A versatile compartmentalized
cell culture device, with a selectively permeable membrane separating the compartments, provides many attributes relative to traditional devices. It can be configured for high-density
cell culture, co-culture, and sample
dialysis while rolling or standing still. It can also be configured for continuous movement of liquid between compartments. The wide combination of attributes not found in other membrane based
cell culture and bioprocessing devices includes more cell capacity, more cell secreted product capacity, higher cell and product density, increased medium capacity, minimized use of
exogenous growth factors, compatibility with
standard cell culture equipment and protocols, increased scale up efficiency, capacity to function when rolling or standing still, capacity for
perfusion without the need for pumps, and more efficient sample
dialysis.