connector is preferably longer than the connectors of the prior art and is a composite of fluoroplastics or aluminum alloys.