44results about How to "Reduce the significance" patented technology

Prodrugs of guanfacine with amino acids or short peptides,pharmaceutical compositions containing such prodrugs and a method for providing therapeutic benefit in the treatment of ADHD / ODD (attention deficient hyperactivity disorder and oppositional defiance disorder) with guanfacine prodrugs are provided herein. Additionally, methods for minimizing or avoiding the adverse gastrointestinal side effects associated with guanfacine administration, as well as improving the pharmacokinetics of guanfacine are provided herein.

The invention relates to a dicyclic derivative of glucoside as well as a preparation method and the application of the dicyclic derivative. Specifically, the invention relates to a compound as shown in Formula I, a stereisomer or pharmaceutically acceptable salt or ester of the compound, a pharmaceutical composition of the compound, and application of the compound in preparation of drugs for treating diabetes or relevant diseases.

A system and method for resilient communication services under multi-chassis APS protected routers, including one or more of the following: an add-drop multiplexer; a working chassis; a plurality of working lines of communication between the add-drop multiplexer and the working chassis; a protection chassis; a plurality of protection lines of communication between the add-drop multiplexer and the protection chassis; and a multi-chassis APS control link between the working chassis and the protection chassis, wherein a plurality of active entities in the working chassis having state information send their state information to parallel inactive entities in the protection chassis by way of the multi-chassis APS, the active entities send changed state information to parallel inactive entities through the multi-chassis APS control link upon a state change in the active entities, and the inactive entities that were down request current state information from the active entities through the multi-chassis APS control link when the inactive entities that were down come back up after being down.

The invention discloses a multi-objective optimization method for radar radiation source signal sorting based on a membrane system. First, the traditional clustering is transformed into a multi-objective optimization problem, and then the membrane calculation optimization theory is used as the main line, and the genetic algorithm is integrated into the membrane structure framework. Algorithms, computational intelligence and other intelligent information processing technologies are intersected, and the self-improvement ability of the algorithm and the calculation efficiency and fusion ability of the current typical intelligent algorithms are compared to verify the convergence accuracy and effectiveness of the membrane system, in order to obtain multiple data sets with different clusters. The Pareto frontier solution maintains the diversity and difference of sorting results, which is conducive to the accuracy of later sorting. Combined with the nature of radiation source signal sorting, the clustering validity index, feature evaluation index and other evaluation criteria related to sorting are constructed into corresponding problem models and multi-objective functions. For the intercepted unknown radar signals, the essence of unsupervised classification is in line with the classification requirements of radar emitter signals.