The invention relates to a high-yield cultivation method for winter wheat in the Huanghuaihai region. The high-yield cultivation method comprises the following five main steps: (1) performing soil preparation and sowing; (2) managing before winter; (3) managing in spring; (4) managing in middle and later stages; and (5) harvesting. According to the technical mode of selecting a winter variety, returning straw to the field, applying fertilizers, performing deep loosening and deep digging, performing rotary tillage and soil preparation, performing broad accurate sowing, mechanically pressing, watering in winter, backwards shifting nitrogen fertilizers, spraying once to prevent pests and diseases, dry and hot wind and lodging, and mechanically harvesting, the high-quality wheat variety which is high in yield, stable in yield and strong in lodging resistance is selected, the soil fertility is raised, seeds are sowed at proper time, the proper pre-winter management is performed, the survival rate of the wheat seedlings is increased, and the uneven growth is prevented; organic fertilizers and inorganic fertilizers are reasonably combined, the technology of backwards shifting the nitrogen fertilizers and applying potassium in stages is applied, the nutrient needs of the wheat at different stages are sufficiently guaranteed, a reasonable group structure is established, the spikelet floret degeneration is reduced, the kernels per spike are increased, the functional period of green leaves is prolonged, the grain filling is promoted, the thousand seed weight is increased and the high-yield breakthrough is realized.