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Kit for distinguishing colorectal adenomas from colorectal cancer

A technology for colorectal cancer and rectal adenoma, applied in the field of kits for distinguishing colorectal adenoma and colorectal cancer, can solve the problems of less than 40% early detection rate of colorectal cancer and lack of molecular markers, etc.

Active Publication Date: 2014-09-24
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have shown that early diagnosis of colorectal cancer is particularly critical. The five-year survival rate of colorectal cancer patients detected early is as high as 90%, and the survival rate of colorectal cancer patients with metastases is less than 10%. However, the current early detection rate of colorectal cancer is less than 40%. %
Molecular markers for the detection of colorectal cancer progression, known as the adenoma-neoplastic transition, are lacking

Method used

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  • Kit for distinguishing colorectal adenomas from colorectal cancer
  • Kit for distinguishing colorectal adenomas from colorectal cancer
  • Kit for distinguishing colorectal adenomas from colorectal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the construction of the kit for distinguishing colorectal adenoma and colorectal cancer

[0027] 1. Establishment of Molecular Model

[0028] 1. Blood collection, lipid molecule extraction and detection

[0029] 1) Research object

[0030] All samples were collected from May 2007 to May 2010. The samples came from the Second Artillery General Hospital of the PLA, Beijing Hospital, and the Second Affiliated Hospital of Peking University. Blood from fasting patients was taken in the morning for pretreatment. This project was approved by the Institutional Review Board, and all subjects signed informed consent.

[0031] Table 1 summarizes the basic information of the research subjects: 240 subjects were all Chinese, 61% were male (147 / 240), and the proportion of male in patients with colorectal adenoma and colorectal cancer was 63% % and 59%. The ages of adenoma patients and tumor patients were: 54.5+14.2 and 55.7+11.8, respectively, and there was no sign...

Embodiment 2

[0066] Example 2, the application of the kit for distinguishing colorectal adenoma and colorectal cancer

[0067] 1. Sensitivity and specificity detection for distinguishing colorectal adenoma from colorectal cancer

[0068] Blood from 120 colorectal adenomas (all clinically identified) and 120 patients with colorectal cancer (all clinically identified and diagnosed) were collected; in vitro plasma preparation, lipid Class extraction, liquid chromatography-mass spectrometer detection, obtain the content of SPC, 16:0SM, 18:0SM, 14:0LPC, 16:0LPC, 18:0LPC, 20:0LPC and 22:0LPC in plasma;

[0069] Take 0.044×SM total amount-60.1×SPC content as the abscissa, take the saturated LPC total amount as the ordinate, and use the formula of the model [0.044×SM total amount-60.1×SPC content-0.027×saturated LPC total amount=-1.06] Draw a straight line and make a graph.

[0070] The result is as figure 2 As shown in the right figure, the plasma 0.044×SM total amount – 60.1×SPC content in t...

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Abstract

The invention discloses a kit for distinguishing colorectal adenomas from colorectal cancer. The kit for distinguishing or assisting in distinguishing the colorectal adenomas from the colorectal cancer comprises a device for detecting phospholipids content and a contrast card established by the phospholipids content, wherein phospholipids are sphingosylphosphorylcholine (SPC), 16:0 sphingomyelin (SM), 18:0SM, 14:0 lysophosphatidylcholine (LPC), 16:0LPC, 18:0LPC, 20:0LPC and 22:0LPC. Saturated LPC, SPC and SM are taken as markers, and a molecular model for distinguishing the colorectal adenomas from the colorectal cancer is established, and has colorectal cancer distinguishing sensitivity of 90 percent and colorectal cancer distinguishing specificity of 93 percent.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a kit for distinguishing colorectal adenoma and colorectal cancer. Background technique [0002] Colorectal cancer is one of the most important malignant tumors, and more than one million people die of colorectal cancer every year. Because the occurrence of colorectal cancer is closely related to living habits, especially eating habits, with the gradual improvement of people's living standards in our country, the incidence and mortality of colorectal cancer are on the rise in my country. Studies have shown that early diagnosis of colorectal cancer is particularly critical. The five-year survival rate of patients with colorectal cancer detected early is as high as 90%, and the survival rate of patients with metastatic colorectal cancer is less than 10%. However, the current early detection rate of colorectal cancer is less than 40%. %. The "gold standard" for the diagnosis of colore...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 张俊杰李颂宋建稳徐燕桑建利丛羽生
Owner BEIJING NORMAL UNIVERSITY
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