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32 results about "5alpha-reductase" patented technology
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Osmanthus fragrans polyphenol extract product, and preparation method and uses thereof
ActiveCN103223018AWide variety of sourcesClear compositionUrinary disorderAntineoplastic agentsLiquid ratioPolyphenol
The invention relates to a plant polyphenol extract product extracted from Osmanthus fragrans, and a preparation method and uses thereof, and concretely discloses an Osmanthus fragrans polyphenol extract product preparation method. The method comprises the following steps: 1, mixing Osmanthus fragrans with an aqueous solution of an extracting agent according to a solid / liquid ratio of 1g / 15-60ml, carrying out microwave extraction of the obtained mixture under a pressure of 200-500KPa and a power of 80-200W for 3-20min, and repeating the above extraction process; and 2, mixing obtained filtrates to obtain a filtrate mixture, and drying the filtrate mixture to obtain an Osmanthus fragrans polyphenol extract product. The Osmanthus fragrans polyphenol extract product can be used for preparing antitumor medicines or healthcare products, and can also be used for inhibiting the activities of 5alpha-reductase.
Owner:ZHEJIANG UNIV
Medicinal composition containing insoluble medicament
InactiveCN102145003AAvoid degradationAvoid Absorption IrregularitiesUrinary disorderAmide active ingredientsPoor complianceSide effect
The invention discloses a medicinal composition containing an insoluble alpha-receptor retardant and / or 5alpha-reductase inhibitor with an effective dose, which comprises the following components of: principal ingredients, a substrate, a solubilizer, a sorbefacient and an additive in a weight ratio of 1:(8-7,000):(0-460):(0-150):(0-150), wherein the medicinal composition at least contains one of the solubilizer and the sorbefacient. The effective dose of the insoluble alpha-receptor retardant and / or the 5alpha-reductase inhibitor is in 0.05 to 80 milligrams of parent compounds of the insoluble alpha-receptor retardant and / or the 5alpha-reductase inhibitor, the weight of a preparation per unit is between 0.8 and 4.2 grams. The medicinal composition can be subjected to oral administration or rectum administration, so the defects of poor curative effect and large toxic and side effect in the conventional oral administration and systemic administration of injection and large side effect and poor compliance of patients in local injection administration can be overcome, the lasting time of the medicinal effect can be increased, and better treatment means can be provided for medical care personnel and patients; and a product process is simple and is suitable for industrial batch production.
Owner:张立英
Oil control and acne removal composition and application thereof
ActiveCN107126379AThe solution is not easy to cleanEasy to solveAntibacterial agentsCosmetic preparationsOil and greaseCinnamomum zeylanicum Bark Extract
The invention relates to an oil control and acne removal composition and an application thereof. The oil control and acne removal composition comprises, by weight, 2-25 parts of water-soluble polyurethane, 5-25 parts of kaolin, 1-5 parts of titanium dioxide, 3-10 parts of dipropylene glycol, 0.1-1 part of zinc pyrrolidone carboxylate and 1-5 parts of an anti-acne active substance. A polyurethane-containing mud film is produced by adopting the aqueous polyurethane as a film forming component and selecting the dipropylene glycol as a film forming assistant, the kaolin controls oil through externally adsorbing the oil, and octanoylglycine, sarcosine, Cinnamomum zeylanicum bark extract and zinc salt of strong acid of pyrrolidone can inhibit the oil secretion through inhibiting 5alpha-reductase, so the composition can effectively inhibit acne propionibacteria of acne skins and effectively restore acnes on oily skins.
Owner:HUNAN YUJIA COSMETICS MFG CO LTD
United medicinal composition used for treating urogenital system and lower urinary tract diseases
The invention relates to the field of urogenital system and lower urinary tract diseases. The invention provides a new medicinal composition. The composition comprises medicinal effective compositionof the following substances: I) a first compound selected from medicaments for treating bladder hyperactivity such as muscarinic receptor antagonist and medicaments for treating prostate hyperplasia such as 5alpha-reductase inhibitor and alpha-adrenergic receptor antagonist, precursors thereof and pharmacologically acceptable salts thereof, II) a second compound selected from PDE-5 enzyme antagonist, precursor thereof and pharmacologically acceptable salt thereof, and III) a second compound selected from antidiuretic, precursor thereof and pharmacologically acceptable salt thereof, and optional pharmacologically acceptable vector thereof or diluent. The three medicaments can be combined two by two (such as I + II, or I + III, or II + III), or combined together at the same time (such as I +II + III). The invention also provides a group of methods for treating urogenital system and lower urinary tract diseases of mammals comprising people, wherein the methods comprise applying treatmenteffective dose of the composition to the mammals comprising people needing the treatment.
Owner:许洁
Method of treating men with testosterone supplement and 5alpha-reductase inhibitor
InactiveUS20090123571A1Minimizes unpleasantMinimizes potentially dangerous side effectBiocideOrganic active ingredientsDiseaseAviptadil
A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.
Owner:MERCK SHARP & DOHME CORP
5alpha-reductase urtica open-loop lignan glycoside D inhibitor, preparation method thereof and use thereof
InactiveCN101717419AStrong operationSimple methodOrganic active ingredientsSugar derivativesDiseaseChromatographic separation
The invention discloses an urtica open-loop lignan glycoside D serving as a 5alpha-reductase inhibitor, a preparation method thereof and use thereof. The urtica open-loop lignan glycoside D is prepared by using the underground part of urtica triangularis as a raw material, extracting the raw material with alcohol, mixing an alcohol extract with hot water to obtain a suspension, extracting the extract with petroleum ether, ethyl acetate and water-saturated n-butyl alcohol, separating the extract from a raffinate water layer with macroporous resin, eluting the extract and separating and purifying the extract by silica gel column chromatography. The urtica open-loop lignan glycoside D can obviously inhibit the generation of DHT and has the potential to be used to prevent and treat prostate diseases like finasteride which is a masculine medicament. The open-loop lignan glycoside raw material is pure natural vegetable roots and safe and readily available. The method is simple and easy to operate and avoids introducing toxic materials. The urtica open-loop lignan glycoside D is low in cost, has a remarkable effect in spite of a vegetable source and has a great significance for the researches on and development of anti-benign prostatic hyperplasia medicaments.
Owner:DALIAN UNIVERSITY
Anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and preparation method of compound
ActiveCN103446563AEasy to makeReduce manufacturing costCosmetic preparationsHair cosmeticsSerenoa repens extract5alpha-reductase
The invention discloses an anti-hair-loss Chinese herbal medicine compound for inhibiting activity of 5alpha-reductase, and belongs to a pharmaceutical composition. The anti-hair-loss Chinese herbal medicine compound comprises a serenoa repens extract, a bayberry bark extract, a platycladus orientalis extract, an angelica sinensis extract, a rhizome anemarrhenae extract, a common selfheal fruit-spike extract, a ginger extract, a sophora flavescens extract, a jackfruit extract, a fructus schizandrae extract and a rhizome kaempferiae extract, wherein the percentage weight of all the extracts is 0.1-99% of the total amount of the anti-hair-loss Chinese herbal medicine compound. The anti-hair-loss Chinese herbal medicine compound is used for treating alopecia seborrheica symptom caused due to male androgenetic alopecia.
Owner:GUANGZHOU TIANWEN JIAOYAN COSMETICS
Epristeride slow release preparation
ActiveCN1899290ALittle side effectsReduce dosing frequencyOrganic active ingredientsUrinary disorderSolvent5alpha-reductase
The present invention provides a kind of slow released epristeride preparation as 5alpha-reductase inhibiter for treating benign hyperplasia of prostate. The slow released epristeride preparation consists of epristeride 10-30 wt%, slow releasing supplementary material 30-60 wt%, and other supplementary material for the rest. The slow releasing supplementary material is hydropropyl methyl cellulose, ethyl cellulose, polyacrylate resin and / or polyhydroxy ethylene. The other supplementary material includes pore creating agent, filler, adhesive, lubricant, wetting agent, solvent and / or filming agent. The slow released epristeride preparation can maintain the blood medicine level for 24 hr and high curative effect.
Owner:JIANGSU LIANHUAN PHARMA
Medicinal composition and application thereof
ActiveCN101879156AInhibitory activityInhibition of secretionAntipyreticAnalgesicsAromataseCyclooxygenase
The invention discloses a medicinal composition, which comprises two or three of a, b and c, wherein a is long-chain fatty acid compounds of a formula I or plant extract containing the same; b is flavonoid compounds of a formula II or plant extract containing the same; and c is the following alkaloid compounds or plant extract containing the same: N1,N5,N10-tri-(E / Z)-coumaroyl spermidine, 1-O-(beta-D-glucose)-(2S, 3S, 4R)-2N-[(2'R)-2'-hydroxytetracosenoicacid]-octadecylene-3,4-diol, putrescine and indol-3-acetic acid. The medicinal composition of the invention can be used for preparing aromatizing enzyme inhibitor, 5alpha reductase inhibitor, alpha1-adrenergic receptor antagonist, cyclooxygenase-2 inhibitor, prostate-specific antigen (PSA) secretion inhibitor, anti-inflammation medicamentor medicament for resisting prostatic hyperplasia, prostatitis or prostatic cancer.
Owner:JIANGSU KANION PHARMA CO LTD +1
New medicinal use of Chinese medicine nutmeg and its extract
ActiveCN1846775AGood treatment effectSignificant effectUrinary disorderPlant ingredientsCurative effectProstate hyperplasia
The present invention relates to new medicinal use of Chinese medicine nutmeg and its extract. Specifically, nutmeg and its extract is used in preparing 5alpha-reductase inhibitor and prostatic hyperplasia treating medicine with obvious curative effect, low cost and convenient use.
Owner:CHENGDU DIAO PHARMA GROUP
Hair growth agent composition
Disclosed herein is a composition for promoting hair growth. The composition comprises an Asiasari Radix extract as an active ingredient wherein the Asiasari Radix extract exhibits superior induction of the anagen phase of the hair growth cycle. The composition exhibits excellent hair loss prevention and hair growth promoting effects. In particular, when the composition further comprises an inhibitor of 5alpha-reductase activity and an activator of hair follicle cells, it exhibits better hair loss prevention and hair growth promoting effects.
Owner:LG HOUSEHOLD & HEALTH CARE LTD
Pharmaceutical composition comprising 5alpha-reductase inhibitor
InactiveUS20180207146A1Reduce stimulationComposition is stableOrganic active ingredientsDispersion deliveryIrritationAldose reductase inhibitor
Disclosed is a composition comprising a 5α-reductase inhibitor. Forming a liquid crystal upon exposure to an aqueous fluid, the composition can release the 5α-reductase inhibitor at a constant rate over a long period of time. In addition, the composition can significantly alleviate irritations attributed to the topical administration of the 5α-reductase inhibitor, and thus the composition has improved safety.
Owner:CHONG KUN DANG PHARMA CORP
Traditional Chinese medicine composition capable of inhibiting activity of 5alpha-reductase and application of traditional Chinese medicine composition to hair loss prevention cosmetics
InactiveCN102697681AInhibition of 5α-reductase activityInhibit synthesisCosmetic preparationsHair cosmeticsSophora RootAndrogen
The invention discloses a traditional Chinese medicine composition capable of inhibiting the activity of 5alpha-reductase and an application of the traditional Chinese medicine composition to hair loss prevention cosmetics. The traditional Chinese medicine composition consists of cuscuta chinensis, herba siegesbeckiae, blackberry lily, semen allii tuberose, radix scrophulariae, scutellaria baicalensis, subprostrate sophora root and artemisia capillaries. Extracts of the traditional Chinese medicine composition can inhibit the activity of the 5alpha-reductase so that the synthesis of androgen of DHT (double hydrogen testosterone) is inhabited, the excellent function of preventing the sebrrheic alopecia is realized, and the traditional Chinese medicine composition can be used for preparing the hair loss prevention cosmetics.
Owner:龚盛昭
Traditional Chinese medicine enzyme for balancing male 5alpha-reductase
InactiveCN106110037ASolve the problem of seborrheic alopeciaBalance androgen secretionAlgae medical ingredientsCarbohydrate active ingredientsAndrogen secretionBearded tooth
The invention discloses a traditional Chinese medicine enzyme for balancing male 5alpha-reductase and relates to an alopecia prevention agent, in particular to a biological enzyme prevention alopecia agent. The traditional Chinese medicine enzyme is characterized in that a microbial enzyme is added to a traditional Chinese medicine extract in the ratio being 2:8, and the traditional Chinese medicine enzyme is prepared after mixing; the microbial enzyme is prepared from water, brown sugar, poria cocos, evergreen, tea seeds, rice vinegar, hericium erinaceus, seaweed powder and pine juice through fermentation; the traditional Chinese medicine extract is prepared from water extracts of lotus seeds, fresh ginger, hawthorn fruits, malt, red peony roots, twotoothed achyranthes roots, hiraute shiny bugleweed herbs, motherwort herbs, arnebia roots and Chinese angelica through mixing in weight ratio. Traditional Chinese medicines and the enzyme regulate spleen, stomach, liver and renal functions and balance androgen secretion of human bodies, so that 5alpha-reductase is balanced, and the problem of sebrrheic alopecia is solved basically.
Owner:黄剑忠
Method of treating men with testosterone supplement and 5alpha-reductase inhibitor
A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.
Owner:MERCK & CO INC
Method of Treating Men with Metabolic and Anthropometric Disorders
InactiveUS20080125403A1Avoids unpleasantAvoids dangerous side effectBiocideOrganic active ingredientsLipid formationLipid lowering
A method of safely and specifically treating the combined metabolic disturbances of insulin resistance and visceral adiposity in male subject with visceral adiposity, metabolic syndrome (also known as the ‘insulin resistance syndrome’, and ‘syndrome X’), type II diabetes, or insulin resistance by administering a 5-alpha reductase inhibiting compound of structural formula I, II, III, or IV is disclosed. The method is also concerned with the use of the 5alpha reductase inhibiting compound together with antidiabetic agents, lipid lowering agents, antihypertensive agents, antiobesity agents, testosterone, testosterone precursors, testosterone prodrugs, testosterone analogs, and other androgen receptor agonists for treating visceral adiposity, metabolic syndrome, type II diabetes and insulin resistance in men.
Owner:MERCK SHARP & DOHME CORP
Composition and product for preventing and treating alopecia and preparation method of product
ActiveCN110339134AHigh cure rateReduce anti-hair loss/hair growthCosmetic preparationsHair cosmeticsIrritationAndrogen
The invention belongs to the technical field of hair growth and particularly relates to a composition and product for preventing and treating alopecia and a preparation method of the product. The composition is prepared from rape pollens, rye pollens and pygeum africanum. In the composition, the rape pollens have an estrogen-like effect, reduce dandruff and prevent alopecia / promote hair growth, and the rye pollens and pygeum africanum can effectively inhibit the activity of 5alpha-reductase and reduce the excessive secretion of androgen. Experimental results show that the provided compositioncontaining specific components in a proportion for preventing and treating alopecia can achieve the effect of preventing and treating alopecia under the synergistic action, and the composition for preventing and treating alopecia has an obvious effect on alopecia prevention / promotion of hair growth and has no irritation to the skin.
Owner:广州馥邦科技应用有限公司
Methods and Compositions for Treating 5Alpha-Reductase Type 1 and Type 2 Dependent Conditions
The invention relates generally to the use of anti-sense oligonucleotides, small interfering RNA, and ribozymes to modulate expression of the human steroid 5α-reductase gene and thereby modulate levels of dihydrotestosterone (DHT). Elevated levels of DHT are associated with various disorders including, but not limited to, skin diseases, hair loss, hirsuitism, and benign prostatic hyperplasia. The invention specifically relates to formulations of these anti-sense oligonucleotides, small interfering RNA, and ribozymes for administration to treat and prevent disorders
Owner:HOKE GLENN D +1
Anti-hair-loss hair-care composition and application thereof
ActiveCN110064039AInhibitory activityPrevent proliferationCosmetic preparationsHair cosmeticsMalasseziaGuava Fruit
The invention discloses an anti-hair-loss hair-care composition and application thereof, and aims to provide a composition capable of effectively inhibiting the activity of 5alpha-reductase, reducingthe proliferation of malassezia fufur, and promoting the proliferation of dermal papilla cells. The composition is applied to toiletries, has a remarkable improvement effect on seborrheic alopecia, and is prepared from, by weight, 1-6 parts of a spiraea ulmaria extract, 3-9 parts of a guava fruit extract, 2.5-7 parts of a turmeric root extract, 2-5 parts of a magnolia bark extract and 5-10 parts of a tea extract. The invention belongs to the technical field of daily necessities.
Owner:广州鹰远生物科技有限公司
Steroid compound with 5-alpha reductase active and preparation process thereof
InactiveCN1793164AHas 5α-reductase inhibitory activitySimple processSteroids preparationKetoneCarboxylic acid
The invention discloses a structure of steroid class compound that has 5alpha-reductase to restrain activity that belongs to medicine chemical field. R1 is hydrogen, alkyl and benzyl of C1-C5; R2 is alkyl of C1-C8, alkanoyl of C1-C8, one from benzyl, substituted benzyl, benzoyl, and phenylacetyl and substituted benzoyl. It uses androstenedione as raw material, oxidizing open loop to form 5, 17-carbonyl-A-decarbonization-3, 5-cracking-androstane-3-carboxylic acid and taking reaction with oximation to form intermediate that would react with halogenated hydrocarbon or acyl chloride to gain the product. The advantages of the invention are that it uses common raw material, simple technology, has the activity restraining function to 5alpha-reductase.
Owner:TIANJIN UNIV
Chinese medicinal composition and application thereof
ActiveCN101850048AInhibitory activityAdjust buildUrinary disorderDermatological disorderDiseaseProstate hyperplasia
The invention discloses a Chinese medicinal composition and application thereof. The Chinese medicinal composition is prepared from Chinese herbal medicaments, namely, rhizoma anemarrhenae and fructus forsythiae. The Chinese medicinal composition has higher action of inhibiting 5alpha-reductase compared with a single Chinese medicinal extract and can be applied to transdermal administration preparations, cosmetics or health-care food to achieve effects of treating diseases such as acne, benign prostatic hyperplasia, alopecia and the like.
Owner:LB COSMECEUTICAL TECH CO LTD +1
Hair-care loss-preventing composition and application thereof
InactiveCN108309896AValid reservationEfficient retentionCosmetic preparationsHair cosmeticsAlopecia seborrhoeicaBiology
The invention discloses a hair-care loss-preventing composition and application thereof. The hair-care loss-preventing composition is prepared from the following components in parts by weight: 0.1-10parts of linfa leaves and 0.1-10 parts of walnut. The hair-care loss-preventing composition is obtained through a lot of experiments and researches by an inventor, the linfa leaves and the walnut arecarefully selected, and the optimal proportion of the linfa leaves and the walnut is obtained, so the obtained composition is safe and non-toxic, has the very strong effect of inhibiting the 5Alpha-reductase activity, and is capable of promoting the metabolism of scalp cells, increasing the scalp blood microcirculation, thereby inhibiting the synthesis of special male sex hormone DHT, and effectively treating a alopecia seborrhoeica symptom caused by an androgen source character. Rhizoma anemarrhenae and flos carthami are compounded, and can penetrate into a hair follicle so as to form a screen-type protective film, so the secretion of oil contamination of the hair follicle is controlled, and the loss of the grown hairs is prevented. Especially, the linfa leaves and the walnut are compounded, the hair follicle is conveniently stimulated, the scalp cells are activated, the blood circulation is reinforced, and the regeneration of the hairs is promoted.
Owner:FOSHAN YUNSHANG COSMETICS CO LTD
Helichrysum extract and extraction method and application thereof
ActiveCN109331052APromote growthStrong inhibitory activityCosmetic preparationsHair cosmeticsWaxHair growth
The invention relates to the technical field of helichrysum extracts and application thereof, and discloses a helichrysum extract and an extraction method and application thereof. The helichrysum extract takes a helichrysum extract A for example; the helichrysum extract A is obtained by a method comprising the following steps: extracting a helichrysum inflorescence with an ethanol solution while heating to obtain an extracting solution, and filtering and concentrating the extracting solution to obtain the helichrysum extract A. The invention discloses application of the helichrysum extract A,a helichrysum extract B, a helichrysum extract C, a helichrysum extract D and a helichrysum extract composition to preparation of medicines or / and daily chemical products for promoting hair growth or / and treating seborrheic alopecia or / and treating acnes for the first time, and provides a novel way for treating the seborrheic alopecia and the acnes and promoting the hair growth; and in addition, the 5alpha-reductase inhibiting activity of the helichrysum extract D is higher than that of finasteride.
Owner:张显文 +1
Medicine for treating sebrrheic alopecia
InactiveCN106729273AQuick effect and no recurrenceAvoid conversionAnthropod material medical ingredientsRotary stirring mixersLepidium meyeniiDihydrotestosterone
The invention discloses a medicine for treating sebrrheic alopecia. The medicine is prepared from the following Chinese herbal medicines in parts by weight: 10 to 15 parts of semen myristicae, 23 to 27 parts of nettle, 10 to 17 parts of lotus plumule, 3 to 7 parts of raspberry fruit, 4 to 6 parts of spica prunellae, 6 to 8 parts of fructus mori albae, 3 to 5 parts of herba cistanches, 3 to 5 parts of semen cuscutae, 3 to 5 parts of corn stigma, 4 to 7 parts of lepidium meyenii walp, 7 to 9 parts of taro, 2 to 4 parts of Chinese teasel root, 6 to 9 parts of tetrapanax papyrifer, 2 to 5 parts of fructus aurantii, 1 to 3 parts of rhizoma alpiniae officinarum, 5 to 7 parts of edible tree fungus, 6 to 8 parts of cicada slough, 4 to 6 parts of whitish honey, 8 to 10 parts of polycarpaea corymbosa and 6 to 8 parts of narrow leaf spicebush. The medicine can be used for effectively inhibiting 5alpha-reductase so that testosterone is prevented from being converted into dihydrotestosterone and the sebrrheic alopecia is further treated.
Owner:傅天锡
Medicinal composition containing insoluble medicament
InactiveCN102145003BAvoid degradationAvoid Absorption IrregularitiesOrganic active ingredientsPoor complianceSide effect
Owner:张立英
New medicinal use of Chinese medicine nutmeg and its extract
ActiveCN100586469CGood treatment effectSignificant effectUrinary disorderPlant ingredientsCurative effectProstate hyperplasia
The present invention relates to new medicinal use of Chinese medicine nutmeg and its extract. Specifically, nutmeg and its extract is used in preparing 5alpha-reductase inhibitor and prostatic hyperplasia treating medicine with obvious curative effect, low cost and convenient use.
Owner:CHENGDU DIAO PHARMA GROUP
Chinese medicinal composition and application thereof
ActiveCN101850048BInhibitory activityAdjust buildUrinary disorderDermatological disorderDiseaseProstate hyperplasia
The invention discloses a Chinese medicinal composition and application thereof. The Chinese medicinal composition is prepared from Chinese herbal medicaments, namely, rhizoma anemarrhenae and fructus forsythiae. The Chinese medicinal composition has higher action of inhibiting 5alpha-reductase compared with a single Chinese medicinal extract and can be applied to transdermal administration preparations, cosmetics or health-care food to achieve effects of treating diseases such as acne, benign prostatic hyperplasia, alopecia and the like.
Owner:LB COSMECEUTICAL TECH CO LTD +1
Composition containing Saxifragaceae Chrysosplenium delavayi extract and application of composition
InactiveCN110279726AEasy to scale upHigh purityOrganic active ingredientsBacteria material medical ingredientsDiseasePhysiology
The invention provides composition containing Saxifragaceae Chrysosplenium delavayi extract. The composition comprises the Saxifragaceae Chrysosplenium delavayi extract, salmonella typhimurium extracellular vesicles and 2-[(4-tert-butylthiazole-2-yl)imido] thiazoline-4-one, wherein the grain size of the salmonella typhimurium extracellular vesicles is in a range of 50-300 nm. By means of mutual compatibility of the components of the composition, the composition can have an activity inhibiting effect on 5alpha-reductase to different degrees, can be used as a 5alpha-reductase inhibitor, and can be applied to prevention and / or treatment of body discomfort such as hair loss, brittleness and easy breaking of hair, alopecia areata, acne, hair color fading and combination of the symptoms caused by 5alpha-reductase or androgen dependent diseases such as androgenic alopecia, benign prostatic hyperplasia and prostatic cancer easily caused by high-level dihydrotestosterone.
Owner:嘉兴市爵拓科技有限公司
Method of treating men with testosterone supplement and 5alpha-reductase inhibitor
InactiveUS20110136769A1Minimizes unpleasantMinimizes potentially dangerous side effectBiocideMowersAviptadilDisease
A method of treating Alzheimer's disease, Parkinson's disease, sexual dysfunction or erectile dysfunction in a man by administration of a 5alpha reductase inhibitor together with a testosterone supplement is described. The method is also concerned with the use of the 5alpha reductase inhibiting compound and the testosterone supplement together with another agent useful for treating erectile dysfunction, including PDE V inhibitors; AGE (advanced glycation end-product) breakers; alpha 1 blockers; alpha 1A antagonists; alpha 2 antagonists; dopamine agonists; dopamine D4 agonists; melanocortin agonists; oxytocin agonists; prostaglandin; radical scavengers; rotamase inhibitors; aviptadil; nitroglycerine; and GPCR agonists for treating male sexual dysfunction or erectile dysfunction.
Owner:MERCK SHARP & DOHME CORP
Medicinal composition and application thereof
ActiveCN101879156BInhibitory activityInhibition of secretionAntipyreticAnalgesicsAromataseCyclooxygenase
Owner:JIANGSU KANION PHARMA CO LTD +1
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