A new use of a molecule comprising at least one moiety which is a biologically active protein and at least one moiety capable of binding to a serum albumin of a mammal is provided, for preparation of a medicament which elicits no or a reduced immune response upon administration to the mammal, as compared to the immune response elicited upon administration to the mammal of the biologically active protein per se. Also provided is a method of reducing or eliminating the immune response elicited upon administration of a biologically active protein to a human or non-human mammal, which comprises coupling the polypeptide to at least one moiety capable of binding to a serum albumin of the mammal.
The invention relates to a method for determining the threshold value of screens which enable an evaluation of a sound coupling during the ultrasound testing of a series of spot welding joints of a selected type. Initially, a geometrical minimal thickness dMin is established for the spot welding joints. At least one echo of the front surface (entrance echo) is received in addition to one echo of the first reflection on a rear wall of the spot welding joint (first rear wall echo) and at least one further (n-th) rear wall echo. The propagation time tMin of the ultra sound pulse is defined for the path to the front surface to the rear wall and back to the front surface at a minimal thickness dMin and a propagation time tT for the total thickness. A first screen (B1) is set for the signal of the rear wall echo, starting at a moment in time t1S=tE+tMin−tSA and ending at a moment in time t1T=tE+tT+tSE, whereby tSA and tSE are additional small security measures. An n-th screen is correspondingly determined for the n-th rear wall echo. The testing head is oriented differently.