50 results about "Tryptophan Metabolism" patented technology

Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and tryptophan 2,3 dioxygenase; treating immunosuppression; treating a medical conditions that benefit from the inhibition of tryptophan degradation; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.

The invention relates to a preparation method of tryptanthrin compound and a new application of tryptanthrin compound in preparing indoleamine-2,3-dioxygenase (IDO) inhibitor, in particular to an application of tryptanthrin compound in preparing IDO inhibitor and in preparing medicine for preventing and / or treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO. The structure of the tryptanthrin compound is shown in formula A in the description, wherein R1 and R2 are respectively and independently selected from hydrogen, nitryl, C1 to C5 alkyl, halogen or piperazinyl. The tryptanthrin compound can be used as an IDO inhibitor with high activity and is used for treating diseases having pathological characteristics of tryptophan metabolic disturbance mediated by IDO such as tumor, cancer, Alzheimer disease, autoimmune disease, cataract, mental block, tristimania, anxiety neurosis, acquired immure deficiency syndrome (AIDS) and other serious diseases, and as a medicinal resource which is very difficult to get, the tryptanthrin compound has good potential on researching and developing new medicine.

The invention discloses an application of azatryptanthrin derivatives as IDO1 (indoleamine 2,3-dioxygenase) and / or TDO (tryptophan 2,3-dioxygenase) inhibitors. The structure of the derivatives is shown as the general formula (I) in the description, wherein substituents are defined in detail in the description. The compounds shown as the general formula (I) have an inhibition effect on IDO1 and / or TDO and can be used for treating diseases having pathological characteristics of IDO1 and / or TDO mediated tryptophan metabolism, and the diseases include but are not limited to tumors, autoimmune diseases, infectious diseases, Alzheimer disease, depression and anxiety disorder.

The invention discloses indazole compounds as shown in a formula (i) or (II) which is described in the specification, and a preparation method thereof, and application of the compounds as IDO inhibitors. The compounds provided by the invention can be used for preventing and / or treating a plurality of diseases, such as Alzheimer's disease, cataract, infections related to cellular immune activation,autoimmune diseases, AIDS, cancers, depression, the metabolic disorder of tryptophan or the like.

The invention discloses the use of azatryptanthin derivatives as IDO1 and / or TDO inhibitors. The derivatives are represented by the general formula (I), wherein the definition of each substituent is detailed in the description. The compound represented by the general formula (I) has inhibitory effect on indoleamine-2,3-dioxygenase 1 (IDO1) and / or tryptophan-2,3-dioxygenase (TDO), and can be used For the treatment of diseases with pathological features of tryptophan metabolism mediated by IDO1 and / or TDO, including but not limited to tumors, autoimmune diseases, infectious diseases, Alzheimer's disease, depression, anxiety.

The invention discloses a compound capable of inhibiting IDO, its preparation method and its application. Its general structural formula is as follows: in, selected from a cis isomer, a trans isomer or a mixture of cis and trans isomers; R 1 and R 2 each independently selected from any one of hydrogen atom, halogen, alkyl, alkoxy or haloalkyl; R 3 Any one selected from cyclopentyl, cyclohexyl, piperazinyl, piperidinyl, R 3 The substitution positions are 1, 2, 1, 3 or 1, 4; m and n are integers of 0-5 respectively. The compound capable of inhibiting IDO provided by the present invention has strong inhibitory activity on IDO, and can be used to prepare IDO inhibitors to prevent and / or treat diseases with pathological characteristics of IDO-mediated tryptophan metabolic pathway, and has Very good application prospects.

The present invention relates to an N-benzyl tryptanthrin derivative, and preparation method and use thereof. The N-benzyl tryptanthrin derivative of the present invention is characterized in that the derivative has a structural general formula as represented by formula 1, wherein each group is defined as in the specification. The preparation method of the compound is simple, has mild conditions and high yield, and is suitable for industrial production. The N-benzyl tryptanthrin derivative has good indoleamine-2,3-dioxy-genase (IDO) inhibitory activity, and can be used for treating diseases having the pathological feature of IDO-mediated tryptophan metabolism.

The invention discloses an L-tryptophan producing bacterial strain, a gene engineering construction method for the L-tryptophan producing bacterial strain and a method for producing and preparing L-tryptophan by a fermentation method. Genes relevant to an L-tryptophan metabolic pathway are mutated and deleted by the gene engineering measure to promote metabolism disorder of the L-tryptophan, so that the L-tryptophan has high yield; simultaneously, the metabolic flow of the L-tryptophan is reinforced by gene integration or by overexpressing the genes relevant to the L-tryptophan metabolic pathway through a proper expression vector; finally, a large quantity of L-tryptophan can be accumulated in the fermentation solution by fermenting.

The invention discloses 1H-indazole-4-amine compounds and further discloses a preparation method of the 1H-indazole-4-amine compounds and an application of the 1H-indazole-4-amine compounds as an IDO (indoleamine 2,3-dioxygenase) inhibitor. The 1H-indazole-4-amine compounds can be used for preventing and / or treating various diseases such as Alzheimer's disease, cataract, cellular immune activation associated infection, autoimmune disease, acquired immune deficiency syndrome, cancer, depression or tryptophan metabolic disorder.