35 results about "Liu-wei-di-huang wan" patented technology

The invention relates to a quantitative determination method of pills of six ingredients with rehmannia, and a preparation method and application thereof. The adopted technical scheme is as follows: each millilitre of the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia contains 16.71-66.82 mu g of 5-hydroxymethylfurfural, 30.56-122.22 mu g of mrroniside, 19.52-78.06 mu g of loganin, 12.71-50.84 mu g of paeoniflorin, and 40.27-161.06 mu g of paeonol. The content determination of the pills of six ingredients with rehmannia is carried out by taking the contrast Chinese patent medicine extract of the pills of six ingredients with rehmannia provided by the invention as the standard substance and adopting a high-erformance liquid chromatography; therefore, the method is capable of simultaneously controlling a plurality of components, simplifying a checkout process and greatly reducing checkout cost and meets with the technology development tendency in the traditional Chinese checkout field; furthermore, the preparation method of the contrast extract is simple and convenient and is beneficial to being popularized and applied and has strong practicability.

The invention discloses a preparation method of Liuweidihuang pills. The preparation method adopts a diaphragm press filtration cycle extraction separation integrated technology to extract active ingredients of prescription drugs. The preparation method simplifies a process flow, shortens greatly a production period, saves energy consumption, is beneficial for environmental protection and dreg utilization, and improves greatly an active ingredient recovery rate.

The invention provides a maca composition, its compound preparation and application thereof. The invention provides a maca zinc composition, which uses maca powder and nutrient zinc as active components. The invention provides a Maca Liuwei Dihuang Wan composition, which uses maca powder and Liuwei Dihuang Wan extract as active ingredients. The invention provides a maca medlar composition, which uses maca powder, astragalus, medlar and soybean isoflavones as active ingredients. The invention provides a maca kudzu root composition, which uses maca powder, kudzu root and raspberry as active ingredients. The series of compositions can be made into tablets (pressed candies) and capsules by adding edible auxiliary materials. The compositions of the present invention are matched and combined according to their respective functional characteristics, and have a series of functions of invigorating kidney and strengthening yang, relieving physical fatigue, treating prostatitis, treating menopause syndrome and antidepressant.

The invention discloses a nano microcapsule for six ingredients with rehmannia and a preparation process thereof. The preparation process comprises the following steps of: taking the traditional pills for six ingredients with the rehmannia as a basis, adopting a multilevel dynamic hot reflux method for extraction and concentration of radix rehmanniae preparata, Poria cocos and rhizoma alismatis; carrying out nano-level crushing on dogwood, tree peony bark and yam; and uniformly mixing the nano fine powder and concentrated liquor according to certain proportion, carrying out freezing or spray-drying treatment, preparing the nano microcapsule, and finally adopting a corresponding preparation technology to prepare into a dosage form applicable on clinic. The process has the advantages of simple operation, short process flow, easy control of parameters, low cost, no toxic and side effects caused by organic reagents and the like. The nano microcapsule for six ingredients with the rehmannia can be directly used, and also can be used as a drug intermediate. In the nano microcapsule, the drug effect can be obviously delayed, the administration times and amount can be reduced, and the toxic and side effect caused by the traditional drug is reduced or eliminated. The nano microcapsule is concentrated by more than three times compared with the existing nano microcapsule product for six ingredients with the rehmannia on the market, and the total daily dosage can be reduced by 3-6 times compared with the traditional products such as the concentrated six ingredients with the rehmannia and the like.

The invention relates to gene detection compositions and application thereof, in particular to application of TMED2, CCDC72 and ERC1 genes in detection of postmenopausal osteoporosis and clinical medication of Liuweidihuang pills. The inventor conducts high-throughput sequencing on peripheral blood samples before and after postmenopausal osteoporosis patient take the Liuweidihuang pills and control peripheral blood samples of healthy persons by a high-throughput sequencing technology; the results shows that candidate genes TMED2, CCDC72 and ERC1 have obvious change after the postmenopausal osteoporosis patients take the Liuweidihuang pills, and further analysis results of high-throughput data are verified by a molecular biology experiment. The invention provides gene compositions for clinically and accurately diagnosing postmenopausal osteoporosis and accurate medication and has a good market application value.