The invention relates to the field of pesticide chemistry, in particular to a piperazine amide derivative and a preparation method thereof, a root parasitic weed seed germination accelerator and a method for preventing and treating root parasitic weeds. In the derivative (See the specification for the formula), R<1>, R<2>, R<3>, R<4> and R<5> are respectively and independently selected from hydrogen, halogen, nitro, cyano, chain alkyl, alkyl containing a cyclic structure, alkoxy, halogenated alkoxy, alkylthio, ester group, alkyl sulfonyl and the like or are connected together to form a cyclicstructure, X is selected from O, S, SO, SO2 or CR<10>R<11>, R<6>, R<7>, R<10>, R<11> are each independently selected from hydrogen, halogen and C1-C4 alkyl or are connected together to form a three-membered ring, a four-membered ring or a five-membered ring, Z is selected from O or S, and R<8> and R<9> are each independently hydrogen or an alkyl group of C1 to C4. The piperazine amide derivative disclosed by the invention can be used as a root parasitic weed seed germination accelerator.