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Enhanced electroporation of cardiac tissue

A technology of target tissue and charge, which is applied in the field of treating cardiac arrhythmia, and can solve problems such as short circuit of equipment, high voltage, ohmic heating of conductors, etc.

Active Publication Date: 2019-12-13
美敦力快凯欣有限合伙企业
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Furthermore, although the use of pulsed field ablation (PFA) for inducing IRE is generally safe and effective, in some cases, application to tissue contacting electrodes is required due to possible loss of electrical insulation on conductors within the treatment device. The voltage can be unacceptably high, which can cause the device to malfunction due to short circuits and ohmic heating of conductors within the device

Method used

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  • Enhanced electroporation of cardiac tissue
  • Enhanced electroporation of cardiac tissue
  • Enhanced electroporation of cardiac tissue

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Embodiment Construction

[0047] The devices, systems, and methods disclosed herein are used to ablate tissue using multiple waveform energy delivery that may include high amplitude short pulse duration biphasic charge-neutral pulses with high amplitude pulses between or in combination with high amplitude pulses. A combination or sequence of a series of lower amplitude non-charge neutral pulses delivered by amplitude pulses. These lower amplitude pulses may be monophasic or biphasic with a DC offset such that they impose a current flow through the affected tissue. In any event, the pulses should be very short, with a pulse duration of less than 50 microseconds and preferably less than about 20 microseconds to avoid inducing arrhythmias. In such tissues, this DC energy between the anode and cathode will produce a change in acid-base balance and reactive oxygen species on the anode will enhance and increase targeted cell death. Such a system would include charge monitoring from the generator for determi...

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Abstract

A device, system, and method for delivering energy to tissue. In particular, the present invention relates to a system and method for enhancing lesion formation without arrhythmogenic effects within relatively thick target tissues, such as the ventricles of the heart. In one embodiment, charge-neutral pulses and non-charge-neutral pulses may be delivered to induce the formation of electrolytic compounds that enhance cell death at the treatment site. Additionally or alternatively, tissue at the treatment site may be heated to sub-lethal temperature before ablating the tissue.

Description

technical field [0001] The present invention relates to devices, systems and methods for treating cardiac arrhythmias. In particular, the present invention relates to systems and methods for enhancing lesion formation in relatively thick target tissue, such as the ventricles of the heart, without causing arrhythmic effects. Background technique [0002] Arrhythmias can often be corrected by ablating or destroying heart cells that originate, support, or otherwise contribute to the propagation of faulty conduction pathways or signals in the heart that ultimately interfere with normal heart electrical activity and function . For example, an arrhythmia may manifest as atrial fibrillation under certain circumstances, such as in the relatively thin tissue of the atria, or when present in or involving thicker ventricular tissue , which can lead to other serious conditions (such as ventricular tachycardia). [0003] Of the various forms of energy that can be delivered to accompli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/12A61B18/04A61B18/14
CPCA61B2018/00029A61B2018/00886A61B2018/1246A61B2018/126A61B2018/1425A61B2018/1435A61B2218/002A61B18/1492A61N1/327A61N1/0595A61N1/403A61B18/1206A61B2018/00577A61B2018/00351A61B2018/00357
Inventor M·T·斯图沃特B·T·霍华德S·J·弗拉艾思奇
Owner 美敦力快凯欣有限合伙企业
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