Disclosed herein are an apparatus and a method for mixing and / or mulling a sample, the apparatus comprising at least one container made of a flexible material and containing a sample, means for holding the container, and means for impacting the container, wherein the means for holding and the means for impacting are movable relative to each other, and wherein the means for holding, the means for impacting, and the container are arranged such that the means for impacting and the container can repeatedly collide, whereby an energy of collision can be imparted to the sample, thereby mixing and / or mulling the sample. Also disclosed is an assembly for performing high throughput experiments including the apparatus for mixing and / or mulling a sample and an extruder configured to receive a sample weighing less than 100 grams.