42 results about "VEGFR Inhibitor" patented technology

The present invention relates to VEGFR inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The said derivatives may further act as HDAC inhibitors.

The invention relates to an anti-cancer composition with synergistic effect, specifically a composition comprising an effective amount of at least one VEGF / VEGFR inhibitor and dopamine. The composition provided by the invention can obviously inhibit the growth of tumor cells, substantially reduce the use of anticancer drugs, and reduce the treatment risk and cost, and has broad application prospects.

The invention discloses the use of an anti-PD‑1 antibody combined with a VEGFR inhibitor in the preparation of a drug for treating cancer.

The present invention relates to methods, compositions, and kits for using placental growth factor (PLGF) as an informative biomarker in determining the clinical benefit to renal cell carcinoma patients by treatment with a VEGFR inhibitor and an Ang2 inhibitor.

The invention relates to pharmaceutical composition of a VEGFR inhibitor and a preparation method of the pharmaceutical composition. Specifically, the invention relates to composition comprising N-[4-(1-cyanocyclopentyl)phenyl]-2-(4-pyridylmethyl)amino-3-pyridinecarboxamide with the particle size D90 smaller than about 10 mu m and a preparation method of the pharmaceutical composition. Compared with a commercial preparation, the pharmaceutical composition has improved individual difference.

The present invention includes methods for treating a proliferative disorder by blocking both PDGFR and VEGFR signaling comprising a therapeutically effective amount of crenolanib or salt in combination with a VEGF/VEGFR inhibitor that is not axitinib wherein the crenolanib, VEGF/VEGFR inhibitor that is not axitinib are provided at least one of sequentially or concomitantly, in a subject for use in the treatment of the proliferative disorder, wherein the subject is a human subject.

The invention discloses an application of a VEGFR inhibitor in preparation of an anti-Alzheimer's disease medicine. The VEGFR inhibitor is axitinib and an analogue thereof. It is found that axitinib has an unexpected curative effect on Alzheimer's disease, and Alzheimer's disease model animal in-vivo experiments prove that after administration of axitinib, beta-amyloid protein deposition in the brain of a model animal is significantly reduced, the content of acetylcholin esterase is reduced, the oxidative stress level and inflammatory response of the lesion part of the model animal are relieved, the learning and memory ability and learning and memory behaviors of the model animal on space and direction are improved, and the curative effect is obviously higher than that of a clinical first-line treatment drug donepezil. The axitinib and the analogue thereof provide a new means for clinical treatment of the Alzheimer's disease, and the axitinib and the analogue thereof are high in human body safety, low in price and easy to prepare. According to the invention, non-intracranial administration mode is adopted, safety is high, administration is convenient and fast, and patient compliance is high. The application of a VEGFR inhibitor in preparation of an anti-Alzheimer's disease medicine has wide market prospects and great social significance.

The invention relates to an anti-cancer composition with a synergistic effect. The composition comprises at least one kind of VEGF/VEGFR inhibitor with effective dose and 2-position (containing an N-aryl piperazine structure) substituted quinazoline derivative composition. The composition can significantly inhibit the growth of tumour cells and reduce the using amount of anti-cancer drugs, the treating risk and cost, and the composition has wide application prospect.

The disclosure relates to pharmaceutical combinations. Specifically, the invention provides application of a PD-1 antibody combined with paclitaxel and a VEGFR inhibitor such as apatinib in preparation of drugs for treating triple negative breast cancer, the combined treatment scheme shows better disease control rate and objective response rate, embodies a synergistic effect of combined medication, and significantly improves the curative effect of immunotherapy.

The invention relates to a VEGFR inhibitor and blood pressure reducing medicine composition. The composition is a composition of Axitinib and Losartan. The medicine composition lies in combined use ofAxitinib and Losartan, and in vivo experimentation on animals confirms that compared with single medicine of the Axitinib, the composition not only has notable treatment effects on carcinoma of kidney, but also notably reduces side effects of elevation of blood pressure, liver enzyme, elevation of serum creatinine caused by the Axitinib. The VEGFR inhibitor and blood pressure reducing medicine composition is controllable for side effects of antitumor drugs for targeting VEGFR, and a new research thought train is provided for clinical application of target medicines.