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The present invention relates to a novel antiplatelet agent and a novel compound which is an active ingredient for the agent. The present invention provides the antiplatelet agent comprising a compound represented by the formula I:wherein,X is N, or CR1d,Xb1-Xb5 are the same or different, and are nitrogen or carbon,R1a-R1d are the same or different, and are hydrogen, an optionally substituted alkyl, an optionally substituted alkoxy, an optionally substituted alkylthio, an alkenyl, a cycloalkyl, a halogen, cyano, or hydroxyl or optionally substituted by 1 or 2 alkylamino,R2 is an optionally substituted aryl or an optionally substituted heteroaryl,R3 is an optionally substituted aryl or an optionally substituted heteroaryl, orpharmaceutically acceptable salt thereof as an active ingredient.

An optical substrate such as a cover glass which effects only a small change in a reflected color dependent on an incident angle, or more particularly, an optical substrate such as a cover glass for displays includes a reinforcement layer intended to prevent cracking, an antiglare layer formed on the reinforcement layer, a tone-adjustment antireflection film formed on the antiglare layer, and an antifouling layer formed on the antireflection film intended to minimize fingerprint adhesion. The antireflection film includes at least nine layers.

Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formulawherein each symbol is as defined in the specification, or a salt thereof.

An instrument positions an intervertebral implant for the fusion between two vertebral bodies of a vertebral column. The instrument may include a handle having a proximal and a distal end, a locking shaft extended from the distal end of the handle, and a grasping head at the distal end of the shaft. The locking shaft may be cannulated, and a stem may be hosted inside the cannulated shaft passing through the handle. The stem may be free to rotate with respect to the locking shaft, or vice versa, while the grasping head may be formed at the distal end of the stem with a couple of prongs or clamps toward the other according to an angular relative rotation of the stem with respect to the locking shaft. The instrument may allow the surgeon to grip a corresponding implant with a simple rotation movement of his hand.

An instrument positions an intervertebral implant for the fusion between two vertebral bodies of a vertebral column. The instrument may include a handle having a proximal and a distal end, a locking shaft extended from the distal end of the handle, and a grasping head at the distal end of the shaft. The locking shaft may be cannulated, and a stem may be hosted inside the cannulated shaft passing through the handle. The stem may be free to rotate with respect to the locking shaft, or vice versa, while the grasping head may be formed at the distal end of the stem with a couple of prongs or clamps toward the other according to an angular relative rotation of the stem with respect to the locking shaft. The instrument may allow the surgeon to grip a corresponding implant with a simple rotation movement of his hand.

Stability of a circuit operation in a monolithic gate driver is improved. A bistable circuit is provided with a charge replenishment circuit (71) including: a capacitor (CAP2); a thin-film transistor (MA) having a first electrode supplied with a first clock for charge replenishment (CKA), a second electrode connected to a third-node (N3) connected to one end of the capacitor (CAP2), and a third electrode connected to a second-node (N2) to be maintained at the high level during a normal operation period; and a thin-film transistor (MB) having a first electrode supplied with a second clock for charge replenishment (CKB), a second electrode supplied with a high-level DC power supply potential (VDD), and a third electrode connected to the third-node (N3). The first clock for charge replenishment (CKA) and the second clock for charge replenishment (CKB) are alternately driven to the high level so as to eliminate a period in which “the first clock for charge replenishment (CKA) is at the high level and the second clock for charge replenishment (CKB) is at the high level”.

Provided is a method for treating drug-induced constipation comprising a step of administering an effective amount of a 15-keto-prostaglaindin compound to a subject suffering from drug-induced constipation or a subject having a strong possibility of suffering from it. According to the present invention, a strong antagonistic action against drug-induced constipation can be obtained without substantially losing the main effect of the drug.

The invention discloses a tracheal foreign body forceps device and forceps body. The forceps body is integrally molded by elastic rubber or plastic. The structure of the forceps body is formed by successively and integrally connecting a circular tubular tube joint b, a circular tubular supporting ring, a spherical rib connecting surface and four clamping slices, wherein the rib connecting surface concavely extends into the supporting ring; the four clamping slices are evenly and tightly connected at the periphery of the outer surface of the rib connecting surface; the end parts of the four clamping slices are surrounded to form a circular front opening; a side gap is formed between the adjacent two clamping slices; supporting ribs are formed on the inner side of each clamping slice; the bottoms of the supporting ribs are connected onto the outer surface of the rib connecting surface. The forceps body is integrally molded by the elastic rubber or plastic, so that the forceps body is convenient to machine, low in production cost and smooth in surface, and has no burr or sharp end part. Thus, the discomfortableness and the damage of the forceps body to tracheas are tiny.

A process for extracting cis-ligustilide includes such steps as pretreating, pulverizing, high-shear extracting, separating and purifying. Its advantages are low toxin and high output rate and purity. It can be used in preparing the medicine for prevent and treat the diseases associated with microcirculation disorder.

(R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.

The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formulawherein each substituent is as defined in the present specification, or a salt thereof.

A method for treating a fracture of a bone with a medullary canal. A first and a second group of three elongated monocortical pins are provided. Each pin has a stem with a first end portion having a conical shape with an external thread for insertion into a cortical portion of a bone. Each pin of the first and second group of three monocortical pins is inserted a predetermined distance from the bone fracture, and penetrates only into the cortical portion of the bone without reaching the medullary cavity, the pins of the first and second group being inserted such that they are not coplanar to each other. The stems of the pins of the first and groups are blocked to a first and a second common clamp element respectively. The first and second clamp elements are joined to a common rod to form a rigid external fixation system.

A seal backup ring is provided with undulating surfaces which create circumferential convergence with a relatively rotatable surface. The backup ring is configured so that differential pressure acting across a rotary seal forces portions of the backup ring against the relatively rotatable surface, closing, or substantially closing, the extrusion gap that the rotary seal is exposed to. In response to relative rotation between the backup ring and the mating relatively rotatable surface, the circumferential convergence promotes hydrodynamic lubrication within the dynamic interface that exists between the backup ring and the relatively rotatable surface. The modulus of elasticity of the backup ring is greater than the modulus of elasticity of the rotary seal.

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:

A preventing or treating agent for glaucoma is provided. This drug has a strong action of reducing intraocular pressure such that the intraocular pressure can be reduced even from the normal intraocular pressure. More specifically, a prophylactic or therapeutic agent for glaucoma, a preventing or treating agent for ocular hypertension, and eye drops containing (S)-(-)-1-(4-fluoro-5-isoquinolinesulfonyl)-2-methyl homopiperazine or its salt and phosphoric acid or its salt are provided.

The present invention relates to the compound represented by formula (I):(wherein, all the symbols has the same meanings as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof.Since the compound of the present invention has an anti stress action, it is useful for preventive and / or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.

The present invention relates to a pharmaceutical composition useful for preventing / treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.

To present a method of manufacturing a multipitch screw easily by using flat dies suited to mass production. A flat die 4 includes linear ordinary screw threads 40a, and multipitch screw threads 40b consecutive to the ordinary screw threads 40a, slightly shorter in height than the ordinary screw threads 40a, with both side walls formed alternately and consecutively, alternating between a section departing from the central line 40c of screw threads and an approaching section along a central line 40c, and symmetrically to the central line 40c of screw threads. After forming the tacks of a constant lead angle screw on the outer circumference of a shaft-like blank piece by the ordinary screw threads 40a, tracks of a multipitch screw are formed by the multipitch screw threads 40b, and therefore the tracks of a multipitch screw varying in the force applied at the time of rolling can be formed easily.

The invention relates to an elongated pin (2) for an external modular fixation system for temporary and / or permanent fixation applications to treat bone fractures and to connect two or more bone fragments to each other, comprising an elongated stem (3) extending along a longitudinal axis with a first end portion (4) and an opposite second end portion (5), said first end portion (4) having a tip for the insertion of the first end portion (4) into a bone, wherein said first end portion (4) has a conical shape with an external thread, forming a conical threaded end portion, the extension of said conical threaded end portion along the longitudinal axis being determined by the depth of penetration of the conical end portion limited to only the cortical portion of the bone.

Provided is a method of chemical-mechanical planarization of copper multilayer interconnection structures and of controlling the dishing problem associated therewith comprising: (a) preparing a slurry by (i) diluting SiO2 hydrosol with deionized water; (ii) admixing a chelating agent and adjusting the pH to between 9.5 to 11.5; and (iii) admixing nonionic surfactant(s) and oxidant(s); (b) applying said slurry to said copper multilayer interconnection structures; and (c) polishing said copper multilayer interconnection structures with polishing pad(s). The flow speed is 200-5000 ml / min, the temperature is 20-40° C., the rotation speed is 60-120 rpm, the pressure is 100-250 g / cm2, and the polishing speed can be 200-1100 nm / min. The process involves 1-5 min for polishing the copper and then 30-60 sec for polishing the copper, the barrier layer, and the dielectric layer. Consistent polishing speeds for the copper, the barrier layer, and the dielectric layer are achieved, which effectively reduces the dishing problem. At the same time, the method reduces the contamination of the surface with metal ions.

The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formulawherein each substituent is as defined in the present specification, or a salt thereof.

Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be used to trigger cell death on DR5 positive cells.

An ion trap comprises substantially elongate electrodes 10, 20 some of which are curved along their axis of elongation and which define a trapping volume between them. The sectional area of this trapping volume towards the extremities of the trap in the direction of elongation is different to the sectional area away from its extremities (eg towards the middle of the trap). In a preferred embodiment, the trap has a plurality of elongate electrodes, wherein opposed electrodes have different radii of curvature so that the trap splays towards its extremities. Thereby, a wider mass range of ions can be trapped and ejected, a higher space charge capacity (for a given trap length) is provided, and sharper ion beam focussing on ejection is possible.

The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and / or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

The invention discloses a health-care product for nourishing and protecting livers, which is characterized by comprising the following active constituents (in part by weight): 18-20 parts of fructus citri sarcodactylis, 10-15 parts of emblic leafflower fruit, 9-14 parts of poria, 8-13 parts of manyflower solomonseal rhizome, 7-11 parts of lucid ganoderma, 8-12 parts of hawthorn, 8-15 parts of kudzu roots, 4-7 parts of pearl, 3-6 parts of honeysuckle flower and 4-8 parts of liquorice. The health-care product for nourishing and protecting livers has the effects of protecting the livers, soothing the livers and regulating qi, clearing heat and detoxicating, promoting digestion and invigorating stomachs as well as harmonizing the stomach and relieving pains and is a new-generation health-care green food.

This invention relates to a method for treating thrombosis by combined administration of a pitavastatin with aspirin.