33results about How to "Strong immunogen specificity" patented technology

The invention relates to an oestrone derivative for detecting oestrone content in a biological sample and a preparation method of the oestrone derivative. The structural formula of the oestrone derivative is shown as a formula (I). Oestrone immunogens with high immunogenicity and corresponding antibodies are prepared in succession by using the oestrone derivative. The oestrone immunogen is high inspecificity and high in immunogenicity, and the anti-oestrone specific antibody is high in specificity and high in titer, is capable of well recognizing and binding oestrone, and does not have any cross reaction with common 92 chaff interferents. The invention further discloses an oestrone enzyme-labeled conjugate, and an oestrone homogeneous enzyme immunoassay detection reagent is prepared by utilizing the anti-oestrone specific antibody and the oestrone enzyme-labeled conjugate. The reagent is capable of conveniently, rapidly, and accurately measuring the oestrone content in the biologicalsample, multiple samples are determined on a full-automatic biochemical analyzer, high throughput and rapid determination of the oestrone is realized, the accuracy is high, the specificity is high, and the accuracy and detection efficiency are greatly improved compared with the previous detection.

The invention discloses a derivative of 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), a homogeneous enzyme immunoassay reagent and a preparation method thereof, and relates to the technical field of biological detection. Using the HPHPA derivative to prepare a highly immunogenic HPHPA immunogen and its antibody, the antibody has strong specificity and high titer, and has no cross-reaction with 92 common interfering substances. The detection reagent can realize high-throughput and rapid detection of HPPA on an automatic biochemical analyzer, with high detection accuracy, strong specificity, and significantly improved detection efficiency.

The invention relates to a mycophenolic acid detection reagent as well as preparation and detection methods thereof and particularly relates to a mycophenolic acid homogeneous phase enzyme immunological detection reagent as well as preparation and detection methods thereof. The mycophenolic acid homogeneous phase enzyme immunological detection reagent comprises an anti-mycophenolic acid specific antibody, and an indication reagent for detecting an anti-mycophenolic acid specific antibody-mycophenolic acid compound; and the anti-mycophenolic acid specific antibody is prepared from mycophenolic acid immunogen immunological animals. The mycophenolic acid detection reagent has the beneficial effects that mycophenolic acid immunogen has strong specificity and high immunogenicity; the prepared anti-mycophenolic acid specific antibody has strong specificity and high valence and has no crossed reaction with common 62 types of medicines; the homogeneous phase enzyme immunological detection reagent containing the anti-mycophenolic acid specific antibody can be used for conveniently, rapidly and accurately determining the content of mycophenolic acid in a sample, and determining a plurality of samples on a full-automatic biochemical analyzer at the same time, so that the high-flux rapid determination for the mycophenolic acid is realized; and the accuracy is high, the specificity is strong, and the accuracy and the detection efficiency can be relatively greatly improved.

The invention discloses an aldosterone derivative, a preparation method thereof, an aldosterone homogeneous enzyme immunoassay reagent and preparation and detection methods thereof. The aldosterone derivative has a structure shown as a formula (I), an aldosterone immunogen with high immunogenicity and an antibody of the aldosterone immunogen are prepared from the aldosterone derivative, and the aldosterone homogeneous enzyme immunoassay reagent prepared from the antibody can be used for realizing high-flux and high-speed detection of aldosterone on a fully-automatic biochemical analyzer.

The invention discloses a docetaxel immunogen, a synthetic method of the docetaxel immunogen, an anti-docetaxel antibody obtained by the immunogen, a detection reagent and a preparation method of the anti-docetaxel antibody. The docetaxel immunogen disclosed by the invention is synthesized by brand-new docetaxel derivatives and has the advantage of high immunogenicity, an anti-docetaxel specific antibody with high specificity and binding force can be obtained by induction, and any cross reaction with common 62 medicines is avoided. According to the docetaxel detection reagent prepared from the antibody, the content of docetaxel in a sample can be conveniently and accurately determined, and clinical individualized treatment is promoted. Compared with the method in the prior art, the detection reagent disclosed by the invention can realize high-flux and rapid detection on a fully automatic biochemical analyzer and has the advantages of simple and convenient operation, high sensitivity, high specificity, accurate result and the like, the detection cost of the docetaxel can be effectively reduced, and the detection reagent is suitable for large-scale clinical popularization and application.

The invention relates to a dipeptide derivative for detecting angiotensin I as well as a preparation method and application thereof. The dipeptide derivative is a leucine-histidine dipeptide derivative and a structural formula is shown as a formula (I) as follows: the formula (I) is shown in the description. According to the dipeptide derivative provided by the invention, the leucine-histidine dipeptide derivative, repeated tests are carried out and an immunogen and a corresponding antibody are prepared in a pioneering manner by selecting two amino acid residues at the tail end of carboxyl ofthe angiotensin I; the obtained antibody can be used for identifying and combining the angiotensin I and a plurality of samples can be simultaneously determined on a full-automatic biochemical analyzer, so that high-throughput and rapid determination of the angiotensin I is realized; the dipeptide derivative has high accuracy and strong specificity; the precision and the detection efficiency are greatly improved when being compared with previous precision and detection efficiency; meanwhile, full automation of a detection process is realized, requirements on inspectors are not high and the dipeptide derivative is easy to realize, popularize and apply.

The invention discloses an estriol homogeneous phase enzyme immunoassay reagent as well as a preparation method and a detection method thereof and belongs to the technical field of immunoassay reagents. An estriol immunogen prepared by the invention is high in immunogenicity, can be induced to obtain a high-titer anti-estriol specific antibody and does not have any cross reaction with 62 common drugs. The estriol immunoassay reagent prepared by the antibody is capable of accurately and rapidly determining the estriol content in biological samples such as urea, blood and the like. Compared with the existing assay reagents in the market as well as detection methods and preparation methods thereof, the detection reagent disclosed by the invention has the advantages of simplicity and convenience in operation, high sensitivity, high specificity, accurate result and the like, is capable of effectively reducing the estriol detection cost and is favorable for large-scale clinical popularization and application.

The invention discloses a carbamazepine immunogen, a carbamazepine specific antibody directly obtained through the immunogen, a detection reagent containing the specific antibody and a method for detecting the content of the carbamazepine in samples to be tested. The immunodetection reagent and the detection method have the advantages that the carbamazepine immunogen is strong in specificity and high in immunogenicity; the prepared carbamazepine immunogen is strong in specificity and high in titer and has no cross reaction with 45 common drugs; the homogeneous enzyme immunodetection reagent containing the carbamazepine specific antibody can conveniently, fast and accurately determine the content of the carbamazepine in the samples and can measure a plurality of samples simultaneously on a full-automatic biochemical analyzer, so that high-throughput and fast measuring of the carbamazepine are achieved, the accuracy is high, the specificity is strong, the accuracy and the detection efficiency are greatly improved compared with the prior art, full automation in the detection process is achieved simultaneously, the requirements on detection staff is not high, and the immunodetection reagent and the detection method are easy to achieve, popularize and use.

The invention discloses a cyclosporin A immunogen and a synthesis method thereof, as well as an anti-cyclosporin A antibody obtained from the immunogen, a detection reagent and a preparation method of the cyclosporin A immunogen. The cyclosporin A immunogen prepared by the preparation method disclosed by the invention has high immunogenicity and can obtain the anti-cyclosporin A specific antibody which has high valence and no cross reaction with common 62 medicines by induction; and the cyclosporin A detection reagent prepared from the antibody can precisely and rapidly determine the content of cyclosporin in a sample. Compared with the existing detection reagent in the market, the detection reagent disclosed by the invention has the advantages of simplicity and convenience in operation, high sensitivity, strong specificity, accurate result and the like, can effectively reduce the detection cost of cyclosporin A and is conductive to clinical large-scale popularization and application.

The invention relates to a dipeptide derivative for detecting Ang II and a preparation method and application of the dipeptide derivative for detecting Ang II. The dipeptide derivative is a proline-phenylalanine dipeptide derivative, and has the structural formula as shown in the following formula (I). The proline-phenylalanine dipeptide derivative is prepared pioneeringly by selecting two amino acid residues at the carboxyl terminal of Ang II through repeated experiments, highly immunogenic small-molecule immunogen and a corresponding antibody are obtained through the prepared proline-phenylalanine dipeptide derivative, a homogeneous enzyme immunoassay reagent containing the anti-Ang II specific antibody can conveniently, quickly, and accurately determine the content of Ang II in a biological sample, and multiple samples can be determined at the same time on an automatic biochemical analyzer to realize high-throughput and rapid determination of Ang II, so that the precision is high, the specificity is strong and the accuracy and detection efficiency are greatly improved compared with the previous accuracy and detection efficiency.

The invention discloses a catecholamine immunogen, a ramification and a synthetic method, a specific antibody and a detection reagent and a preparation method. The prepared catecholamine immunogen is high in immunogenicity, a high-titer anti-catecholamine specific antibody can be obtained by inducing of the prepared catecholamine immunogen, and no cross reaction of the prepared catecholamine immunogen with 62 common medicines occurs; catecholamine detection reagent is obtained by preparing the antibody, and catecholamine content of a sample can be determined precisely and rapidly. Compared with an existing detection reagent on the market, the detection reagent has the advantages that the operation is simple, the sensitivity is high, the specificity is strong, and the result is precise, the catecholamine detection cost can also be lowered, and the detection reagent can be easily popularized and used at clinic in a large scale.