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Composite material for implant and preparation method of composite material

A composite material and implant technology, applied in the field of composite materials for implants and their preparation, can solve problems such as poor antibacterial properties, and achieve the effects of increasing osteoinductivity, increasing biocompatibility, and reducing inflammation

Active Publication Date: 2021-05-28
广东湛美生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] An object of the present invention is to provide a composite material for implants, which can overcome the shortcomings of existing titanium materials such as poor antibacterial properties on the premise of having good biocompatibility similar to existing titanium materials

Method used

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  • Composite material for implant and preparation method of composite material
  • Composite material for implant and preparation method of composite material
  • Composite material for implant and preparation method of composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] A composite material for implants comprising a titanium metal base layer, a titanium dioxide nanotube layer, and a coating comprising hydroxyapatite and rare earth-doped metal-organic framework particles is prepared by the following steps.

[0116] Step (1): Titanium sheet pretreatment

[0117] Firstly, a titanium plate with a thickness of 0.1mm (purchased from Yitai Metal Co., Ltd.) was cut into titanium sheets with a size of 10x15mm. Immerse the titanium sheet in 10ml of acetone, 10ml of ethanol, and 10ml of deionized water in sequence, and ultrasonically clean it for 5 minutes, then take it out and dry it.

[0118] It is then immersed in HF, HNO at a volume ratio of 1:4:5 3 、H 2 O mixed acid solution (the total volume of the mixed acid solution is 10mL) for 15s to remove the metal oxide film on the surface.

[0119] Then ultrasonically wash with deionized water and dry naturally to obtain the pretreated titanium sheet.

[0120] Step (2): Preparation of titanium d...

Embodiment 2

[0134] Step (1): Titanium sheet pretreatment

[0135] Same as step (1) of Example 1.

[0136] Step (2): Anodizing

[0137] Same as step (2) of embodiment 1.

[0138] Step (3): Preparation of Rare Earth Doped Metal Organic Framework Particles

[0139] Dissolve zinc acetate dihydrate (0.35 g) in 10 mL of deionized water to form solution A. Dissolve 1.08 g of 2-methylimidazole in 10 mL of deionized water to form solution B.

[0140] Subsequently, solution B was slowly injected into solution A, and magnetically stirred for 1 minute to fully react to obtain a mixed solution. The mixed solution was then left to stand at room temperature for 24 hours. Next, the mixed solution was centrifuged, and the supernatant was decanted to obtain a solid product.

[0141] The solid product was washed with deionized water and centrifuged again, and this process was repeated three times,

[0142]Finally, the obtained product was dried in a vacuum oven at 60° C. for 12 hours to obtain metal ...

experiment example 1 2

[0152] Experimental example 1 Morphology inspection of titanium dioxide nanotube layer

[0153] The titanium sheet of comparative example 1 and the titanium sheet of the surface modification of the step (2) gained of embodiment 1 carry out surface morphology observation with scanning electron microscope respectively, obtain respectively figure 1 and 2 .

[0154] From figure 1 It can be seen from the figure that the spontaneously formed oxide film on the surface of the titanium sheet of Comparative Example 1 is irregular and has many cracks. This can easily lead to the peeling off of the oxide film after implantation in the human body, or the reduction of the stress strength of the titanium sheet, and it is easy to cause stress deformation, and there is a risk of secondary injury.

[0155] From figure 2 It can be seen from the figure that the surface of the surface-modified titanium sheet in Example 1 is a titanium dioxide nanotube layer, wherein the titanium dioxide nanot...

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Abstract

The invention relates to a composite material for an implant and a preparation method of the composite material. The composite material for the implant comprises a titanium metal substrate layer, a titanium dioxide nanotube layer and a coating comprising hydroxyapatite and rare earth doped metal organic framework particles. The method comprises the following steps: (1) pretreating a titanium sheet; (2) preparing a titanium dioxide nanotube layer; (3) preparing rare earth doped metal organic framework particles; and (4) preparing a coating containing hydroxyapatite and rare earth doped metal organic framework particles. The composite material for the implant can overcome the defects of poor antibacterial property and the like of the existing titanium material on the premise of having good biocompatibility similar to that of an existing titanium material.

Description

technical field [0001] The invention relates to the interdisciplinary technology of chemistry, material science and biomedicine, in particular to a composite material for implants and a preparation method thereof. The composite material for implants comprises a titanium metal base layer, a titanium dioxide nanotube layer, and a coating comprising hydroxyapatite and rare earth-doped metal-organic framework particles. Background technique [0002] Due to their good biocompatibility and mechanical strength, titanium and its alloys have been used as bone substitutes and orthopedic implants for decades. However, due to the lack of antibacterial properties of titanium and titanium alloys, and the disadvantages of easy surface corrosion and low surface roughness, it is easy to cause postoperative inflammation, bacterial infection, stress deformation and poor bone formation around the implant, which inhibits its development. further application. [0003] At present, various surfac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/30A61L27/32A61L27/54A61L27/50C25D11/26C25D15/00
CPCA61L27/06A61L27/306A61L27/32A61L27/54A61L27/50C25D11/26C25D15/00A61L2430/02A61L2300/102A61L2300/404A61L2300/606A61L2400/12
Inventor 黄卫民倪翔张子祺
Owner 广东湛美生物医药技术有限公司
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