65 results about "Arterial aneurysms" patented technology

A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.

Stent and stent delivery system suited for the noninvasive treatment of aneurysms, diseased blood vessels, and other bodily lumen are described. Detachable proximal and / or distal wires connected to the proximal and distal ends, respectively, of the stent allow the operator to manipulate the position and final configuration of the stent upon deployment.

Apparatus for treating an aneurysm in a vessel that isolates a volume around the aneurysm, evacuates that volume and heats the aneurysmal wall. A catheter includes one or more inflatable balloons for defining the isolated volume and occluding and preventing any blood flow through the volume. Suction applied through the catheter to the isolated volume withdraws any blood in the isolated volume and displaces the tissue for contact with a thermal source that heats the aneurysmal wall. When the treatment is completed, the balloons are deflated and the catheter is removed from the vessel.

A stent graft extends in a flow lumen to span a defective portion of the flow lumen and seal the defective portion from further blood contact. The stent graft includes a pair of apertures, from which extensions project into the renal arteries to seal the passage of blood into the renal arteries from the abnormality. The apertures are larger than the opening of the renal arteries, such that the apertures need not be centered with the renal arteries to enable placement of the extensions. The aperture opening and side branch extensions contain hook and loop structures to provide a variably positionable seal of the aperture opening.

Universal endovascular grafts are provided for evaluation and repair of damaged or aneurismal blood vessels. More particularly, the present invention relates to universal fenestrated and universal branched endografts for repair of blood vessels with branches, methods for implanting the endografts in the vessel and for making connection with one or more branches. The universal fenestrated endografts have a body with a first end, a second end, a first wall, a second wall, and an interior passage or lumen. The body further includes openings in communication with the passage at the first and second ends and one or more lateral fenestrations in communication with the lumen. The body further has a necked portion between the ends and a cannulation member. The universal branched endografts have a tubular body with a main lumen and four branch lumens. A large branch extends from the body. The four lumens are positioned about a circumference of the tubular body.

The invention discloses a method for preparing brain tissue and vascular entity composite model based on MRI (magnetic resonance imaging) and CTA (CT angiography). The method includes: 1), acquiring image data of head and neck skull, brain tissue, vessel and arterial aneurysm; 2), leading acquired MRI and CTA original image data into three-dimensional reconstruction software, structuring a 3D composite virtual model containing the skull, brain tissue, vessel and arterial aneurysm and outputting to a 3D printer for 3D model printing in a format that the 3D printer can print to acquire the three-dimensional entity composite model containing the skull, brain tissue, vessel and arterial aneurysm. The model is quite high in simulation degree, so that doctors can perform preoperative discussionof surgical planning, preoperative risk assessment and design of operative route or even simulate operation in combination with the model; the brain tissue model is of fluid silicone brain tissue thatcan be pulled apart and can be pulled apart as in actual operation, so that the doctors are more confident, and operation risks are lowered.

Methods and compositions are provided which contains preparations of calcium chelators, bisphosphonates, antibiotics, antimicrobial agents, cytostatic agents, calcium ATPase and pyrophosphatase pump inhibitors, calcium phosphate-crystal dissolving agents, agents effective against calcium phosphate-crystal nucleation and crystal growth, and / or a combination of supportive agents and which may be used for treating and or reducing pathological calcifications, the growth of Nanobacterium and calcification-induced diseases including, but not limited to, Arteriosclerosis, Atherosclerosis, Coronary Heart Disease, Chronic Heart Failure, Valve Calcifications, Arterial Aneurysms, Calcific Aortic Stenosis, Transient Cerebral Ischemia, Stroke, Peripheral Vascular Disease, Vascular Thrombosis, Dental Plaque, Gum Disease (dental pulp stones), Salivary Gland Stones, Chronic Infection Syndromes such as Chronic Fatigue Syndrome, Kidney and Bladder Stones, Gall Stones, Pancreas and Bowel Diseases (such as Pancreatic Duct Stones, Crohn's Disease, Colitis Ulcerosa), Liver Diseases (such as Liver Cirrhosis, Liver Cysts), Testicular Microliths, Chronic Calculous Prostatitis, Prostate Calcification, Calcification in Hemodialysis Patients, Malacoplakia, Autoimmune Diseases. Erythematosus, Scleroderma, Dermatomyositis, Antiphospholipid Syndrome, Arteritis Nodosa, Thrombocytopenia, Hemolytic Anemia, Myelitis, Livedo Reticularis, Chorea, Migraine, Juvenile Dermatomyositis, Grave's Disease, Hypothyreoidism, Type 1 Diabetes Mellitus, Addison's Disease, Hypopituitarism, Placental and Fetal Disorders, Polycystic Kidney Disease, Glomerulopathies, Eye Diseases (such as Corneal Calcifications, Cataracts, Macular Degeneration and Retinal Vasculature-derived Processes and other Retinal Degenerations, Retinal Nerve Degeneration, Retinitis, and Iritis), Ear Diseases (such as Otosclerosis, Degeneration of Otoliths and Symptoms from the Vestibular Organ and Inner Ear (Vertigo and Tinnitus)), Thyroglossal Cysts, Thyroid Cysts, Ovarian Cysts, Cancer (such as Meningiomas, Breast Cancer, Prostate Cancer, Thyroid Cancer, Serous Ovarian Adenocarcinoma), Skin Diseases (such as Calcinosis Cutis, Calciphylaxis, Psoriasis, Eczema, Lichen Ruber Planus), Rheumatoid Arthritis, Calcific Tenditis, Osteoarthritis, Fibromyalgia, Bone Spurs, Diffuse Interstitial Skeletal Hyperostosis, Intracranial Calcifications (such as Degenerative Disease Processes and Dementia), Erythrocyte-Related Diseases involving Anemia, Intraerythrocytic Nanobacterial Infection and Splenic Calcifications, Chronic Obstructive Pulmonary Disease, Broncholiths, Bronchial Stones, Neuropathy, Calcification and Encrustations of Implants, Mixed Calcified Biofilms, and Myelodegenerative Disorders (such as Multiple Sclerosis, Lou Gehrig's and Alzheimer's Disease) in humans and animals. The method comprises administering the various classes of compositions of the present invention, which together effectively inhibit or treat the development of calcifications in vivo.

The invention discloses an intravascular stent with complex functions. The intravascular stent comprises a stent main body which is mesh-shaped and can be released from and retracted to a feeding catheter, wherein a near end of the stent main body is openly conical, the middle part of the stent main body is circular tube-shaped, and a far end of the stent main body has a closed structure; and the stent main body has a mesh shape which is woven by single wires or a plurality of wires or is engraved by a laser engraving machine. The stent which is taken as an acute thrombus removal system can quickly and efficiently take out thrombi, and can also capture small thrombi which flow toward the far end so as to avoid secondary stroke caused by the thrombus blockage of the far end; the stent which is taken as a temporary stent expands intracranial blood vessels or narrow and blocked blood vessels on other parts of human bodies, plays the effects of dredging and reconstructing blood flow, and can capture small thrombi or emboli; and the stent which is taken as a long-term implanted stent performs adjuvant therapy on arterial aneurysms of furcations, and fills in a market gap. If the position of the stent is not satisfactory, the entire stent can be retracted to the feeding catheter, and is released again. The maneuverability of the stent is high, so the operation difficulty is reduced, and the surgical success rate is greatly improved.

A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.

The invention provides a simulation method and device for intracranial aneurysm treatment. The method comprises the following steps: establishing a three-dimensional structure of a spring ring and placing the spring ring into an arterial aneurysm: packaging the spring ring into a simulated catheter in a simulated calculation manner and then releasing the spring ring into the arterial aneurysm; establishing a three-dimensional structure of a stent and placing the stent into an arterial aneurysm carrying blood vessel: compressing and placing the stent into a micro catheter in a simulated calculation manner, then bending the stent and the micro catheter, and releasing the stent into the arterial aneurysm carrying blood vessel; establishing a structure of the spring ring, and when the spring ring is placed in the arterial aneurysm, simulating the spring ring into a three-dimensional Euler-Bernoulli beam; establishing a three-dimensional structure of the stent, and when the stent is placed in the arterial aneurysm carrying blood vessel, simulating the stent into a three-dimensional shell unit; when the stent is released into the arterial aneurysm carrying blood vessel, bending the stent and the micro catheter along the central line of the arterial aneurysm carrying blood vessel. The device is used for implementing the simulation method. According to the simulation method and the device, the simulation calculation efficiency can be improved, and the calculation time is shortened.

The invention relates to a circular bilateral Gabor filtering and local gradient analysis based automatic detection method for a microaneurysm in a color eye fundus image. The method comprises: firstly, preprocessing a green channel of the color eye fundus image; secondly, extracting candidates by adopting circular bilateral filtering and performing threshold segmentation to remove main blood vessels; and finally, calculating a local gradient direction histogram, removing tiny blood vessels according to the gradient direction anisotropy of the microaneurysm, calculating local contrast and roundness, and filtering out noises and bleeding points, thereby realizing the automatic detection of the microaneurysm. According to the method, the gray-level and structure information of the microaneurysm and the local gray-level difference of the tiny blood vessels are utilized, so that the influences of non-uniform illumination, low contrast and the tiny blood vessels can be overcome; the method not only can accurately detect large-sized, high-contrast and single-background microaneurysms but also has a very good detection effect on small-sized and low-contrast microaneurysms with complicated backgrounds close to blood vessels, yellow spots and the like; and finally the automatic detection of the microaneurysm is realized.

The present invention relates to decellularized vascular prostheses that are resistant to thrombus occlusion and have a low level of immunogenicity. The vascular prostheses are denuded of cells, and coated with an anti-thrombogenic agent and a growth factor that promotes recellularization and further reduces the immunogenicity. The prostheses have high mechanical strength, resist aneurysm rupture, and allow for secure surgical sutures while maintaining structural integrity. The present invention provides vascular prostheses that are blood vessels, valves or portions of vessels containing valves. The present invention is also useful for coating synthetic vascular stents.

The invention relates to a rapid capture device of a three-dimensional structure. Compared with an existing two-dimensional plane loop capture device, the three-dimensional rapid capture device has the advantages that due to the fact that the three-dimensional structural design is adopted, the space where capture can be conducted is greatly expanded and a leap from the two-dimensional plane to the three-dimensional structure is achieved. The three-dimensional rapid capture device comprises a handle, a capture rod and a capture sleeve. One end of the capture rod is connected with the handle and the other end of the capture rod is connected with the capture sleeve. The capture sleeve comprises at least three spiral capture wires, wherein the two ends of each capture wire are connected with the two ends of another capture wire respectively. When the capture sleeve is used, the capture wires face one another and are expanded in a spiral mode, so that a three-dimensional network space is formed. The three-dimensional rapid capture device is applied to a congenital heart disease cardiac transcatheter closure operation and other transcatheter interventional therapy (such as an arterial aneurysm operation) and is used for rapidly capturing guidewires to establish a conveying track.

The invention relates to a multi-channel membrane-coated intravascular stent and a preparation method thereof. A multi-channel intravascular stent is coated with a membrane and comprises a stent body, wherein the surface of the stent body is coated with a polytetrafluoroethylene membrane; the polytetrafluoroethylene membrane is prepared by electrospinning the surface of the stent body with a polytetrafluoroethylene solution; the polytetrafluoroethylene solution comprises polytetrafluoroethylene and perfluor-paraffin; and the concentration of the polytetrafluoroethylene is 1-30g / ml. Compared with the prior art, the polytetrafluoroethylene layer clads the surface of the stent body; the performance of the coating is similar to that of expanded polytetrafluoroethylene; and the coating can be processed into various shapes such as barrels, circles and curved surfaces, thus the multi-channel intravascular stent is suitable for complicated arterial aneurysm treatment; and the achievement ratio of an operation is improved.

The present invention relates to an endoprosthesis composed of (a) two complementary bodies, body “A” and (b) a body “B”, with the said bodies being formed by proximal, intermediate and distal regions and comprising a self-expanding structure of resistant and flexible material and a graft wherein the said bodies “A” and “B” have a bifurcation for use where a main vessel bifurcates into at least two secondary branches, such as in the case of the treatment of aneurysms in the abdominal aorta.The invention further includes a delivery system for the endoprosthesis of the present invention, as well as its use in the treatment of aneurysms.

The invention discloses an intravascular multilayer bare stent system, and relates to the technical field of medical equipment. According to the technical points, a support body is composed of a firstframework and a second framework, and the first framework and the second framework are of a cylindrical net structure formed by weaving framework lines made of memory alloy or biodegradable polymer materials, overlapped with each other and opposite in spiral rotation direction. Rotary connecting rings are arranged at the upper sections, the middle sections and the lower sections of the first framework and the second framework; metal wires are connected to the inner wall of the rotary connecting ring; a hole-sealing strip-shaped film is connected to the side wall of the metal wire. The mesh sealing of the multilayer bare stent can be adjusted, so that the aneurysm cavity and the interlayer are isolated from normal blood flow, normal blood flow is prevented from leaking into the aneurysm cavity and the interlayer, blood flow in the aneurysm cavity and the interlayer is restrained, blood clots or thrombi are promoted to be formed in the aneurysm cavity and the interlayer to atrophy the aneurysm, the pressure in the aneurysm cavity is reduced, the potential risk that the aneurysm is increased and ruptured is reduced, and stable and guaranteed treatment purpose is achieved.

A hydrogel based occlusion system, a method for occluding vessels, appendages or aneurysms, and a method for hydrogel synthesis are disclosed. The hydrogel based occlusion system includes a hydrogel having a shrunken and a swollen state and a delivery tool configured to deliver the hydrogel to a target occlusion location. The hydrogel is configured to permanently occlude the target occlusion location in the swollen state. The hydrogel may be an electro-activated hydrogel (EAH) which could be electro-activated with a delivery system to control the degree of swelling / shrinking.

The invention relates to a multi-channel covered vascular stent and a preparation method thereof, wherein the multi-channel covered vascular stent comprises a stent body, and a polytetrafluoroethylene film is covered on the surface of the stent body. Compared with the prior art, the polytetrafluoroethylene film is covered on the surface of the stent body of the multi-channel covered vascular stent, the performance of the covered film is similar to that of expanded polytetrafluoroethylene and can be processed into a variety of shapes, such as a cylinder, a circle and a curved surface, so that the multi-channel covered vascular stent is suitable for treating complicated arterial aneurysm, and the success rate of surgery is improved.

A mechanism for guiding and / or releasing an endoprosthesis at a blood vessel lesion region, used in a medical device of the type of a catheter, represents an inventive solution in the field of medicine, being particularly useful for the treatment of vascular diseases, in particular for specific pathologies such as aneurysms and aortic dissections, the invention being used in a medical device of the type of a catheter (1), it being possible to remove the entire endoprosthesis (17), which was ergonomically improved in the way in which it is guided and handled when mounted together with this catheter (1), including structural and operational improvements to the mechanism for fastening and releasing the distal portion of the endoprosthesis, and also to the mechanism for fastening and releasing the proximal portion of the endoprosthesis, achieving a distinct final quality of the application of the endoprosthesis.

The invention discloses a partial covering film vascular stent. The partial covering film vascular stent comprises a bare stent body and a covering film. The bare stent body is partially covered with the covering film, wherein the covering film accounts for 1 / 2 to 3 / 4 of the circumferential surface area the bare stent body. At least one first X-ray-impermeable marking point is arranged on the middle horizontal line of the covering film. At least two second X-ray-impermeable marking points are arranged on the left edge or the right edge or the upper edge or the lower edge of the covering film. According to the partial covering film vascular stent, the covering film is arranged on the bare stent body in a longitudinally covering mode, an X-ray-impermeable marking point is arranged in the middle of the covering film on the bare stent body, two X-ray-impermeable marking points are arranged on the edge of the covering film, so that the position of releasing the stent is determined, and it is guaranteed that an arterial aneurysm is covered with the covering film side after the stent is released and a branch blood vessel is not covered with the bare stent body.

The embodiment of the invention discloses a thrombus attribute information obtaining method, device and equipment and a storage medium. The method comprises the steps: constructing an original supportmodel and an original arterial aneurysm model according to a support parameter of a dense net support and a target three-dimensional image; determining a target arterial aneurysm model according to the original support model and the original arterial aneurysm model after the dense net support is placed; performing the computational fluid mechanics simulation based on the target arterial aneurysmmodel according to a preset thrombus forming process, and obtaining a target simulation result; and determining the thrombus attribute information corresponding to the dense net support and the targetthree-dimensional image according to the target simulation result. Through the above technical scheme of the invention, the method achieves the obtaining of the thrombus attribute information after arterial aneurysms of patients are placed on different dense net supports before operation, thereby providing more precise data support for the clinical treatment of the intracranial aneurysm.

The invention relates to an intracranial aneurysm blood flow guide support. The guide support comprises a main body part and an encryption part, wherein the main body part is of a cylindrical structure which is formed by weaving stent wires manually or by a weaving machine and is provided with an overlapping part through curling and shaping, the encryption part is arranged at the overlapping partfor mesh encryption, and the overlapping part and the encryption part cover an aneurysm opening. By means of the structural design, normal blood circulation of nearby side branch blood vessels is keptwhile blood flowing into the aneurysm is blocked, and in addition, due to the fact that axial stretching and retracting are reduced when the stent is pressed and held, the release difficulty is lowered.

The invention relates to an aneurysm plugging device, which comprises a supporting part and a plugging part. The supporting part comprises a supporting frame, and the diameter of the bottom end of the supporting frame is smaller than the maximum diameter of the supporting frame; the plugging part comprises a framework, and the framework is fixed to the bottom end of the supporting frame. Compared with an existing spring ring packing method, the blood can be immediately prevented from entering the aneurysm, the effects of improving hemodynamic force at the aneurysm neck and promoting aneurysm healing are achieved, and treatment of ruptured aneurysm is particularly facilitated. Compared with an existing dense net stent or covered stent intervention method, the method only aims at covering the arterial aneurysm neck opening, the blood flow of collateral vessels is not affected, and the problem of local ischemia caused by the dense net stent or covered stent intervention method is solved.

The invention generally relates to co-axial stent and catheter systems and medical procedures utilizing these systems. The co-axial stent system is characterized by two-coaxial stents, including an outer resorbable stent and an inner metal stent used to effect deployment of the resorbable stent. The stents may use for treatment of unstable plaque and / or thrombus at the carotid bifurcation and particularly those that are not causing any significant stenosis. The stents may also be used for treatment of cerebral aneurysms. The invention further describes related, equipment, uses and kits for the treatment of unstable plaque and / or thrombus and / or aneurysms.

The invention relates to an embedded type intelligent controllable blood vessel locking device. The embedded type intelligent controllable blood vessel locking device comprises a shell, an actuator and a control module, wherein the shell accommodates the blood vessel and carries the actuator and the control module; the control module provides electric energy and a control signal for the actuator;the actuator comprises a fixed part, an electrical activity polymer material and a movable part, after electrifying, the electrical activity polymer material deforms and drives the movable part to move, the blood vessel accommodated in the shell is squeezed, so that the blood vessel is gradually locked. The embedded type intelligent controllable blood vessel locking device is designed aiming at the demand of treating intracranial aneurysm, basicranial tumor or other brain diseases, and the defects in the existing methods that lesion blood-supply internal carotid is blocked in advance before treatment. The embedded type intelligent controllable blood vessel locking device can be completely implanted in the body, wrap the blood vessel, and slowly lock the internal carotid in a controlled manner, so that the blood-supply brain tissue of internal carotid can obtain compensatory blood supply of other blood vessels, the dependence on the artery is eliminated, then the internal carotid is cutoff, so that cerebral infarction can not be caused, and conditions are created for disease treatment.

Aneurysms are classified and quantitatively analyzed based on medical image data acquired from a subject. In general, one or more algorithms are implemented to automatically classify, or otherwise diagnose, and measure aneurysms and their change over time. These algorithms make use of artificial intelligence and deep learning to develop quantitative analytics that can be consolidated into diagnostic reports.

The invention relates to the field of medical instruments, in particular to an aneurysm plugging device and a preparation method thereof. The aneurysm plugging device comprises a plugging device body of a net-shaped woven structure. A first binding part and a second binding part are formed at the two ends of the net-shaped woven structure respectively. The free end of at least one woven tow in the first binding part and the second binding part faces the interior of the net-shaped woven structure. The aneurysm plugging device is further provided with a far-end developing mark and a near-end developing mark, and the far-end developing mark and the near-end developing mark are arranged on the first binding part and the second binding part respectively. The aneurysm plugging device is high in metal coverage rate, can effectively reduce compression of an implantation device on aneurysm and interference of the implantation device on blood flow in a tumor cavity, and is beneficial to rapid endothelialization of cells.