The invention provides a motion control simulation method of variable rotation center of a dynamically positioned ship, which calculates the speed of the center of rotation of the ship and the switching matrix of the center speed of the ship through the position of the center of rotation in the coordinate system of the ship, and calculates the motion state of the center of rotation. Calculate the expected motion state, calculate the relative position coordinates of each propeller, calculate the new propeller position layout matrix, calculate the expected thrust and expected rotation azimuth of each propeller, and synthesize the thrust actually output by the propeller to the center of rotation , form a resultant force, calculate the motion state at the center of rotation, calculate the position and attitude in the northeast coordinate system, and calculate the position of the center of rotation. The invention can effectively simulate tasks such as fixed-point positioning and path tracking after the dynamic positioning ship changes the rotation center, reduces the simulation error, can truly reflect the actual situation, and can provide motion control for the actual dynamic positioning system variable rotation center provide technical support.