The invention discloses a multi-bed type ventilation air methane regenerative thermal oxidation device which is used in a ventilation air methane counter-flow thermal oxidation treatment process during production of coal mines. The device comprise three or more oxidation beds, a combustion chamber, a preheater, a ventilation air inlet pipe, a flue gas outlet pipe, a purging pipeline, a flue gas extraction pipeline, a switching valve and a control unit. Oxidation beds are in a vertical structure, heat-insulating fire-resisting materials are arranged on peripheries of oxidation beds, and in addition to a heat accumulation and heat release circulation, a purging purification process is added, so that unoxidized ventilation air is prevented from being directly exhausted into the air, and the oxidation rate exceeds 99%. Besides, flue gas extraction openings are arranged between high-temperature zones and low-temperature zones of oxidation beds, so that part of high-temperature flue gases can be extracted for waste-heat utilization. The device has the advantages of being high in oxidation rate of methane, convenient for waste-heat utilization, stable to operate and the like.