53 results about "Intraventricular Cardiac" patented technology

The invention relates to a medical prosthesis, and in particular a heart valve substitute comprising a pliant tubular conduit mounted on a resilient annular frame and tethered to a non-perforating anchor within the right or left ventricle of the heart, wherein the pliant tubular conduit is a reciprocating mechanical member that is compressed by pressurized working fluid within the ventricle during systole.

The invention relates to a medical prosthesis, and in particular a tether platform for attaching to or mounting on the septomarginal trabecula of the right ventricle for securing and positioning heart valve repair devices, and in particular for securing a heart valve substitute comprising a pliant tubular conduit mounted on a resilient annular frame and tethered to a non-perforating anchor within the right ventricle of the heart, wherein the pliant tubular conduit is a reciprocating mechanical member that is compressed by pressurized working fluid within the ventricle during systole.

Cardiac resynchronization therapy is delivered to a heart using an extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay. The extended bipolar electrode configuration comprises a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a right ventricular electrode defining an anode of the extended bipolar electrode configuration. A pace pulse is delivered to the left ventricular electrode and anodal stimulation of the right ventricle is detected based on the sensed response to the pace pulse.

Pharmaceutical compositions are disclosed suitable for parenteral administration having anti-inflammatory, analgesic, and anti-pyretic properties, which consist of a therapeutically effective amount of d,l or l-lysine salt of R,S or S-ibuprofen as active ingredient dissolved in sterile water to form a solution in the absence of an inert atmosphere and either substantially free or absolutely free of any excipient, organic solvent, buffer, acid, base, salt other than the active ingredient and capable of storage in the absence of an inert atmosphere. Also disclosed are methods employing the new compositions in the treatment of pain and inflammation, in reducing fever and in treating patent ductus arterious or intraventricular hemorrhage in prematurely born neonates.

The invention relates to a medical prosthesis, and in particular a heart valve substitute comprising a pliant tubular conduit mounted on a resilient annular frame and tethered to a non-perforating anchor within the right or left ventricle of the heart, wherein the pliant tubular conduit is a reciprocating mechanical member that is compressed by pressurized working fluid within the ventricle during systole.

Cardiac resynchronization therapy is delivered to a heart using an extended bipolar electrode configuration in accordance with programmed pacing parameters including a non-zero intraventricular delay. The extended bipolar electrode configuration comprises a left ventricular electrode defining a cathode of the extended bipolar electrode configuration and a right ventricular electrode defining an anode of the extended bipolar electrode configuration. A pace pulse is delivered to the left ventricular electrode and anodal stimulation of the right ventricle is detected based on the sensed response to the pace pulse.

A ventricular assist device for intraventricular placement inside a heart of a mammalian subject includes a pump including a housing having an inlet end, an inlet at the inlet end, and an outlet. Thepump further includes a moveable element disposed in the pump housing for pumping blood from the inlet to the outlet. A base member is included as well as a spacer member connected to the pump housingand the base member. The base member is positioned a distance from the inlet end of the pump housing to define a gap therebetween. One or more sensor elements are mounted to at least one from the group consisting of the base member and the housing, the one or more sensor elements being configured to measure one or more blood parameters prevailing within the gap during operation of the pump.

The invention discloses a mitral valve device implanted through the atrial septum. The mitral valve device comprises a valve prosthesis and a ventricular anchoring part, wherein the valve prosthesis comprises a stent main body achieving a supporting effect and an artificial valve leaflet; the artificial valve leaflet is fixed at a preset position of the stent main body; and the ventricular anchoring part comprises a connecting part and an anchoring part attached to the inner wall of a ventricle, and the anchoring part is fixed to the stent main body through the connecting part. The invention further provides an implantation method of the mitral valve device. After the valve device is released, the valve prosthesis is fixed to the native valve ring and used for replacing a native valve to open or close a blood flow channel, and a ventricular anchoring part provides a firm anchoring force for the stent main body through the attachment effect of the anchoring part and the ventricular wallso as to prevent the stent main body from being impacted to the left atrium.

The invention discloses a blood circulation assisting device and a control system, and the blood circulation assisting device comprises a sheath tube which is used for being installed in a blood vessel and is provided with a near end and a far end; the first balloon is arranged on the sheathing canal and is positioned in the blood vessel; the pump body is arranged at the far end of the sheathing canal and provided with a blood flow channel, a blood inlet and a blood outlet, the blood inlet and the blood outlet are communicated with the blood flow channel, and the pump body is used for pumping blood in the cardiac chamber into the blood vessel; the controller is arranged at the near end of the sheathing canal, and is configured to control the operation of the pump body and intermittently drive the first balloon to inflate and deflate, so that the first balloon at least partially blocks the blood vessel to cooperate with the pump body to generate pulsatile blood flow. According to the blood circulation auxiliary device and the control system, pulsatile blood flow matched with the heart pulsatile characteristics of the patient can be generated, and heart recovery of the patient is promoted.

The invention provides a left ventricle segmentation method and device and electronic equipment, and the method comprises the steps of obtaining cardiac medical image data; determining a cardiac apexposition and a cardiac base position in the medical image data according to the heart physiological structure characteristics; determining a left ventricular cavity segmentation result by adopting a region growing algorithm based on the cardiac apex position and the cardiac base position; according to the left ventricular cavity segmentation result, performing segmentation based on a level set algorithm to obtain a left myocardial segmentation result; and combining the left ventricular cavity segmentation result and the left myocardial segmentation result to obtain a left ventricular segmentation result. As the apex and the heart base are located in the ventricle, an accurate left ventricular cavity segmentation result can be obtained by adopting a region growing method based on the apex and the heart base, and due to the fact that the left ventricular cavity and the left myocardium are large in gray scale difference and obvious in gray scale gradient change, accurate left myocardium segmentation is conducted through a level set algorithm on the basis of the left ventricular cavity segmentation result, and the evolution speed is fast.

The invention relates to implantable medical equipment for detecting T-wave over-perception by utilizing a pressure sensor. The implantable medical equipment comprises an electrocardiosignal perception wire and a pressure sensor integrated on the wire; the wire enters a ventricle through a coronary vein to maintain the pressure sensor within the ventricle; the implantable medical equipment furthercomprises a functional circuit; the functional circuit is electrically connected with the wire so as to receive the electrocardiosignal and an intraventricular pressure signal sensed by the pressuresensor; the functional circuit comprises a control module; the control module is configured to judge whether T-wave over-perception occurs or not according to the intraventricular pressure signal; thepressure sensor is used for detecting T-wave over-perception; and, compared with electric signal detection, the accuracy is relatively high.

An implanted medical device utilizing blood flow sensor to detect T wave over-perception. The implanted medical device comprises an ECG signal sensing wire and a blood flow sensor integrated on the wire, and the wire enters the ventricle through the coronary vein to keep the blood flow sensor in the ventricle; the implantable medical device also comprises a functional circuit, and the functional circuit is electrically connected with the wire to receive the ECG signal and the intraventricular blood flow signal sensed by the blood flow sensor; the functional circuit comprises a control module,and the control module is configured to judge whether T wave over-perception is occurs according to the intraventricular blood flow signal; and the detection of T wave over-perception by utilizing theblood flow sensor has higher accuracy than the detection relying on the electrical signals.

An implantable intracardiac device to prevent systolic anterior motion of the anterior mitral valve leaflet into the left ventricular outflow tract is described. The device comprises a blocking member configured for implantation within the left ventricle of the heart and in-situ blocking of systolic anterior motion of the mitral valve into the left ventricular outflow tract when anchored into the left ventricle of the heart. The device may be configured for radial expansion from a contracted orientation suitable for transluminal delivery to the left ventricle of the heart within a suitable delivery vehicle and an expanded orientation suitable for deployment within the left ventricle of the heart. The device comprises anchors configured for anchoring the device in-situ within the left ventricle to a wall of the left ventricle.

The invention discloses an application of multi-type mixed cells in myocardial infarction cell treatment, wherein the multi-type mixed cells are cells derived from vein bridge vessels after a vein istransplanted to an artery. The invention also provides the application of the multi-type mixed cells as a medicament for preventing or treating myocardial infarction. When the multi-type mixed cell disclosed by the invention is applied to myocardial infarction treatment, the cardiac function after myocardial infarction can be improved, the left ventricular ejection fraction can be increased, the infarct area and the wall thickness can be reduced, and the inner diameter of the ventricle can be reduced, so that symptoms can be improved, and the application has important clinical significance.

The invention provides an intraventricular pulsating blood pump fixedly disposed at the ventricularapex inside the ventricle to generate pulsation action. The pulsating blood pump is substantially jellyfish-shaped and includes a bell-shaped pump body and a driving source, an opening of the bell-shaped pump body faces to the outlet of the ventricle, the driving source drives the bell-shaped pump body to contract or relax, and the contraction or relaxation of the bell-shaped pump body drives the blood in the ventricle to eject directionally to the artery and form a convoluted blood flow field between the inner wall of the bell-shaped pump body and the inner wall of the ventricle. The invention not only provides assist to ventricular by pulsating blood flow, but also optimizes the flow field and pressure distribution in the ventricle, the blood pump of the invention is better in biocompatibility than the blood pumps in prior art.

The invention provides a left ventricle inner and outer membrane automatic segmentation method, system and equipment, and belongs to the technical field of nuclear magnetic resonance. The method comprises the following steps: extracting a region of interest on each layer of image of left ventricle magnetic resonance imaging (MRI), and respectively positioning a left ventricle blood pool region; judging whether the blood pool area of the MRI image of the current layer contains a left ventricular outflow tract LVOT or not, and respectively extracting a left ventricular intima contour containing the LVOT and a left ventricular intima contour not containing the LVOT by adopting different methods; and determining an internal mark of the left ventricular intima contour based on morphological expansion, marking an external mark at a proper position of the myocardial area, and extracting the left ventricular adventitia contour by adopting a watershed algorithm based on mark control. By using the method provided by the invention, the accuracy of segmenting the left ventricular inner and outer membranes is high, and the stability and the universality are good.

An implantable cardioverter defibrillator (ICD) system includes an internal electrode placed in the right ventricle of the heart, and a quasi-Faraday cage (which includes a single or multiple electrodes) placed over a significant portion of the heart. Defibrillation shocks are applied between the internal electrode in the ventricle and the electrode(s) of the quasi-Faraday cage. Because the quasi-Faraday cage surrounds a significant portion of the heart, it functions as a quasi-Faraday cage and is capable of confining a significant portion of the defibrillation shock field to the heart itself so as to reduce pain. Application of shocks is thus less painful to the patient.

The invention provides a valve annular constriction device. The valve annular constriction device comprises an anchoring part and a tightening line, and the anchoring part comprises an anchoring needle and a tensioning piece; the anchoring needle comprises a puncture head, a connecting rod and a base, and the puncture head is used for puncturing into the inner wall of a ventricle; the connecting rod is provided with a limiting groove, and the tensioning piece is inserted outside the connecting rod in a sleeving mode and connected into the limiting groove in a clamped mode; a tightening line hole is formed in the middle of the base and used for the tightening line to penetrate through; and a connecting hole detachably connected with a pushing rod of a conveying device is formed in the bottom of the base. According to the annular constriction, valve leaflets and a subvalvular structure of a mitral valve are reserved, a left ventricular structure is reserved to the maximum extent, and heart recession is relieved; and the treatment effect of mitral regurgitation is improved.

A device, system, and method for delivering energy to tissue. In particular, the present invention relates to a system and method for enhancing lesion formation without arrhythmogenic effects within relatively thick target tissues, such as the ventricles of the heart. In one embodiment, charge-neutral pulses and non-charge-neutral pulses may be delivered to induce the formation of electrolytic compounds that enhance cell death at the treatment site. Additionally or alternatively, tissue at the treatment site may be heated to sub-lethal temperature before ablating the tissue.

An implantable ventricular assist device comprises an intraventricular stent used for the creation of an artificial chamber inside the ventricle, a balloon-like structure used to drive the change of the artificial chamber between a contractile configuration and a diastolic configuration, a power system used for driving the change of the balloon-like structure between the contractile configuration and the diastolic configuration. There is also a power system and a mechanical design to operate the system working, wherein in the contractile configuration, the balloon-like structure expands and occupies the space of the artificial chamber and drives the blood inside the artificial chamber flow outside the artificial chamber, wherein in the diastolic configuration, the balloon-like structure shrinks and releases the space inside the artificial chamber, and the blood outside the artificial chamber flows back into the artificial chamber. It is easy to reach the goal of cardiac function.

Apparatus is provided, including a flexible intraventricular receptacle positionable within a heart ventricle, and configured to assume a first volume upon passage of fluid that is not blood into the receptacle and a second, smaller volume upon passage of the fluid out of the receptacle. An expandable extracardiac receptacle is positionable outside of the heart, and is configured to expand upon transfer of the fluid into the extracardiac receptacle from the intraventricular receptacle and to contract upon passage the fluid out of the extracardiac receptacle. A transmyocardial conduit is disposed and allows passage of the fluid between the intraventricular receptacle and the extracardiac receptacle responsively to a cardiac cycle. During ventricular systole, a volume of fluid is expelled from the intraventricular receptacle, through the conduit, and the extracardiac receptacle, producing a corresponding decrease in a total volume of the ventricle during isovolumetric contraction of the ventricle.

An implantable intracardiac device to prevent systolic anterior motion of the anterior mitral valve leaflet into the left ventricular outflow tract is described. The device comprises a blocking member configured for implantation within the left ventricle of the heart and in-situ blocking of systolic anterior motion of the mitral valve into the left ventricular outflow tract when anchored into the left ventricle of the heart. The device may be configured for radial expansion from a contracted orientation suitable for transluminal delivery to the left ventricle of the heart within a suitable delivery vehicle and an expanded orientation suitable for deployment within the left ventricle of the heart. The device comprises anchors configured for anchoring the device in-situ within the left ventricle to a wall of the left ventricle.

The invention provides an intraventricular pulsating blood pump fixedly disposed at the ventricularapex inside the ventricle to generate pulsation action. The pulsating blood pump is substantially jellyfish-shaped and includes a bell-shaped pump body and a driving source, an opening of the bell-shaped pump body faces to the outlet of the ventricle, the driving source drives the bell-shaped pump body to contract or relax, and the contraction or relaxation of the bell-shaped pump body drives the blood in the ventricle to eject directionally to the artery and form a convoluted blood flow field between the inner wall of the bell-shaped pump body and the inner wall of the ventricle. The invention not only provides assist to ventricular by pulsating blood flow, but also optimizes the flow field and pressure distribution in the ventricle, the blood pump of the invention is better in biocompatibility than the blood pumps in prior art.

An implantable ventricular assist device comprises an intraventricular stent used for the creation of an artificial chamber inside the ventricle, a balloon-like structure used to drive the change of the artificial chamber between a contractile configuration and a diastolic configuration, a power system used for driving the change of the balloon-like structure between the contractile configuration and the diastolic configuration. There is also a power system and a mechanical design to operate the system working, wherein in the contractile configuration, the balloon-like structure expands and occupies the space of the artificial chamber and drives the blood inside the artificial chamber flow outside the artificial chamber, wherein in the diastolic configuration, the balloon-like structure shrinks and releases the space inside the artificial chamber, and the blood outside the artificial chamber flows back into the artificial chamber. It is easy to reach the goal of cardiac function.

An implantable intracranial pulse pressure modulator for treating hydrocephalus in patients of all ages is disclosed as well as a system and method for use of the same. In one embodiment of the implantable intracranial pulse pressure modulator, two one-way valves are interposed in parallel, opposing orientations between a vestibule and a chamber. One of the one-way valves, in response to systole, provides fluid communication from the vestibule to the chamber such that a small aliquot of cerebrospinal fluid (CSF) is displaced from a cerebral ventricle into a ventricular catheter, thereby reducing intraventricular systolic pressure. The other one-way valve, in response to diastole, provides fluid communication from the chamber to the vestibule such that the same volume of CSF is reintroduced into a cerebral ventricle, thereby increasing intraventricular diastolic pressure. Together, both processes work synergistically to reduce intraventricular pulse pressure in order to treat hydrocephalus.

The invention discloses a cardiac apex mediated heart volume reduction implant which comprises a braid base, an umbrella-shaped frame on the braid base, and an isolating membrane on the umbrella-shaped frame, wherein the umbrella-shaped frame comprises supporting bars towards the upper part of the outer side; and the upper ends of the supporting bars are bent to form horizontal folds. The heart volume reduction implant aims at characteristics and needs of minimally invasive intervention treatment, particularly the contractility of the braid base is improved by optimizing the structure of the braid base and the structure of the umbrella-shaped frame, and the heart volume reduction implant is facilitated to be loaded into a delivery system, so that the diameter of delivery catheter can be reduced, and damage of endovascular tissues in the implantation process is reduced. Moreover, enough thickness of the braid base is ensured, the effect of automatically adjusting the height of the heart volume reduction implant can be achieved, and the supporting bars with horizontal folds are adopted in the implant, so that the implant is facilitated to be fully unfolded without being influenced by a ventricular space in the release process, and the implant can be firmly fixed on the premise of not damaging ventricular walls.

The invention discloses a pulse-adjustable TAVR operation simulator which comprises a control box. An LCD display screen is arranged on the control box, the LCD display screen is connected with a control panel in the control box, an adjustable flow button, an adjustable frequency button and a power supply main switch are arranged on the control box, and the LCD display screen, the adjustable flow button and the adjustable frequency button are respectively connected with the 7V voltage power supply module, the 24V voltage power supply module and the UART interface end; the power main switch is connected with the main power supply module; the control panel is connected with a submersible pump which is connected with a simulated blood vessel pipeline in the water tank; when a frequency button of the LCD display screen is pressed down, the control panel sends a signal to the submersible pump, the submersible pump performs intermittent action, and when the submersible pump discharges water, the submersible pump penetrates through the aortic valve from the ventricle to reach the ascending aorta, the aortic valve is opened and the submersible pump sucks water, the pressure in the ventricle is reduced, the ascending aorta applies pressure to the aortic valve, and the aortic valve is closed; and a complete heart cycle is simulated. The simulator has the characteristics of high reliability, quick response, small size and easiness in assembly.

The invention belongs to the technical field of medical instruments, and particularly relates to a ventricular assist device and an application method thereof. The ventricular assist device includes astand, a connecting line and an anchoring structure, wherein the stand includes a plurality of elastic support arms and an annular support, the rears of the elastic support arms are connected to theannular edge of the annular support so as to form a claw-shaped support structure which is adapted to the ventricular structure and applied to radial support of the inner wall of the ventricle, and the anchoring structure is anchored in the ventricle; the annular support is connected with the anchoring structure through the connecting line so as to fix the stand in the ventricle, the outer sides of the elastic support arms are in contact with the inner wall of the ventricle, and the elastic support arms are compressed by force when the ventricle contracts, and restores and expands when ventricular diastole occurs. The ventricular assist device can be compressed during ventricular contraction, so that energy is stored, and a radial support force is generated; ventricular diastole is assisted through the radial support force during ventricular diastole, so that heart functions are improved; and the ventricular assist device has a simple structure and high compatibility.

A ventricular assist device for a mammalian heart is disclosed that includes an aortic lumen member, the aortic member communicating with the interior of the aorta, an indwelling pump mechanism and a cardiac lumen member. The cardiac lumen member has at least one lumen tube that is connected to at least one intraventricular clamp that is connected to the inter chamber septum when the ventricular assist device is in the use position and is connected to at least one vertical septal clamp, the ventricular septal clamp is connected to the exterior facing myocardial tissue when the ventricular assist device is in the use position and at least a portion of the cardiac lumen tube extends through one of the cardiac chambers and a portion of the cardiac lumen extends from the ventricular septal clamp to the indwelling pump mechanism.

A ventricular assist assembly, for assisting a heart,includes an anchoring device, a cardiac pump and a stabilizing device. The anchoring device anchors a cardiac pump, is intended to be assembled with an opening in a ventricular wall of the heart, and delimits an internal passage.The cardiac pump is intended to be attached to the anchoring device, is configured for intra-ventricular insertion into the heart, and has a distal end.The cardiac pump extends through the internal passage into the heart when attached to the anchoring device implanted in the opening so that its distal end is placed in a ventricular chamber.The stabilizing device stabilizes the cardiac and includes at least two elongate, biocompatible and flexible connecting members, each elongate connecting member being intended to connect a part of the cardiac pump that is positioned in the ventricular chamber to an internal wall of the ventricular chamber.