The invention discloses a shank operation leg positioning device for an operating room. The shank operation leg positioning device comprises a bottom plate, a positioning mechanism is arranged above the bottom plate, the positioning mechanism comprises square rods, supporting plates, square cylinders, screws, convex plates, bolts, flitch plates, inserting rods, sliding rods, sleeves, arc-shaped plates and soft cushions, and the two square rods are located on the front side and the rear side of the upper surface of the bottom plate correspondingly. According to the shank operation leg positioning device for the operating room, through cooperation of the bottom plate and the positioning mechanism, medical staff place a shank to be operated of a patient on the upper surface of the bottom plate, an operation focus is located in the center of the upper surface of the bottom plate, and the positions of the square cylinders are adjusted by rotating the screws anticlockwise; and after adjustment is completed, the screws are rotated clockwise to abut against the square rods, then the bolts are rotated clockwise to enable the arc-shaped plates to abut against the principle focus of the shankof the patient, the to-be-operated shank of the patient can be clamped and positioned, and the shank of the patient is not prone to being interfered by external force in the operation.