The invention provides a comprehensive power supply system with a remote monitoring function. The comprehensive power supply system comprises a box, wherein the box comprises a base plate, wall bodies and a top cover, and a high-voltage room, a transformer room, a low-voltage room and an industrial personal computer are arranged in the box; in a box-type substation, the high-voltage room, the transformer room and the low-voltage room are provided with doors and windows, and exhaust fans are arranged on the windows, so that natural ventilation and mechanical ventilation are combined, and maintenance is convenient; the wall bodies and clapboards on the circumference of the substation are respectively provided with inner-layer steel plates and outer-layer steel plates, a cavity is formed between each inner-layer steel plate and outer-layer steel plate, and fireproof sound-insulation cotton is arranged in each cavity; and radiation heat-dissipation cooling coating coats the surface of each outer-layer steel plate. The radiation heat-dissipation cooling coating can radiate object heat and achieve heat-dissipation waterproof functions; and the radiation heat-dissipation cooling coating can automatic radiate the heat of the coated object to an atmospheric space, reduces surface and interior temperature of the box-type substation and also achieves a soundproof function.