38 results about "Triazene Compound" patented technology

The invention discloses a method for preparing dibenzothiophene derivatives. The method comprises the following steps of: synthesizing dibenzothiophene derivatives with chemical formulas of (I), (III) or (IV) from methylmercapto-containing triazene compounds in an organic solvent under catalysis of lewis acid, wherein R1 is ethoxycarbonyl, cyano, hydrogen or acetyl; R2 is chlorine or methyl; R3 is chlorine; R4 is halogen, methyl or methoxyl; and R5 is styryl. The preparation method is simple and mild in reaction conditions and has wide application prospects in the industries of fine chemical engineering and pharmacy.

To provide a method for enhancing analysis sensitivity of bio-related molecules in mass spectrometry. To provide a method for rapidly and conveniently analyzing biological acid molecules using the method of enhanced analysis sensitivity in mass spectrometry.A method of preparing a bio-related molecule to be subjected to mass spectrometry, in which at least a part of acid group(s) is esterified, comprising reacting a bio-related molecule comprising an acid group(s) with a triazene compound to esterify at least a part of said acid group(s). A method of analyzing bio-related molecules comprising reacting a bio-related molecule comprising an acid group(s) with a triazene compound to esterify said acid group(s), and then subjecting said bio-related molecule having an esterified acid group(s) to mass spectrometry.

The invention relates to a di-triazene compound, in particular to a preparation method and an application of 3,3'-diethoxy-4,4'-di(8-hydroxy-5-quinoline ammonia azo)azobenzene, which is used for solving the problem of non-ideal sensitivity of a reagent for detecting heavy metal zinc ions existing in the prior art. The molecular structural formula of the 3,3'-diethoxy-4,4'-di(8-hydroxy-5-quinoline ammonia azo)azobenzene is shown in the specifications. The 3,3'-diethoxy-4,4'-di(8-hydroxy-5-quinoline ammonia azo)azobenzene is characterized in that: 5-amino-8-oxychinolin and 3,3'-diethoxy-4,4'-diamido-azobenzene with fluorescent characteristics are combined together to construct a di-triazene reagent with a larger conjugated system, so that the sensitivity and fluorescent characteristic of the reagent are enhanced. The 3,3'-diethoxy-4,4'-di(8-hydroxy-5-quinoline ammonia azo)azobenzene can be used for detecting zinc ions in an alkaline medium.

The present invention relates to novel triazene compounds, to a process for their preparation, to pharmaceutical compositions comprising them, and to the use thereof in the treatment of cancer diseases in humans. The novel triazene compounds are distinguished, as compared with the known triazene compounds, by improved activity while at the same time having reduced toxicity, that is to say by fewer side-effects.

The invention relates to a triazene compound 1-(8-quinoline)-3-(2-pyridyl)-triazene (QPyT) which contains heterocycle. The preparation method of the invention comprises the steps: diazotizing 8-amino quinoline by using sodium nitrate under acidic condition and reacting with 2-aminopyridine in alcoholic solution. The compound is not only a good visualization reagent, but also a fluorescent reagentwith high sensitivity and good selectivity, which can be used for fluoroscopic examination of metal ion, in particular for the examination of Pb (II) in alkaline medium.

The present invention relates to a heterocyclic di-triazene compound, di-(8-quinoline diazoaminoazobenzene)-biphenyl (BQDADB). 8-aminoquinoline is treated through diazotization by sodium nitrite under the acidic conditions and then reacts with benzidine in the alcohol solution; thus the compound can be prepared. The compound can not only be used as an excellent chromogenic agent, but also can be used as a fluorescent reagent with high sensitivity and high selectivity. And the compound can be used for testing the fluorescence of metal ions, in particular testing the Cu(II) in the alkaline medium.

The invention discloses a triazene compound, a preparation method, and a method for determination of a cadmium content. A structural formula of the triazene compound is as shown in the specification, wherein the name of the triazene compound is 1-(p-acetylbenzole)-3-(quinaldine)-triazene. The preparation method comprises the steps of diazonium salt synthesis, diazonium salt coupling and product purification. The method for the determination of the cadmium content comprises the steps of sample digestion, cadmium enrichment, complex reaction and absorbance determination. The triazene compound is a new compound synthesized for the first time; for the determination of the cadmium content, solid phase extraction is adopted to enrich cadmium, a lower cadmium content in a sample can be tested, interfering ions are few, and the contrast of absorption positions of a cadmium ion complex and a reagent blank is large, so that the sensitivity of spectrophotometric determination is ensured. The method for the determination of the cadmium content with the triazene compound has the characteristics that a reaction system develops colors rapidly, the system is stable, the use amount of an organic solvent is small, the operation is safer, and the pollution to an environment is small.

The invention belongs to the technical field of double triazene compounds and provides 3,3'-dimethylthio-4,4'-bis(2,6-dichloro-4-nitrophenyl diazoamino) biphenyl, a preparation method and an application in order to solve the problems that when an existing triazene reagent is used for detecting heavy metal ions through photometric analysis, interference from coexisting ions is strong, sensitivity and selectivity are not ideal enough and the existing triazene reagent cannot be taken as a fluorescent reagent for fluorescence detection of the heavy metal ions. 3,3'-dimethylthio-4,4'-diaminodiphenyl and 2,6-dichloro-4-nitrophenyl are linked together through a triazene functional group -N=N-NH-, and a prepared reagent is not only a photometric analysis reagent with good sensitivity and selectivity, but also is a fluorescence analysis reagent with a high fluorescence characteristic. The sensitivity of the reagent for measuring mercury with a photometric method is improved; the reagent is a fluorescent lead (II) measurement reagent with good sensitivity and selectivity; the allowed coexistence number of common interfering ions is greatly increased; a synthetic method is simple, conditions are mild, and complexes formed by a solid reagent and a reagent solution with mercury are all stable.

The present invention relates to a bis-triazene, in particular to a 3.5-bis-(4-nitrobenzenediazoamino) benzoic acid and the preparation method thereof. The molecular structure is shown by the formula below, the preparation method includes the following procedures that: 1,3-diamino-benzoic acid is dissolved with HCl solution, NaNO2 is taken, dissolved with water, and added into the solution as above for reaction for about 1-2h to obtain a diazo solution, then p-nitroaniline is dissolved with ethanol, the solution is dripped into the former diazo solution for reaction for 1.5h to obtain a hennadeposit, which is allowed standing overnight, filtrated to obtain a deposit, which is rinsed with anhydrous ethanol and water, and then dried to obtain the brown solid. The substance provided by the present invention can be adopted as the fluorescence agent for heavy metal ion and the luminosity analytical developer.

The invention relates to bis-triazene compound, in particular to a method for preparing 3, 3'-dihydroxy-4,4'-di(1,1'-dinaphthylamine azo group) azobenzene and application thereof. A molecular structural formula of the 3,3'-dihydroxy-4,4'-di(1,1'-dinaphthylamine azo group) azobenzene is shown as an illustration below. The method is characterized in that naphthylamine and 3,3'-dihydroxy-4,4'- dinaphthylamine azo group which have a fluorescent characteristic are combined together through a diazotization reaction and a coupling reaction, so that a conjugated system of the compound is increased to be a ditriazene reagent, and the fluorescent characteristic of the reagent is improved. The reagent is a fluorescent reagent which is high in sensitivity of detecting Ag (I) in an alkaline medium and good in selectivity. Therefore, the reagent is not only a good photometric analysis color reagent but also a fluorescent analysis reagent which is good in sensitivity and selectivity and low in detection limit, and can be used for detecting silver ions in the alkaline medium.

The invention relates to a bis-heterocyclic triazene compound, and specifically relates to a 2,2'-bis(2-hydroxy-4-sulfonic-1-naphthylamine azoxyl)-5,5'-dimethyl-4,4'-bithiazole and a preparation method thereof. The preparation method comprises the following steps of: (1) preparation of 2,5-dibromohexanedione; (2) preparation of 2,2'-diamino-5,5'-dimethyl-4,4'-bithiazole; (3) preparation of 5,5'-dimethyl-4,4'-bithiazole-2,2'- bis-diazonium salt; (4) preparation of an objective product BHSNAADMBT. The technical scheme of the invention connects bithiazole heterocycle and naphthalene ring derivative with fluorescence property together to synthesize a reagent with double functional-analytical groups and large steric hindrance; and the compound of the invention not only has high reaction sensitivity with metal ions, but also has good selectivity. The reagent is a good photometric analysis developer and a novel fluorescence analytical reagent with high sensitivity and good selectivity as well.