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31 results about "Calcium overload" patented technology
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Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
InactiveUS20080234257A1High crystallinityThe result is moreBiocideNervous disorderDiabetic retinopathyChemical synthesis
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, attention deficit hyperactivity disorder, fibromyalgia, irritable bowel syndrome, and / or premature ejaculation are described.
Owner:ACADIA PHARMA INC
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
Owner:ACADIA PHARMA INC
Prevention and treatment of cardiac conditions
InactiveUS20080275036A1Efficient treatment methodMinimizing undesirable side effectOrganic active ingredientsBiocideHeart diseaseEndocrinology
The present invention provides a method of treating conditions associated with iron and calcium overload comprising administering an effective amount of dexrazoxane or a non-dexrazoxane compound of formula (IA), (IB), or (IC) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.
Owner:APT PHARMA INC
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:ACADIA PHARMA INC
Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:ACADIA PHARMA INC
Pharmaceutical uses of NBC1 N-cyano amide sulfide inhibitor S0859
InactiveCN109288828AEasy to refactorRefactoring delayAmide active ingredientsCardiovascular disorderLeft Ventricle RemodelingPharmaceutical care
The present invention relates to pharmaceutical uses of a Na<+>-coupled HCO3< > transporter (NBC1) N-cyano amide sulfide inhibitor S0859, and provides uses of a Na<+>-coupled HCO3< > transporter (NBC1) N-cyano amide sulfide inhibitor S0859 in preparation of heart failure treating drugs. According to the present invention, the results prove that the inhibitor S0859 can regulate the intracellular calcium ion homeostasis after myocardial infarction, improve ventricular remodeling, and inhibit intracellular calcium overload so as to inhibit ventricular remodeling, such that the invention can provide a new heart failure treating drug so as to effectively delay heart failure and ventricular remodeling caused by myocardial infarction.
Owner:NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
Method of modulating activity of calcium channels in cardiac cells and reagents therefor
The present invention relates generally to novel peptides that are capable of modulating the activity of calcium channels in cardiac cells. More specifically, the present invention provides a method of modulating the activity of a cardiac calcium channel comprising contacting a cardiac ryanodine receptor (RyR2) with an amount of a fragment of a dihydropyridine receptor (DHPR) polypeptide sufficient to modulate the activity of said RyR2, and determining the activity of said calcium channel. The inventive method is useful for the treatment of a range of disorders and diseases associated with cardiac dysfunction, particularly those diseases and disorders involving reduced cardiac output and / or aberrant excitation-contraction coupling, calcium overload, or calcium leakage, in cardiac cells.
Owner:AUSTRALIEN NAT UNIV
Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
InactiveCN101360742AOrganic active ingredientsNervous disorderCompulsive disordersDiabetic retinopathy
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive- compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Application of GSPE (grape seed proanthocyanidin extract) in preparation of targeted drug for treating cell calcium overload injury
InactiveCN105412393ABlock inflowOverload damage reversalAntibacterial agentsCardiovascular disorderVascular endotheliumMortality rate
The invention discloses an application of GSPE (grape seed proanthocyanidin extract) in preparation of a targeted drug for treating cell calcium overload injury. The cell calcium overload injury means vascular endothelial cell calcium overload injury resulting in pyemia, the GSPE does not influence classic signal channels TLR4 and NFkB of LPS (lipopolysaccharide), Orail signals are specifically blocked, and calcium overload signals are blocked. The application indicates that the GSPE can effectively block activation of Orail mediated SOCE (store-operated calcium entry) by LPS, blocks extracellular calcium ion inflow initiated by the Orail mediated SOCE, reverses lung microvascular endothelial cell calcium overload injury of mice with pyemia and reduces the death rate of the mice with pyemia.
Owner:孙荣距
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Hydroxyapatite/saccharomycetes biological hybrid material as well as preparation method and application thereof
ActiveCN114159466AIncrease lethalityEnhanced overkillOrganic active ingredientsInorganic phosphorous active ingredientsTumor therapyEngineering
The invention discloses a hydroxyapatite / saccharomycetes biological hybrid material as well as a preparation method and application thereof, and relates to the field of tumor treatment, and the preparation method comprises the following steps: vibrating saccharomycetes in a liquid culture medium overnight, and dispersing in deionized water to obtain a saccharomycetes dispersion liquid; and respectively taking a Ca (NO3) 2 solution and an ammonium phosphate solution with the same volume, mixing, adding the yeast dispersion liquid, stirring, and centrifugally cleaning to obtain the HA / Yeast biological hybrid material. On the basis of the HA / Yeast biological hybrid material, tumor calcium overload and tumor immune collaborative treatment can be realized, and the problem that the tumor killing effect of a single way is relatively weak is solved. The HA / Yeast nano-particles disclosed by the invention are simple in synthesis method, good in dispersity and uniform in size; the yeast can achieve tumor specific targeting by tending to an acid environment, H2S is generated through fermentation to enhance tumor calcium overload, meanwhile, tumor immunotherapy is activated, and finally tumor synergistic killing is achieved.
Owner:ZHEJIANG UNIV
Use of a small native peptide activator of SERCA pump for treatment of heart failure and other disorders characterized by cytosolic calcium overload
The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
Owner:BOARD OF RGT THE UNIV OF TEXAS SYST
a h 2 o 2 Preparation method and application of self-supply calcium peroxide-loaded curcumin nanoparticles
ActiveCN112274495BThe preparation method is scientific and reasonableLow costPeroxide active ingredientsKetone active ingredientsCombined treatmentTumor cell apoptosis
Owner:ZHENGZHOU UNIV
Pyrazine derivative, and preparation method and medical use thereof
ActiveUS20190276413A1Improve protectionStrong free radical scavenging and cytoprotective effectsOrganic active ingredientsSenses disorderPyrazineDisease cause
The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.
Owner:GUANGZHOU MAGPIE PHARMA
Method of modulating the activity of calcium channels in cardiac cells and reagents therefor
InactiveUS20050049198A1High activityEnhance the activity of said RyR2Antibacterial agentsCompound screeningRyanodine receptorReceptor
The present invention relates generally to novel peptides that are capable of modulating the activity of calcium channels in cardiac cells. More specifically, the present invention provides a method of modulating the activity of a cardiac calcium channel comprising contacting a cardiac ryanodine receptor (RyR2) with an amount of a fragment of a dihydropyridine receptor (DHPR) polypeptide sufficient to modulate the activity of said RyR2, and determining the activity of said calcium channel. The inventive method is useful for the treatment of a range of disorders and diseases associated with cardiac dysfunction, particularly those diseases and disorders involving reduced cardiac output and / or aberrant excitation-contraction coupling, calcium overload, or calcium leakage, in cardiac cells.
Owner:AUSTRALIEN NAT UNIV
Application of snake-gourd-fruit and cinnamon-twig decoction to preparing of medicine for treating cerebral arterial thrombosis sequelae
InactiveCN105412897ARelieve symptomsFunction increaseNervous disorderCardiovascular disorderSequelaCranial nerves
The invention discloses an application of snake-gourd-fruit and cinnamon-twig decoction to preparing of medicine for treating cerebral arterial thrombosis sequelae. The application is characterized in that the dosage of radices trichosanthis in traditional snake-gourd-fruit and cinnamon-twig decoction is increased by 5 times to serve as a medicine formula, and the snake-gourd-fruit and cinnamon-twig decoction is used for preparing the medicine for treating cranial nerve injuries in the cerebral arterial thrombosis sequelae. According to the application, overloading of calcium in nerve injured cells of brain tissues is reversed mainly through the interaction between active ingredients in the radices trichosanthis and calcium-overloading-resisting medicine targets in the nerve injured cells of the brain tissues in cerebral arterial thrombosis so that the nerve injuries in the cerebral arterial thrombosis sequelae can be relieved, and the recovery effect is achieved.
Owner:FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Pyrazine derivative, and preparation method and medical use thereof
ActiveUS10703729B2Improve protectionStrong free radical scavenging and cytoprotective effectsOrganic active ingredientsSenses disorderPyrazinePharmacology
The present invention relates to a pyrazine derivative, and preparation method and medical use thereof. The pyrazine derivative can remove free radicals and suppress calcium overload and has cytoprotective effects, and can be used for the prevention and treatment of cardiovascular and cerebrovascular diseases, neurodegenerative diseases and other related diseases.
Owner:GUANGZHOU MAGPIE PHARMA
Photodynamic combined calcium overload nano-carrier and preparation method and application thereof
PendingCN113769110AImprove bindingPromote apoptosisPowder deliveryOrganic active ingredientsAptamerSurface marker
The invention relates to a photodynamic combined calcium overload nano-carrier and a preparation method and application thereof, and particularly discloses a tumor cell targeted anti-tumor nano-carrier. The tumor cell targeted anti-tumor nano-carrier is characterized in that the nano-carrier comprises calcium peroxide particles, black phosphorus quantum dots are electrostatically adsorbed on the surfaces of the calcium peroxide particles. The calcium peroxide particles adsorbed with the black phosphorus quantum dots are wrapped by a polymer to form nanoparticles, and the polymer is coupled with a modifier of a targeted tumor surface marker; the modifier is selected from an antibody, folic acid, polypeptide and an aptamer of the targeted tumor surface marker. According to the photodynamic combined calcium overload nano-carrier and the preparation method and application thereof, the nano-carrier can promote apoptosis of tumor cells with high expression of GPC3 or inhibit proliferation of the tumor cells, can be used as a biological nano-drug of a GPC3 binding site, and can be used for preparing a drug for preventing and / or treating liver cancer.
Owner:SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
Multistage response injectable hydrogel loaded with gambogic acid and application thereof
ActiveCN114767620AGood injectabilityImprove mechanical propertiesOrganic active ingredientsInorganic phosphorous active ingredientsSide effectGambogic acid
The invention provides a hydrogel precursor and hydrogel formed by curing the hydrogel precursor. The hydrogel precursor comprises the following components: 0.3-0.8 mg / mL of gambogic acid lipidosome; 3 to 8 mg / mL of fibrinogen; 3 to 8 NIHU / mL of thrombin; calcium hydrogen phosphate is 15 to 25 [mu] mol / mL; and the balance of water. The precursor has good injectable performance, hydrogel can be formed through physiological response solidification after local injection at a tumor site, in a tumor acid environment, medicine gambogic acid and calcium ions are released after a hydrogel skeleton containing calcium hydrophosphate is hydrolyzed, on one hand, gambogic acid has an anti-tumor effect, and on the other hand, the calcium ions can be released through calcium ions; on the other hand, hydrolyzed calcium ions can be promoted to enter tumor cells, calcium overload in the tumor cells is caused, apoptosis is caused, and therefore the synergistic effect is achieved for treating tumors. The hydrogel disclosed by the invention can improve the drug concentration of a tumor part through local in-situ injection, and is small in toxic and side effects, excellent in anti-tumor effect and good in clinical application prospect.
Owner:SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL
Preparation method of H2O2 self-supply type calcium peroxide loaded curcumin nanoparticles and application thereof
ActiveCN112274495AThe preparation method is scientific and reasonableLow costPeroxide active ingredientsKetone active ingredientsCombined treatmentTumor cell apoptosis
The invention relates to a preparation method and an application of H2O2 self-supply type calcium peroxide loaded curcumin nanoparticles, which can effectively solve the problems of preparation of theH2O2 self-supply type calcium peroxide loaded curcumin nanoparticles, calcium overload aiming at tumors, chemotherapy, chemodynamic therapy and drug use for promoting tumor cell apoptosis, the particle size of calcium peroxide is 50-100nm, the pore diameter is 5-8nm, transferrin is loaded in holes of calcium peroxide through electrostatic adsorption, the transferrin is positively charged, the mass ratio of the calcium peroxide to the transferrin is 3-5: 1, and then a micromolecular antitumor drug curcumin is loaded on the surface of the transferrin through electrostatic adsorption, so that H2O2 self-supplied calcium peroxide loaded curcumin nanoparticles with the drug loading weight of 30%-55% and the particle size of 55-105 nm are obtained. The preparation method disclosed by the invention is scientific, reasonable, stable, reliable and low in cost, and the prepared H2O2 self-supplied calcium peroxide loaded curcumin nanoparticles can play a role in triple strike interaction comprehensive treatment of tumors in the aspect of preparation of anti-tumor drugs, so that the anti-tumor effect is enhanced.
Owner:ZHENGZHOU UNIV
Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity
Owner:AUSPEX PHARMA INC
Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity
InactiveCN101360698ANervous disorderIsotope introduction to organic compoundsChemical synthesisDiabetic retinopathy
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described in Formula (I).
Owner:AUSPEX PHARMA INC
Application of sterides in preparing medicament for treating cardiovascular and cerebrovascular diseases
InactiveCN101172111AEasy to relaxImprove protectionOrganic active ingredientsSolution deliveryVasodilationCardiac muscle
The present invention provides an application of a steroid compound in the preparation of a drug for treating cardiovascular and cerebrovascular diseases, wherein the structure of the steroid compound is as follows: the drug prepared by the application of the present invention has the effect of promoting vasodilation and inhibiting cardiomyocytes induced by KCl The protective effect of internal calcium overload can treat cardiovascular and cerebrovascular diseases.
Owner:JINAN UNIVERSITY
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and / or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoricdisorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and / or premature ejaculation are described.
Owner:AUSPEX PHARMA INC
Application of sterides in preparing medicament for treating cardiovascular and cerebrovascular diseases
InactiveCN101172111BEasy to relaxImprove protectionOrganic active ingredientsSolution deliveryDiseaseVasodilation
The invention provides the application of steroidal compound during the process of preparing the medicine for remedying heart-and-brain vein disease, wherein, the steroidal compound has the followingstructures that the medicine prepared by the application of the invention has the function of stimulating vasodilatation and the protection function to calcium overload in the cardiac muscle cell induced by KC1, and heart-and-brain vein diseases can be remedied.
Owner:JINAN UNIVERSITY
Marker for calcium overload mediated neuron death and application
Owner:CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
ActiveUS20150152042A1High crystallinityTrend downBiocideNervous disorderDiseaseIrritable bowel syndrome
Owner:ACADIA PHARMA INC
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