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Chinese medicinal composition and application thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its application, can solve problems such as poor effect and large side effects, and achieve the effect of controlling prostatic hyperplasia, small side effects, and low drug concentration

Active Publication Date: 2010-10-06
LB COSMECEUTICAL TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition and its application in order to overcome the defects that most of the existing drugs for inhibiting 5α-reductase are western medicines, have relatively large side effects and poor effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take 90g of forsythia and 10g of Anemarrhena, prepare extract A: volume concentration 70% ethanol water solution (V / V), configure extract B: volume concentration 70% ethanol water solution (V / V), configure eluent A: volume Concentration 80% ethanol aqueous solution (V / V), configure eluent B: volume concentration 80% ethanol aqueous solution (V / V), select non-polar resin column: HZ891, original drug: extract: resin: eluent = 1:10:3:9.

[0030] Crush Forsythia and extract with extract A at 50°C for 5 hours, concentrate relative density between 1.0 and 1.2, adsorb and elute through non-polar resin column, collect eluent A elution fraction. Crush Anemarrhena, extract with extract B at 50°C for 5 hours, concentrate relative density between 1.0 and 1.2, absorb and elute through non-polar resin column, collect eluent B elution fraction. Mix the two eluted sections and concentrate to the extract to obtain the composition of mother and forsythia extract.

Embodiment 2

[0032] Take 75g of forsythia and 25g of Anemarrhena, prepare extract A: volume concentration 70% ethanol water solution (V / V), configure extract B: volume concentration 70% ethanol water solution (V / V), configure eluent A: volume Concentration 80% ethanol aqueous solution (V / V), configure eluent B: volume concentration 80% ethanol aqueous solution (V / V), select non-polar resin column: D-101, original drug: extract: resin: elution liquid=1:15:2:6.

[0033] Crush Forsythia and extract with extract A at 30°C for 48 hours, concentrate to a relative density of about 1.0 to 1.2, adsorb and elute through a non-polar resin column, and collect the elution fraction of eluent A. Crush Anemarrhena and extract with extract B at 30°C for 48 hours. The relative density of concentration is about 1.0-1.2. It is adsorbed and eluted by a non-polar resin column, and the elution section of eluent B is collected. Mix the two elution segments to obtain the composition of mother and forsythia extrac...

Embodiment 3

[0035] Take 25g of forsythia and 75g of Anemarrhena, prepare extract A: volume concentration 70% ethanol water solution (V / V), configure extract B: volume concentration 70% ethanol water solution (V / V), configure eluent A: volume Concentration 80% ethanol aqueous solution (V / V), configure eluent B: volume concentration 80% ethanol aqueous solution (V / V), select non-polar resin column: H-103, original drug: extract: resin: elution liquid=1:10:2:6.

[0036] Crush Forsythia and extract with extract A at 70°C for 3 hours, concentrate to a relative density of about 1.0-1.2, adsorb and elute through a non-polar resin column, and collect the elution fraction of eluent A. Crush Anemarrhena, extract with extract B at 70°C for 3 hours, concentrate relative density between 1.0 and 1.2, absorb and elute through a non-polar resin column, and collect the elution fraction of eluent B. Mix the two elution segments to obtain the composition of mother and forsythia extract.

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PUM

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Abstract

The invention discloses a Chinese medicinal composition and application thereof. The Chinese medicinal composition is prepared from Chinese herbal medicaments, namely, rhizoma anemarrhenae and fructus forsythiae. The Chinese medicinal composition has higher action of inhibiting 5alpha-reductase compared with a single Chinese medicinal extract and can be applied to transdermal administration preparations, cosmetics or health-care food to achieve effects of treating diseases such as acne, benign prostatic hyperplasia, alopecia and the like.

Description

technical field [0001] The invention relates to a composition and its application, in particular to a traditional Chinese medicine composition and its application. Background technique [0002] Human 5α-reductase is a protease that relies on reduced coenzyme I (NADPH) to catalyze testosterone (T) to dihydrotestosterone (DHT). As a hydrogen donor, NADPH participates in the catalysis of 5α-reductase, and the catalytic reaction reduces NADPH to NADP + , the hydrogen ions are transferred to the α-face with less steric hindrance of the substrate, so that T is converted into DHT to form a more active androgen. If the level of DHT in the human body is too high, it will cause diseases such as acne, benign prostatic hyperplasia and hair loss. To reduce DHT levels, inhibition of 5α-reductase activity is very important. [0003] Acne is a complex, chronic and universal sebaceous gland dysfunction disease, which generally occurs in adolescence and is closely related to the level of a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P17/10A61P13/08A61P17/14A23L1/29A23L33/00
Inventor 李成亮
Owner LB COSMECEUTICAL TECH CO LTD
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