54results about How to "Detection sensitivity" patented technology

The invention provides methods, compositions, apparatus, and a computer data retrieval system for conducting proteomics.

Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.

Spherical, transparent silica gel particles with a high luminescence that are produced through the encapsulation of one or more different luminescent substances in a silica gel matrix. By varying the concentration of the luminescent substances and through the encapsulation of substances with different emission frequencies, the particles can be used as multiplex coding and marker systems in bioanalytics and diagnostics.

A display device that achieves both high detection sensitivity of the touch sensor unit and smooth input on the touch sensor unit is provided. A method for driving a display device includes a first period and a second period. The display device includes pixels, a gate driver, and a touch sensor unit. The touch sensor unit detects a touch in the first period and stops detecting a touch in the second period. The gate driver supplies signals to some of the pixels and does not supply signals to the other pixels in the second period.

A photomask blank has a light-shielding film composed of at least two layers on a transparent substrate. The light-shielding film includes a light-shielding layer made of a material mainly containing tantalum nitride and containing less than 62 at % nitrogen. The material is capable of being dry-etched with a chlorine-based gas containing no oxygen. The light-shielding film further includes a front-surface antireflection layer formed on the light-shielding layer and made of a material not capable of being dry-etched with a chlorine-based gas, but capable of being dry-etched with a fluorine-based gas.

A solder-joint detection circuit uses a resistive bridge and a differential detector to detect faults in the solder-joint network both inside and outside the digital electronic package during operation. The resistive bridge is preferably coupled to a high supply voltage used to power the package. Resistors R1 and R2 are connected in series at a first junction between the high and low supply voltages and a resistor R3 is coupled to the high supply voltage and connected in series with the resistance of the solder-network at a second junction. The network is held at a low voltage on the die. The detector compares the sensitivity and detection voltages and outputs a Pass / Fail signal for the solder-joint network.

The invention discloses a method for preparing a fluorescence biosensor and an application of the fluorescence biosensor. Under the light-emitting effect of copper nano particles with polythymine-carried single-stranded DNAs used as the template, the phenomenon that light induction electron transfer is generated between G-four-linked bodies and the copper nano particles, and thus emitted light of the copper nano particles is quenched is utilized, so that the copper nano particles based on the thymine-carried single-stranded DNAs used as the template and a light induction electron transfer system are prepared for establishing the fluorescence sensor. The principle that targets (HBV genes) and probes are combined to form the system of a compact structure, so that the distance between the G-four-linked bodies and the copper nano particles is zoomed out is adopted, and the sensitivity and specificity of the HBV genes are detected.

The present invention provides a high frequency power amplifier circuit capable of obtaining sufficient detection output even in a range where a request output power level is low and performing a desired output power control by a control loop with the detection output in a radio communication system which detects output power and performs feedback control. An output power detection circuit which detects the level of output power on the basis of an AC signal supplied from a final amplification stage of a high frequency power amplification circuit via a capacitive element has a circuit configuration such that in a state where the output power control voltage is lower than a certain level, current (Isu) according to the output power control voltage is generated and supplied to the output power detection circuit, and detection sensitivity of the output power detection circuit improves according to the current.

A split type magnet device for a high-sensitivity NMR apparatus to be used for solution analysis generates a remarkably uniform magnetic field at the center portion of the magnet device used for determining a sample. The magnet device for NMR apparatus has first multilayer coils and second multilayer coils, which face each other with a predetermined distance being provided therebetween, each of pairs of the first and the second coils being substantially coaxial with respect to a central axis, and each of layers of each of the first and the second multilayer coils having at least one coil. An energizing current of at least one of the coils constituting an innermost layer of each of the first and the second multilayer coils is in a minus direction, when an energizing current of the coil used for generating a main magnetic field for NMR detection in the vicinity of a center portion of the apparatus is in a plus direction.

The invention provides a fluorescent biosensor, a preparation method and an application of the fluorescent biosensor to detect an organic phosphorus pesticide. The luminous effect of copper nanoparticles which take polythymine-carrying single-chain DNA as a template is used, tyrosinase is used to quench the copper nanoparticles, and the organic phosphorus pesticide is added to inhibit the activityof tyrosinase, thereby preparing the fluorescent biosensor which is constructed based on copper nanoparticles which take polythymine-carrying DNA as a template, tyrosinase and the organic phosphoruspesticide. The fluorescent biosensor can detect the organic phosphorus pesticide with sensitivity and specificity. Compared with a fluorescent biosensor in the prior art, the fluorescent biosensor adopts unmarked DNA, is simple to operate and low in cost, and is free of any chemical mark and modification. Through enzymatic activity inhibition, a sensor capable of detecting an organic phosphorus pesticide can be prepared. The result shows that the sensor can detect the organic phosphorus pesticide with the sensitivity being 0.1 ng / L to 1000 ng / L. The fluorescent biosensor is simple to operate,high in sensitivity and low in detection limit.

A power amplification device includes a BTL amplification circuit including a first amplification circuit and a second amplification circuit, the first amplification circuit including a first output transistor, a first power detection circuit, a second output transistor, and a second power detection circuit, the second amplification circuit including a third output transistor, a third power detection circuit, a fourth output transistor, and a fourth power detection circuit, a first comparator which compares output values of the first and fourth power detection circuits, and a second comparator which compares output values of the second and third power detection circuits.

There is provided a microdevice for biomaterial detection, including a passive micromixer to mix a biomaterial, a first probe, and a second probe; a magnetic separation chamber connected with the passive micromixer; and a capillary electrophoresis channel connected with the magnetic separation chamber.

An ultrasonic sensor is disclosed. The ultrasonic sensor includes a plurality of sensor elements arranged in an array. Each sensor element includes an ultrasonic sensing element and an acoustic matching member. The ultrasonic sensor further includes a bonding member having a thickness approximately equal to a space interval between adjacent ultrasonic sensing elements. The bonding member adhesively fixes the plurality of sensor elements, and includes a portion contacting each ultrasonic sensing element. An elastic modulus of the portion is smaller than that of each ultrasonic sensing element.

The invention relates to a fluorescence sensor as well as a preparation method and application of the sensor, and a method for detecting Heparin molecules. The fluorescence sensor consists of SG fluorescent dye and non-marked DNA (Deoxyribose Nucleic Acid) configuration transition, and by utilizing the static function of the Heparin molecules with Coralyne, the fluorescence sensor is applied to detection on target Heparin molecules. The preparation method comprises the following steps: dissolving DNA in a Tris-HCl buffer solution, adding SG into the buffer solution containing DNA, and culturing, further adding a prepared Coralyne solution, culturing so as to obtain a mixture of DNA-SG-Coralyne, adding the a prepared Heparin solution into the buffer solution containing the mixture of DNA-SG-Coralyne and culturing, thereby obtaining the sensor based on SG fluorescent dye and the non-marked DNA configuration transition. The preparation method of the fluorescence sensor adopts non-marked DNAs and is easy to operate, low in cost and capable of avoiding any chemical marking or modification. The fluorescence sensor has the characteristics of easiness in operation, high sensitivity and low detection limit.

A power amplification device includes a BTL amplification circuit including a first amplification circuit and a second amplification circuit, the first amplification circuit including a first output transistor, a first power detection circuit, a second output transistor, and a second power detection circuit, the second amplification circuit including a third output transistor, a third power detection circuit, a fourth output transistor, and a fourth power detection circuit, a first comparator which compares output values of the first and fourth power detection circuits, and a second comparator which compares output values of the second and third power detection circuits.

A physical quantity sensor includes a movable flat plate having a plurality of openings passing therethrough that is swingable around an axis of rotation, a support substrate linked to the flat plate via a column to suspend the movable flat plate over the support substrate via a gap, and a protrusion protruding toward the movable element. In a plan view, the openings are excluded from a D / 2-width annular range surrounding the outer circumference of the protrusion, where D is the maximum outer diametrical dimension of the protrusion.

An acceleration sensor outputs a walk signal having a charge corresponding to a walk. The walk signal is converted by charge-voltage conversion means into a voltage walk signal, removed of noise by filter means, amplified by amplification means and converted by binarization means into a digital signal, followed by being inputted to a CPU. The CPU performs open-close control of switches, such that the walking pitch, calculated based on the walk signal, comes within a predetermined walking pitch range stored in the storage means thereby controlling the conversion gain of the charge-voltage conversion means and controlling the walk detection sensitivity properly.

The invention belongs to the technical field of gene engineering, and particularly relates to a TCR primer group for specifically recognizing an EBV peptide fragment with immune typing of HLAA02 and application of the TCR primer group. The primer group provided by the invention is designed according to HLAA02 typing and TCR of an EBV virus antigen peptide fragment FLYALALLL, and comprises one or more of TCR primer pairs with the loci of L2-1, L2-2, L2-3, L2-5, L2-6, L2-9, L2-10, L2-11, L2-12, L2-13, L2-16, L2-19, L2-23, L2-24 and L2-25. The sequences of the primers disclosed by the invention are as shown in SEQ ID NO. 1-30. The primer group disclosed by the invention can be used for specifically recognizing the TCR of the EBV antigen peptide fragment FLYALALL in the body of an HLAA02 typing patient.

There is provided a photoconductive element capable of increasing an output and detection sensitivity by increasing resistivity as the entire element. The photoconductive element is a photoconductive element capable of generating or detecting an electromagnetic wave when light is emitted thereto. The photoconductive element includes a photoconductive layer having a semiconductor layer whose resistivity changes when light is emitted to thereby generate or detect an electromagnetic wave; and a plurality of electrodes provided in contact with the semiconductor layer. The resistivity of the semiconductor layer changes in a thickness direction of intersecting a surface of the semiconductor layer contacting the electrodes. Assuming that the semiconductor layer includes a first region and a second region which is farther away from the electrodes in the thickness direction than the first region, the resistivity in the first region is greater than the resistivity in the second region.

Mass tagging methods are provided that lead to mass spectrometer detection sensitivities and molecular discriminations that are improved over other methods. In particular the methods are useful for discriminating tagged molecules and fragments of molecules from chemical noise in the mass spectrum. These mass tagging methods are useful for oligomer sequencing, determining the relative abundances of molecules from different samples, and identifying individual molecules or chemical processing steps in combinatorial chemical libraries. The methods provided are useful for the simultaneous analysis of multiple molecules and reaction mixtures by mass spectrometric methods.

An optical coherent tomographic imaging system includes means for introducing a 180-degree phase inversion in the interference fringes, and generating a two-peak shape point spread function (PSF) in the frequency domain for the interference-based tomographic imaging system. The system further includes means for achieving sharper resolution than the diffraction-limited spectral bandwidth in the tomographic imaging system through subtracting the two-peak shape from the original Gaussian PSF. Means are provided for removing the ghost fringes in the tomographic imaging system, which is introduced by the self-interference between the different layers of the sample arm. The apparatus is configured to realize the real-time super-resolution swept-source optical coherent tomography (OCT) such that the sensitivity of the system is enhanced by suppressing the noise floor in the frequency domain, as well as removing the ghost fringes.

The invention relates to a method and device for realizing a driving recording effect through a mobile phone. The method comprises the steps of obtaining driving parameters and / or a voice starting instruction; judging whether to start a driving recording mode of a camera module of the mobile phone or not according to the obtained driving parameters and / or the voice starting instruction; and starting the camera module to photograph images for driving recording after the driving recording mode is carried out. The method and the device have the advantages that when the mobile phone detects that a vehicle is started or is in a driving state, and the voice starting instruction preset by the user is detected, the driving recording mode is started, and the camera module is started to photograph images, thereby recording the driving road condition behind and of two sides of the vehicle in the driving process; and therefore, the user does not need to purchase a new driving recorder.

The invention discloses a biological colorimetric sensor, a preparation method and application in glucose detection. The preparation method comprises the following steps: putting a mixture of a glucose solution and a glucose oxidase solution into a buffer solution, performing culture, adding a methylene blue solution, uniformly mixing, and further adding an ssDNA (Single-Stranded DeoxyribonucleicAcid) buffer solution, thereby obtaining a mixed solution, namely the biological colorimetric sensor. Compared with the prior art, the biological colorimetric sensor preparation method disclosed by the invention is low in cost and simple to design, the colors of solutions can be changed with glucose of different concentrations, and the change can be read with naked eyes. Under interaction of methylene blue and single-chain DNA, and by virtue of conformation interconversion of the single-chain DNA with polycytosine, a sensor for detecting glucose can be prepared. Results show that the sensor iscapable of sensitively detecting glucose with the concentration of 5mu M to 0.8mM, and also is simple to operate, high in sensitivity and lo win detection limit.

The invention belongs to the technical field of gene engineering, and particularly relates to a fluorescent PCR primer group for specifically recognizing a TYGPVFMSL peptide fragment and application thereof. The primer group disclosed by the invention is designed according to HLAA24 typing and TCR of an EBV virus antigen peptide fragment TYGPVFMSL, and comprises one or more of TCR primer pairs of which the loci are L24-3, L24-5 and L24-13. The primer sequences provided by the invention are as shown in SEQ ID NO.1-6. The primer group provided by the invention can specifically recognize the TCR of the EBV virus antigen peptide fragment TYGPVFMSL in the body of an HLAA24 typing patient, and provides a basis for tracking and monitoring TCR-T cell drugs in the body of the patient.