30 results about "Collagenase Inhibitor" patented technology

The invention discloses an enzyme unhairing method for removing damage to a cowhide leather grain surface. The enzyme unhairing method is characterized in that at 35-42 DEG C, at first, a collagenase inhibitor of which the tare is 0.1-1.0% is used for pre-processing cowhide subjected to soaking and meat removal under the condition that the pH value is 7.5-11.5, then an unhairing enzyme preparation is added by routine to carry out unhairing treatment for 3-9 hours, and the follow-up processes such as mechanical unhairing, liming, deliming, softening, picking and tanning are performed by routine. The cowhide is pre-processed by the collagenase inhibitor before the operation of enzyme unhairing is performed, so that on one hand, collagenase in unhairing enzyme components is inhibited, the safety implementation of enzyme unhairing at a relatively high temperature is ensured, the enzyme unhairing time is greatly shortened, the efficiency is greatly improved, and the suitability for industrial production and application is achieved, on the other hand, the collagenase inhibitor has little impact on the activity of casease in the unhairing enzyme preparation, so that efficient unhairing efficiency is remained, the obtained leather grain surface is intact and undamaged, pores are clear, and the probability of surface looseness is low.

This invention reveals a novel skin-rejuvenating method that combines the application of light physics (a Light emitting diode (LED) device with specific wavelength, intensity, and pulsing frequency) and biochemistry (a specific collagenase inhibitor). The programmed LED light can penetrate skin epidermis and activate the fibroblasts in dermis to produce new collagen. Meanwhile, the overproduction of collagen leads to the feedback activation of collagenase, which degrades collagen and eliminates the beneficiary effects of LED light. Hence, this invention also includes a topical cream containing a certain lipophilic collagenase inhibitor, which, when used alone or in combination with the light device, can maintain high levels of skin collagen, and eventually achieve the long term effects of reducing wrinkles, enhancing skin elasticity, and diminishing eye bags and dark circles. The light device and active-containing cream have achieved positive effects when tested in human trials.

A method for purifying an oligomeric proanthocyanidin, comprising an extraction step of extracting a raw material containing multiple types of oligomeric proanthocyanidins having different degrees of polymerization with an extraction solvent selected from water and an aqueous alcohol solution, wherein the alcohol concentration in the extraction solvent is preset in accordance with the degree of polymerization of a desired oligomeric proanthocyanidin in the extraction step and the oligomeric proanthocyanidin having a desired degree of polymerization is extracted using the extraction solvent.

The invention provides a preparation method of a biological membrane as well as a product and application of the biological membrane. The preparation method of the biological membrane comprises the following steps: (1) treating animal cavity tissues by adopting a collagenase inhibitor; (2) removing a membrane layer which accounts for more than 40% of the total fat content of animal cavity tissues; (3) treating a product obtained in the step (2) by adopting a first enzyme solution; (4) treating a product obtained in the step (3) by adopting an alkali solution; (5) treating a product obtained in the step (4) by adopting a decellularized solution; (6) treating a product obtained in the step (5) by adopting a degreasing fluid solution; (7) treating a product obtained in the step (6) by adopting a second enzyme solution; and (8) cleaning the product obtained in the step (7) by adopting supercritical carbon dioxide to obtain the biological membrane. The integrity of a multi-layer space structure, elastic fibers and a collagen net structure of the biological membrane can be reserved to a great extent, the mechanical strength is high, residues of organic matters and reagents in the product can be removed, and the tissue regeneration inducing effect of the product is better.

The invention discloses an enzyme unhairing method for removing damage to a cowhide leather grain surface. The enzyme unhairing method is characterized in that at 35-42 DEG C, at first, a collagenase inhibitor of which the tare is 0.1-1.0% is used for pre-processing cowhide subjected to soaking and meat removal under the condition that the pH value is 7.5-11.5, then an unhairing enzyme preparation is added by routine to carry out unhairing treatment for 3-9 hours, and the follow-up processes such as mechanical unhairing, liming, deliming, softening, picking and tanning are performed by routine. The cowhide is pre-processed by the collagenase inhibitor before the operation of enzyme unhairing is performed, so that on one hand, collagenase in unhairing enzyme components is inhibited, the safety implementation of enzyme unhairing at a relatively high temperature is ensured, the enzyme unhairing time is greatly shortened, the efficiency is greatly improved, and the suitability for industrial production and application is achieved, on the other hand, the collagenase inhibitor has little impact on the activity of casease in the unhairing enzyme preparation, so that efficient unhairing efficiency is remained, the obtained leather grain surface is intact and undamaged, pores are clear, and the probability of surface looseness is low.

The invention discloses skin lotion and a preparation method thereof. The skin lotion is prepared from the following components by weight: (1) 30 to 60 parts of honeysuckles, (2) 20 to 50 parts of radix isatidis, (3) 10 to 20 parts of scutellaria baicalensis, (4) 5 to 10 parts of cordate houttuynia, (5) 1 to 3 parts of sodium chloride, (6) 1 to 3 parts of mint oil, (7) 2 to 10 parts of collagen, (8) 2 to 5 parts of a collagenase inhibitor, (9) 2 to 5 parts of an elastase inhibitor, and 300 to 500 parts of deionized water. The skin lotion has the effects of whitening and moistening the skin andkilling germs on the skin, goes green and is environmentally friendly.

The invention discloses a collagenase inhibitor composition, an anti-aging moisture dew and a preparation method of the anti-aging moisture dew. The collagenase inhibitor composition comprises 50-99%of a Chinese wolfberry extract and 1-50% of a ginseng extract, and the mass ratio of the ginseng extract to the Chinese wolfberry extract is preferably 1: 3-15. The anti-aging moisture dew comprises the collagenase inhibitor composition and a penetration enhancer, the addition amount of the collagenase inhibitor composition is 0.01-10%, and the collagenase inhibitor composition comprises 50-99% ofthe Chinese wolfberry extract and 1-50% of the ginseng extract; wherein the addition amount of the penetration enhancer is 0.01%-10%, and the penetration enhancer is bis-diethoxydiethylene glycol cyclohexane 1, 4-dicarboxylate. According to the collagenase inhibitor composition, the Chinese wolfberry extract and the ginseng extract are matched, so that a synergistic effect is achieved, and the activity of collagenase can be well inhibited. The anti-aging moisture dew can reduce degradation of collagen, has an anti-aging effect, also has moisturizing and water locking effects, can prevent moisture loss, and creates a moisturizing barrier for the skin.

The invention relates to a collagenase inhibitor, a preparation method of the collagenase inhibitor and skin penetrating water containing the collagenase inhibitor. The collagenase inhibitor comprises a wild chrysanthemum flower extract and a calendula extract, and the addition amount of the wild chrysanthemum flower extract is 26.2 to 73.8 percent based on the total mass of the collagenase inhibitor, and the addition amount of the calendula extract is 26.2 to 73.8 percent based on the total mass of the collagenase inhibitor. The collagenase inhibitor of the present invention has an excellent inhibitory effect on the activity of collagenase, and has no side effects on the human body.

The invention provides a skin refreshing lotion, a preparation method of the skin refreshing lotion and a collagenase inhibitor. The skin refreshing lotion comprises the collagenase inhibitor and a penetration enhancer; the addition amount of the collagenase inhibitor is 0.01-10% based on the total mass of the skin refreshing lotion; the addition amount of the penetration enhancer is 0.01-10%; and the collagenase inhibitor comprises a ginseng extract and a chamomile extract, based on the total mass of the collagenase inhibitor, the addition amount of the ginseng extract is 30-70%, and the addition amount of the chamomile extract is 30-70%. According to the present invention, the formula of the skin refreshing lotion is mild, and the skin elasticity can be effectively improved, so that the anti-aging effect is achieved.

The invention provides a collagenase inhibitor, eye essence containing the collagenase inhibitor and a preparation method of the eye essence. The collagenase inhibitor includes a rhodiola crenulata extract and a chamomile extract; and based on the total mass of the collagenase inhibitor, the addition of the rhodiola crenulata extract is 3-30%, and the addition of the chamomile extract is 70-97%. The collagenase inhibitor has excellent inhibition effects on the activity of collagenase, and has no side effects on human bodies.

The invention discloses an anti-enzymolysis collagen compound and application thereof, the anti-enzymolysis collagen compound is composed of polymer microspheres carrying one or more collagenase inhibitors and collagen, the mass ratio of the polymer microspheres to the collagen is 1: 20-20: 1, and the anti-enzymolysis collagen compound can be cross-linked as required. The collagenase inhibitor is carried and slowly released through the polymer microspheres, so that the collagenase activity in a local environment is reduced, the decomposition rate of a collagen product in tissues is reduced, the action time of the collagen product is prolonged, the replacement and use frequency of the collagen product can be reduced, and the use cost of the collagen product is reduced.

The invention provides a moisture dew, a collagenase inhibitor and a preparation method of the water dew and the collagenase inhibitor. The moisture dew comprises the collagenase inhibitor and a penetration enhancer, and the addition amount of the collagenase inhibitor is 0.01-10% based on the total mass of the moisture dew; the addition amount of the penetration enhancer is 0.01-10%; and the collagenase inhibitor comprises a poria cocos extract and a ginseng extract, based on the total mass of the collagenase inhibitor, the addition amount of the poria cocos extract is 10-45%, and the addition amount of the ginseng extract is 55-90%. According to the present invention, the moisture dew is mild in formula and can effectively improve skin elasticity, so that the anti-aging effect is achieved.

The invention discloses a biochemical skin-beautifying method and beautifying cream used therein. In the skin-beautifying method, the beautifying cream with a specific collagenase inhibitor as a core is used, wherein compared with a collagenase inhibitor disclosed in the prior art, the collagenase inhibitor can better keep collagen in skin at a high level, so that long-term effects of removing wrinkles from the facial skin, enhancing the elasticity and eliminating bags under the eyes and dark circles are achieved.

The invention discloses a method for improving skin wrinkle resistance through enzyme inhibitors, comprising the steps of coating wrinkle resistance essence on wrinkles, uniformly applying the wrinkleresistance essence to wrinkles, and preparing the wrinkle resistance essence from the following components by weight percentage: collagen of 25-30%; phycocyanin of 5-15%; glycerol polyacrylate of 5-8%; deionized water of 40-50%; hydroxyphenyl isobutyl ester of 1%-3%; wheat germ glyceride of 1-2%; whey protein of 2-8%; natural squalane of 1%-2%; collagenase inhibitor of 1-3%; lavender oil of 0.5%-1%; arbutin of 2-3%; and aloe gel of 1-2%; wherein the sum of the weight percentages of the components is 100%. Novel design, can resist muscle wrinkles, dermal wrinkles and dry lines have a rapid improvement effect, but also smooth skin surface, delicate, soft, luster, is a very good innovative program, a very good market promotion prospects.

The invention discloses a collagenase inhibitor composition, an anti-aging face cream, a preparation method of the anti-aging face cream. The collagenase inhibitor composition comprises the followingcomponents in percentage by mass: 50-99% of licorice root extract and 1-50% of chamomile extract, wherein the mass ratio of the chamomile extract to the licorice root extract is preferably 1: 1-9. Theanti-aging face cream comprises a collagenase inhibitor composition and a penetration enhancer; and based on the total mass of the anti-aging face cream, the addition amount of the collagenase inhibitor composition is 0.01-10%, and the addition amount of the penetration enhancer is 0.01-10%. The collagenase inhibitor composition comprises 50-99% of licorice root extract and 1-50% of chamomile extract; and the penetration enhancer is bis-ethoxydiglycol cyclohexane 1,4-dicarboxylate. According to the collagenase inhibitor composition, the licorice root extract and the chamomile extract are matched, the synergistic interaction effect is achieved, and the activity of collagenase can be well inhibited. The anti-aging face cream can reduce degradation of collagen, has an anti-aging effect, hasmoisturizing and water locking functions, can stop water loss and creates a moisturizing barrier for skin.

The invention provides an essence stock solution, a preparation method thereof and a collagenase inhibitor. The essence stock solution comprises the collagenase inhibitor and a penetration enhancer, wherein on the basis of the total mass of the essence stock solution, the mass of the added collagenase inhibitor accounts for 0.01%-10%, and the mass of the added penetration enhancer accounts for 0.01%-10%; and the collagenase inhibitor comprises a poria cocos extract and a calendula extract, wherein on the basis of the total mass of the collagenase inhibitor, the mass of the added poria cocos extract accounts for 10%-49%, and the mass of the added calendula extract accounts for 51%-90%. The essence stock solution is mild in formula and can effectively improve skin elasticity, so that an anti-aging effect is achieved.

The invention discloses an ocular surface biofilm fixation device. The fixation device is annular with a radian, and the radian coincides with the radians of the eyeball surface and the upper and lower fornix conjunctiva. The inner surface of the fixation device (in contact with the eyeball surface) can also be provided with grooves. The fixation device for ocular surface biofilm is easy to operate and does not require surgery; the amniotic membrane can be replaced repeatedly at any time to maximize the use of amniotic membrane to resist infection, promote the recovery of injured ocular surface cells, inhibit new blood vessels, and inhibit the activity of collagenase inhibitors ; avoid symblephane and reduce fornix narrowing; avoid subamniotic effusion; do not cause new trauma to the ocular surface, reduce the occurrence and development of corneal limbal granulation, can cover the cornea, bulbar conjunctiva surface, palpebral conjunctiva surface, fornix conjunctiva surface, eliminate It eliminates the dead angle of amniotomy coverage; it does not need to use instruments or sutures to open the eyelids like amnion coverage, so that it does not damage the eyelids and other advantages.

An object of the present invention is to provide hyaluronidase inhibitors, collagenase inhibitors, elastase inhibitors, MMP-1 production suppressors, and collagen synthesis promoters that contain as an active component one or more pigment compounds that are obtained as extracted from plants of the family Rosaceae, as well as agents for cutaneous application, skin cosmetics, and quasi-drugs that contain such pigment compounds. The present invention provides hyaluronidase inhibitors, collagenase inhibitors, elastase inhibitors, MMP-1 production suppressors, collagen synthesis promoters, agents for cutaneous application, skin cosmetics, and quasi-drugs that contain one or more compounds in a class of rosacyanins or one or more compounds in a class of rosadelphins as an active component.

The invention provides a preparation method of a biofilm and its product and application. The preparation method of the biofilm comprises the following steps: (1) using a collagenase inhibitor to treat the animal cavity tissue; (2) removing the film layer accounting for more than 40% of the total fat content of the animal cavity tissue; (3) using the first The product obtained in the enzyme solution treatment step (2); (4) the product obtained in the alkali solution treatment step (3); (5) the product obtained in the decellularization solution treatment step (4); (6) the degreasing solution treatment The product obtained in step (5); (7) using the second enzyme solution to treat the product obtained in step (6); (8) cleaning the product obtained in step (7) with supercritical carbon dioxide to obtain a biofilm. The invention can largely retain the integrity of the multi-layer space structure of the biofilm, the elastic fiber and the collagen network structure, has high mechanical strength, can remove the residues of organic matter and reagents in the product, and has a better effect of inducing tissue regeneration .

The invention provides a tightening cream, a preparation method thereof and a collagenase inhibitor. The tightening cream comprises the collagenase inhibitor and a penetration enhancer, based on the total mass of the tightening cream, the addition amount of the collagenase inhibitor is 0.01-10%, and the addition amount of the penetration enhancer is 0.01-10%; the collagenase inhibitor comprises a red pomegranate bark extract and a grapefruit extract, and based on the total mass of the collagenase inhibitor, the addition amount of the red pomegranate bark extract is 15-65%, and the addition amount of the grapefruit extract is 35-85%. The tightening cream disclosed by the invention is mild in formula, and can effectively improve skin elasticity, so that an anti-aging effect is achieved.

The invention provides a beauty fluid, a preparation method thereof and a collagenase inhibitor. The beauty fluid comprises the collagenase inhibitor and a penetration enhancer; based on the total mass of the beauty fluid, the addition amount of the collagenase inhibitor is 0.01-10%; the addition amount of the penetration enhancer is 0.01-10%; the collagenase inhibitor comprises a pomegranate peel extract and a chamomile extract; and based on the total mass of the collagenase inhibitor, the addition amount of the pomegranate peel extract is 28-72%, and the addition amount of the chamomile extract is 28-72%. The beauty fluid provided by the invention is mild in formula, and can effectively improve skin elasticity, and thus, an effect of resisting aging is achieved.

The invention provides a collagenase inhibitor, an anti-aging skin-brightening toner containing the collagenase inhibitor and preparation methods. The collagenase inhibitor comprises a red pomegranate bark extract and a purslane herb extract, based on the total mass of the collagenase inhibitor, the addition amount of the red pomegranate bark extract is 26-74%, and the addition amount of the purslane herb extract is 26-74%. The collagenase inhibitor of the invention has an excellent inhibitory effect on the activity of collagenase, and has no side effects on the human body.

The invention discloses a biochemical skin-beautifying method and beautifying cream used therein. In the skin-beautifying method, the beautifying cream with a specific collagenase inhibitor as a core is used, wherein compared with a collagenase inhibitor disclosed in the prior art, the collagenase inhibitor can better keep collagen in skin at a high level, so that long-term effects of removing wrinkles from the facial skin, enhancing the elasticity and eliminating bags under the eyes and dark circles are achieved.

The invention provides moisturizing cream, a preparation method of the moisturizing cream and a collagenase inhibitor. The moisturizing cream includes the collagenase inhibitor and a permeation enhancer; and based on the total mass of the moisturizing cream, the addition of the collagenase inhibitor is 0.01-10%, and the addition of the permeation enhancer is 0.01-10%. The collagenase inhibitor includes a pomegranate peel extract and a sophora angustifolia root extract; and based on the total mass of the collagenase inhibitor, the addition of the pomegranate peel extract is 51-95%, and the addition of the sophora angustifolia root extract is 5-49%. The moisturizing cream is mild in formula and can effectively improve the elasticity of skins, so that anti-aging effects can be achieved.

The invention provides a collagenase inhibitor, a repair cream containing the collagenase inhibitor and a preparation method of the repair cream. The collagenase inhibitor comprises a ginseng extract and a radix sophorae flavescentis root extract, and based on the total mass of the collagenase inhibitor, the addition amount of the ginseng extract is 51-97%, and the addition amount of the radix sophorae flavescentis root extract is 3-49%. The collagenase inhibitor of the present invention has an excellent inhibiting effect on the activity of collagenase, and has no side effects on the human body.

The invention provides a collagenase inhibitor, a moisturizing crystal dew containing the collagenase inhibitor and a preparation method of the moisturizing crystal dew. The collagenase inhibitor comprises a dendrobium officinale extract and a chamomile extract, and based on the total mass of the collagenase inhibitor, the addition amount of the dendrobium officinale extract is 17-65%, and the addition amount of the chamomile extract is 35-83%. The collagenase inhibitor of the present invention has an excellent inhibitory effect on the activity of collagenase, and has no side effects on the human body.

The invention provides a moisturizing lotion, a collagenase inhibitor and a preparation method of the collagenase inhibitor. The moisturizing lotion comprises a collagenase inhibitor and a penetration enhancer, and the addition amount of the collagenase inhibitor is 0.01-10% based on the total mass of the moisturizing lotion; the addition amount of the penetration enhancer is 0.01-10% ; the collagenase inhibitor comprises a wild chrysanthemum flower extract and a chamomile extract, and based on the total mass of the collagenase inhibitor, the addition amount of the wild chrysanthemum flower extract is 27-74%, and the addition amount of the chamomile extract is 26-73%. The moisturizing lotion disclosed by the invention is mild in formula and can effectively improve skin elasticity, so that an anti-aging effect is achieved.

The invention discloses a vegetable cleanser and a preparation method thereof. The vegetable cleanser is prepared from the following components in parts by weight: 30 to 60 parts of flos lonicerae, 20to 50 parts of aloe, 20 to 30 parts of fructus gleditsiae abnormalis, 5 to 10 parts of lemon, 1 to 3 parts of sodium chloride, 1 to 3 parts of peppermint oil, 5 to 10 parts of tower gourd ladle, 2 to5 parts of collagenase inhibitor, 2 to 5 parts of elastase inhibitor, 2 to 10 parts of collagen and 300 to 500 parts of deionized water. The cleanser reduces irritation to the skin and has the efficacy of cleaning, disinfecting and sterilizing.