The invention discloses a process method for single-side welding and double-side forming of Q500qENH weathering resistant steel in an alpine region, which can overcome the adverse effect of the alpine environment of the plateau on the welding performance and improve the low-temperature toughness, crack resistance and weather resistance of a welding joint, so that the welding joint with good mechanical properties and weather resistance is obtained, large-span, heavy-load, high-strength, high-toughness and high-weather-resistance bridge steel is welded in a matched manner in a plateau alpine region, meanwhile, preheating before welding and heat treatment after welding are not needed, the production efficiency is improved, and the energy consumption is reduced.