Medicinal composition and application thereof

Abstract

The invention discloses a medicinal composition, which comprises two or three of a, b and c, wherein a is long-chain fatty acid compounds of a formula I or plant extract containing the same; b is flavonoid compounds of a formula II or plant extract containing the same; and c is the following alkaloid compounds or plant extract containing the same: N1,N5,N10-tri-(E / Z)-coumaroyl spermidine, 1-O-(beta-D-glucose)-(2S, 3S, 4R)-2N-[(2'R)-2'-hydroxytetracosenoicacid]-octadecylene-3,4-diol, putrescine and indol-3-acetic acid. The medicinal composition of the invention can be used for preparing aromatizing enzyme inhibitor, 5alpha reductase inhibitor, alpha1-adrenergic receptor antagonist, cyclooxygenase-2 inhibitor, prostate-specific antigen (PSA) secretion inhibitor, anti-inflammation medicamentor medicament for resisting prostatic hyperplasia, prostatitis or prostatic cancer.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to a pharmaceutical composition and its application. Background technique [0002] Benign prostatic hyperplasia (BPH) is a common physiological disease in elderly men. When the disease causes a series of symptoms such as urinary obstruction, it is called benign prostatic hyperplasia. The autopsy reports of 1075 cases abroad show that: at the age of 25 to 30, 10% of men can see early benign prostatic hyperplasia lesions under the microscope; with the increase of age, the incidence of histologically diagnosed prostatic hyperplasia also increases accordingly; To 51 to 60 years old, the incidence rate increased to 75%; to 85 years old, about 90% of men had histological benign prostatic hyperplasia lesions. It can be seen from the above that with the acceleration of the aging of the population in my country, the incidence of benign prostatic hyperplasia caused by aging continu...

AI Technical Summary

Problems solved by technology

Prostatic hyperplasia is a group of diseases with multiple etiologies and requires long-term medication. If synthetic drugs such as α1-receptor blockers and 5α-reductase inhibitors that only target a specific target point have certain side effects during long-term use, such as Hypotension, impotence, sexual dysfunction, headache, etc., and the treatment effect is not satisfactory, thus limiting the application of these drugs in the treatment of benign prostatic hyperplasia

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