119results about How to "Strong action" patented technology

The present invention relates to a system (1) for improving the fixation of proximal fractures of the humerus, including at least a humeral nail (10) to be inserted in a humeral shaft (9) and comprising at least proximal transversal holes (5, 6, 7) for the passage of corresponding locking screws (3), at least a screw of said locking screws (3) having a screw head (4) and a screw body (31). The system further includes at least an intermediate plate element (15) inserted between the screw head (4) and the bone cortex surface (14) so that the head (4) is abutting against the plate (15). The intermediate plate element (15) is slightly bent to adhere substantially to the bone cortex surface (14) and comprises a couple of elongated arm portions (18, 19) that are inserted in an astride position on the screw body before the final fastening of the screw head (4). This solution allows to enlarge the abutting surface of the locking screw head against the bone cortex thus allowing a stronger fastening action and avoiding a rotation of the screw.

An optical substrate such as a cover glass which effects only a small change in a reflected color dependent on an incident angle, or more particularly, an optical substrate such as a cover glass for displays includes a reinforcement layer intended to prevent cracking, an antiglare layer formed on the reinforcement layer, a tone-adjustment antireflection film formed on the antiglare layer, and an antifouling layer formed on the antireflection film intended to minimize fingerprint adhesion. The antireflection film includes at least nine layers.

The present invention concerns a cleansing composition that imparts sun protection for the skin through normal daily use during bathing, washing, or cleaning of the body or face. The cleansing composition of the present invention comprises a unique combination of ingredients that provides therapeutic and restorative properties for the skin.

Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formula

wherein each symbol is as defined in the specification, or a salt thereof.

An instrument positions an intervertebral implant for the fusion between two vertebral bodies of a vertebral column. The instrument may include a handle having a proximal and a distal end, a locking shaft extended from the distal end of the handle, and a grasping head at the distal end of the shaft. The locking shaft may be cannulated, and a stem may be hosted inside the cannulated shaft passing through the handle. The stem may be free to rotate with respect to the locking shaft, or vice versa, while the grasping head may be formed at the distal end of the stem with a couple of prongs or clamps toward the other according to an angular relative rotation of the stem with respect to the locking shaft. The instrument may allow the surgeon to grip a corresponding implant with a simple rotation movement of his hand.

Stability of a circuit operation in a monolithic gate driver is improved. A bistable circuit is provided with a charge replenishment circuit (71) including: a capacitor (CAP2); a thin-film transistor (MA) having a first electrode supplied with a first clock for charge replenishment (CKA), a second electrode connected to a third-node (N3) connected to one end of the capacitor (CAP2), and a third electrode connected to a second-node (N2) to be maintained at the high level during a normal operation period; and a thin-film transistor (MB) having a first electrode supplied with a second clock for charge replenishment (CKB), a second electrode supplied with a high-level DC power supply potential (VDD), and a third electrode connected to the third-node (N3). The first clock for charge replenishment (CKA) and the second clock for charge replenishment (CKB) are alternately driven to the high level so as to eliminate a period in which “the first clock for charge replenishment (CKA) is at the high level and the second clock for charge replenishment (CKB) is at the high level”.

A device (1) and a spray head (5) for atomization of a preferably cosmetic liquid and a process for producing such a device are proposed. Very simple and accurate throttling of the liquid flow is achieved in that on the supply connection (14) of the spray head (5) a radially open throttling channel (22) is formed which is radially overlapped at least in sections by a connector piece (17) when the spray head (5) has been slipped on.

The invention discloses a tracheal foreign body forceps device and forceps body. The forceps body is integrally molded by elastic rubber or plastic. The structure of the forceps body is formed by successively and integrally connecting a circular tubular tube joint b, a circular tubular supporting ring, a spherical rib connecting surface and four clamping slices, wherein the rib connecting surface concavely extends into the supporting ring; the four clamping slices are evenly and tightly connected at the periphery of the outer surface of the rib connecting surface; the end parts of the four clamping slices are surrounded to form a circular front opening; a side gap is formed between the adjacent two clamping slices; supporting ribs are formed on the inner side of each clamping slice; the bottoms of the supporting ribs are connected onto the outer surface of the rib connecting surface. The forceps body is integrally molded by the elastic rubber or plastic, so that the forceps body is convenient to machine, low in production cost and smooth in surface, and has no burr or sharp end part. Thus, the discomfortableness and the damage of the forceps body to tracheas are tiny.

A process for extracting cis-ligustilide includes such steps as pretreating, pulverizing, high-shear extracting, separating and purifying. Its advantages are low toxin and high output rate and purity. It can be used in preparing the medicine for prevent and treat the diseases associated with microcirculation disorder.

(R)-2-(2-aminothiazol-4-yl)-4′-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or its salt shows a potent bladder relaxation effect in “isolated rat bladder smooth muscle relaxation test”, dose-dependently lowers the contraction frequency of rhythmic bladder contractions in “rat rhythmic bladder contraction measurement test” and, moreover, prolongs the urination intervals in “urination functions measurement test on cyclophosphamide-induced overactive bladder model rat”. Owing to these effects, the above compound is useful as a remedy for ovaractive bladder.

The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula

wherein each substituent is as defined in the present specification, or a salt thereof.

A seal backup ring is provided with undulating surfaces which create circumferential convergence with a relatively rotatable surface. The backup ring is configured so that differential pressure acting across a rotary seal forces portions of the backup ring against the relatively rotatable surface, closing, or substantially closing, the extrusion gap that the rotary seal is exposed to. In response to relative rotation between the backup ring and the mating relatively rotatable surface, the circumferential convergence promotes hydrodynamic lubrication within the dynamic interface that exists between the backup ring and the relatively rotatable surface. The modulus of elasticity of the backup ring is greater than the modulus of elasticity of the rotary seal.

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:

The present invention relates to the compound represented by formula (I):

(wherein, all the symbols has the same meanings as that of the specification), a salt thereof, a solvate thereof or a prodrug thereof.

Since the compound of the present invention has an anti stress action, it is useful for preventive and/or therapeutic agent for a disease caused by stress, especially a digestive system disease caused by stress and is superior to oral absorption.

The present invention relates to a pharmaceutical composition useful for preventing/treating pain, which comprises combination of gabapentin or pregabalin, or pharmaceutically acceptable salts thereof and N-type calcium channel antagonists or pharmaceutically acceptable salts thereof such as a compound having the following structure.

The invention relates to an elongated pin (2) for an external modular fixation system for temporary and/or permanent fixation applications to treat bone fractures and to connect two or more bone fragments to each other, comprising an elongated stem (3) extending along a longitudinal axis with a first end portion (4) and an opposite second end portion (5), said first end portion (4) having a tip for the insertion of the first end portion (4) into a bone, wherein said first end portion (4) has a conical shape with an external thread, forming a conical threaded end portion, the extension of said conical threaded end portion along the longitudinal axis being determined by the depth of penetration of the conical end portion limited to only the cortical portion of the bone.

Provided is a method of chemical-mechanical planarization of copper multilayer interconnection structures and of controlling the dishing problem associated therewith comprising: (a) preparing a slurry by (i) diluting SiO₂ hydrosol with deionized water; (ii) admixing a chelating agent and adjusting the pH to between 9.5 to 11.5; and (iii) admixing nonionic surfactant(s) and oxidant(s); (b) applying said slurry to said copper multilayer interconnection structures; and (c) polishing said copper multilayer interconnection structures with polishing pad(s). The flow speed is 200-5000 ml/min, the temperature is 20-40° C., the rotation speed is 60-120 rpm, the pressure is 100-250 g/cm², and the polishing speed can be 200-1100 nm/min. The process involves 1-5 min for polishing the copper and then 30-60 sec for polishing the copper, the barrier layer, and the dielectric layer. Consistent polishing speeds for the copper, the barrier layer, and the dielectric layer are achieved, which effectively reduces the dishing problem. At the same time, the method reduces the contamination of the surface with metal ions.

Anti-DR5 family member antibodies and bispecific antibodies comprising one or more anti-DR5 family member antibodies are disclosed. These antibodies can be used to trigger cell death on DR5 positive cells.

The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

The invention relates to a method for preparing nicotinamide-coated multivesicular liposomes. The nicotinamide-coated multivesicular liposomes are prepared from phospholipid, neutral lipid, cholesterol, an organic solvent, a hydrophilic emulsifier, nicotinamide, amino acid, an osmotic pressure regulator and deionized water. The method comprises the steps: dissolving the phospholipid, the cholesterol and the neutral lipid in the organic solvent, so as to obtain an organic phase; uniformly mixing the nicotinamide, the amino acid, the osmotic pressure regulator and the deionized water, so as to obtain an internal water phase; homogenizing the organic phase component, and adding the internal water phase component into the organic phase component, so as to prepare a W/O primary emulsion; mixing the hydrophilic emulsifier, the amino acid, the osmotic pressure regulator and the deionized water, and carrying out dispersing, so as to obtain an external water phase; homogenizing the external water phase component, adding the W/O primary emulsion component into the external water phase component, carrying out homogenizing, then, carrying out ultrasonic treatment, and then, cooling the mixture to room temperature with stirring, so as to form a W/O/W multiple emulsion; dispersing the multiple emulsion into an amino acid solution, introducing nitrogen gas into the solution to remove the organic solvent, thereby obtaining a nicotinamide-coated multivesicular liposome suspension. According to the method, the stability of the nicotinamide is improved.