The invention discloses a method for synthesizing a
biphenyl compound by using
phenol as a
raw material in the technical field of organic
chemical synthesis, which comprises the following steps: carrying out a mixed reaction process on
phenol or substituted
phenol, alkali and 50-90%
ethanol aqueous solution, slowly introducing
sulfonyl fluoride gas, and carrying out magnetic stirring reaction at normal temperature for 4-12 hours, adding arylboronic acid, alkali and a
palladium catalyst into a round-bottom flask, continuing to react for 6-12 hours at normal temperature, after the reaction is finished, adding a saturated edible
salt solution into the round-bottom flask, carrying out a water
quenching reaction process to obtain a reaction mixture, extracting a
reaction product from the reaction mixture by using
ethyl acetate, combining organic phases, concentrating filtrate, and separating the concentrated filtrate by using
column chromatography to obtain analytically pure
biphenyl or
terphenyl compounds. By using the method, on one hand, the production cost of the
biphenyl compound is reduced, and on the other hand, the method also has a wide application prospect in the aspects of synthesis of natural products, medicines, pesticides, herbicides,
polymer conduction materials,
liquid crystal materials and the like.