The invention provides a temperature-controllable pressure-controllable oil-gas-water-solid multi-phase pipeline simulation device, which is composed of a vacuum pump, a valve, a vacuum gauge, a pressure gauge, a gas flow meter, a vacuum buffer tank, a natural gas compressor, and a visible rotating pipeline , temperature sensor, visual window, gas mass flow controller, reaction kettle, liquid filling pump, liquid storage tank, standpipe, liquid flow meter, gas cylinder, circulation pump, balance, low temperature box, temperature control water bath; the device is divided into It is a gas, liquid, and solid phase supply system, temperature control and heat preservation system, pressure control system, purge and vacuum system, and pipeline flow system. The device can simulate the multiphase flow of oil, gas, water and solid multiphase fluids and gas and liquid single-phase fluids in horizontal, vertical and inclined pipes under certain pressure and temperature conditions. It has simple structure, wide application range and easy operation. The advantage of convenience.