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415 results about "Single site" patented technology
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Fusions of cas9 domains and nucleic acid-editing domains
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
Synthesis of poly-alpha olefin and use thereof
InactiveUS7129197B2Improve oxidation stabilityImproved biodegradibilityOrganic chemistry methodsSolid fuelsHydrogenIsomerization
One or more oligomers of an olefin are prepared in the presence of a single-site catalyst. Preferably, the olefin is an α-olefin, and the oligomers are a poly-alpha-olefin (PAO). The PAO so prepared is completely or substantially free of tertiary hydrogen resulting from isomerization. Consequently, the PAO possesses improved biodegradability, improved oxidation resistance, and / or a relatively higher viscosity index. The PAO has many useful applications, such as a component of a lubricant.
Owner:SHELL OIL CO
Single site catalyst for synthesizing polycarbonate
The invention discloses a high-activity catalyst which catalyzing and activating carbon dioxide to perform the copolymerization reaction with alkylene oxide to synthesize polycarbonate. The catalyst is characterized in that the catalyst is a tetradentate schiff base complex contains one or two organic base groups and has single active site initiation and controllable polymerization. The catalyst has the advantages that under milder conditions and at lower concentration of the catalyst, the catalyst can highly and efficiently catalyze the carbon dioxide to make the copolymerization reaction with the alkylene oxide to prepare the polycarbonate, the catalytic efficiency is 10<6>g polymer / mol catalyst, the polymer molecular weight is adjusted in the range of between 5,000 and 500,000, the molecular weight distribution is less than 2, the alternating structure is over 97 percent, and the catalyst can be degraded into small molecule compounds under certain condition. By utilizing the catalyst, the telomerization reaction between the carbon dioxide and two or more than two types of alkylene oxide can be catalyzed to synthesize a polycarbonate telomer with adjusting glass transition temperature.
Owner:DALIAN UNIV OF TECH
Flame retardant composition
Owner:NIPPON YUNIKAA
User Preference Correlation for Web-Based Selection
ActiveUS20130246389A1Web data indexingDigital data processing detailsUser identifierComputer science
A database of user preference information is extracted and compiled from multiple websites by web-crawling robots without cooperation or specific participation by users. Users who interact with a website are frequently required to register and create a login or userID name that uniquely identifies them. Thereafter, when an individual rates an item, it is often recorded and published under their userID name such that other users can see how a specific individual rated the item. Although there is no requirement that a specific user register on different websites utilizing the identical userID, it is extremely common that this practice occurs and the use of identical userIDs on multiple sites is used herein to expand preference analysis beyond a single site. Once the database exists, users can request or be passively offered suggestions that result from preference associations across multiple websites as performed by a preference analysis and suggestion function.
Owner:JOLLY SEVEN SERIES 70 OF ALLIED SECURITY TRUST I
Control of a biological function
InactiveUS20060052341A1Raise transfer toPromote resultsBiocideAnimal reproductionControlled releaseBioavailability
A biological function is controlled via the autonomous delivery of formulations administered at a single site, by determining each of the preferred formulations having efficacy in effecting control of at least one stage of a preferred biological function and includes features of improved permeation of formulations to effect desired bioavailability at a preferred level for a preferred period of time, one or more preferred formulations, in predetermined concentrations, in predetermined quantities, delivered at predetermined time intervals and over predetermined periods, and the delivery regimes for delivery of the formulations to achieve the outcome required. The formulations are delivered via a substance delivery device retained in location at a specific site for at least the delivery period. The device is adapted to house the formulations and the control and delivery apparatus required to effect controlled release of the formulations in accordance with the delivery regime.
Owner:ADVANCED ANIMAL TECH
Methods for nucleic acid editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. In some embodiments, fusion proteins of Cas9 and nucleic acid editing enzymes or enzyme domains, e.g., deaminase domains, are provided. In some embodiments, methods for targeted nucleic acid editing are provided. In some embodiments, reagents and kits for the generation of targeted nucleic acid editing proteins, e.g., fusion proteins of Cas9 and nucleic acid editing enzymes or domains, are provided.
Owner:PRESIDENT & FELLOWS OF HARVARD COLLEGE
System and Method For Virtual Online Dating Services
InactiveUS20110252340A1Input/output for user-computer interactionData processing applicationsSpeed datingSocial web
A system and method for: providing virtual social networking and online dating services; providing collaborative capability between a plurality of members; and providing interactive live multi-point streaming video / audio to the members. The collaborative capability may include auditions. Further, the collaborative capability and interactive live multi-point streaming video / audios may be provided through a single site. The system and method may provide for direct referrals between members and online video dating including speed dating. Further, the social / dating service may also interact with other services.
Owner:THOMAS KENNETH
Latent elastic articles and methods of making thereof
ActiveUS20060246803A1Improve tensile propertiesPersonal careSynthetic resin layered productsPersonal carePolyolefin
A composite nonwoven fabric having latent elasticity is provided having a latently elastic core comprising a first component that includes a thermoplastic elastomer and a second component that includes a single site catalyzed polyolefin, and at least one gatherable facing material laminated to the elastic core. The first and second components may be, for example, in the form of alternating filaments of styrenic block copolymer and single site catalyzed polyolefin or in the form of conjugate filaments having a first section of styrenic block copolymer and a second section of single site catalyzed polyolefin. Also disclosed are methods of making the latently elastic stretch bonded laminates and personal care articles containing the latently elastic stretch bonded laminates.
Owner:KIMBERLY-CLARK WORLDWIDE INC
Floor coverings
InactiveUS6287706B1Small amountControl progressPretreated surfacesThin material handlingPolyolefinAlkene
The present invention relates to sheet materials suitable for use in or as a floor covering. The sheet materials comprise a polyalkene resin in intimate admixture with at least one additive comprising a filler, wherein the polyalkene resin has a relatively narrow molecular weight distribution (MWD) and, a small amount of long chain branching and produced by a single site catalysed polymerisation of at least one, linear, branched or cyclic, alkene having from 2 to 20 carbon atoms. The present invention also extends to processes for the production of such sheet materials and floor coverings.
Owner:FORBO INT
Single-Site Localization via Multipath Fingerprinting
ActiveUS20130172007A1Efficient capturePrecise positioningPosition fixationWireless communicationBase station antenna arraySpacetime
Single-site localization of wireless emitters in a rich multipath environment is presented. The localization method is based on exploiting the spatio-temporal characteristics of the multipath signals, referred to as the multipath fingerprint, as captured by the base station antenna array. The method is applicable to all modern communication techniques such as WiFi and LTE and to any rich multipath environment in indoors and outdoors.
Owner:WAVION
Polymer blends
Owner:NOVA CHEM (INT) SA
Combined presentation of credit information
The present invention is directed to signing up at a single site to receive both personal credit and business information of multiple related individuals and businesses, along with identity theft protection. For example, the invention can provide a website where a user can request to view personal credit information of a married couple and the business credit information of a business associated with the at least one of the couple along with identity theft protection. In this manner, the user can quickly and easily obtain a more complete view of the financial status of an individual, a married couple, or a business in a single location.
Owner:NAV TECH
Elastic films with reduced roll blocking capability, methods of making same, and limited use or disposable product applications incorporating same
A thermoplastic elastomer film demonstrates reduced roll blocking capabilities. The film can either be breathable or nonbreathable. The breathable elastic film includes a core layer of a thermoplastic elastomer and a filled semi crystalline predominantly linear polymer and at least one skin layer of a polyethylene or filled polyethylene. The film core layer includes between about 25 and 70 weight percent filler, between about 5 and 30 by weight percent semi-crystalline linear polymer, and between about 15 and 60 by weight elastomer. The nonbreathable film desirable includes a core of 80-98 percent film volume and a skin of 20-2 percent film volume, with the core including both styrenic block copolymers and single site catalyzed polyethylenes and the skin including single site catalyzed polyethylenes and additional amounts of roll blocking prevention agents (antiblock agents).
Owner:KIMBERLY-CLARK WORLDWIDE INC
Injection molding polymer
An LLDPE produced using a single site catalyst, e.g., an LLDPE produced using a metallocene (m-LLDPE), is preferably used in injection moulding of food packaging material, especially closures for food containers. Such materials have been found to exhibit low levels of migration, typically less than 40 mg / dm<2>, e.g., less than 5 mg / dm<2>, and are particularly suitable for use in packaging foods having a high fat content.
Owner:BOREALIS TECH OY
System and method for digitally monitoring a cable plant
The present invention provides systems and methods for digitally certifying and monitoring a hybrid fiber coaxial (HFC) cable plant. The present invention may be used to automate the characterization of the upstream and / or downstream channels of the cable plant and provide a path for establishing a performance baseline for the cable plant. After certification of the plant, the present invention provides for monitoring of cable plant performance and the use of a performance baseline to provide warnings and alerts prior to system downtime. The present invention also discloses cable plant characterization and monitoring functions being provided from a single site to a plurality of remote cable plant operators.
Owner:AT HOME BONDHOLDERS LIQUIDATING TRUST +1
Broad/bimodal resins with controlled comonomer distribution
Olefin polymers having a conventional comonomer incorporation, a reverse (or partial reverse) comonomer incorporation or a substantially flat comonomer incorporation with a broad, bimodal or multimodal molecular weight distribution are produced under a process using a single site catalyst with the combination of a phosphinimine and / or ketimide compound, and an aluminum compound in a cyclical controlled increase of the ratio of hydrogen to ethylene and controlled or uncontrolled decrease of the ratio of hydrogen to ethylene if plotted as a function of time.
Owner:NOVA CHEM (INT) SA
Method and apparatus for validating and ranking resources for geographic mirroring
InactiveUS20050044226A1Improve usabilityFacilitate proper validationError detection/correctionDigital computer detailsRankingAccessibility
Method and apparatus for validating and ranking of resources that may be switched between a primary system and one or more backup systems at a single site. One embodiment provides a method for ensuring accessibility of one or more disk units by a system, comprising: configuring a disk pool for the system; validating availability of the one or more disk units for the disk pool; verifying that the disk units are at the same site as the system, and selecting one or more valid disk units for the disk pool. The method may further comprise ranking of each disk unit for the disk pool and selecting one or more valid disk units for the disk pool according to ranking.
Owner:IBM CORP
Modular energy harvesting system
InactiveUS20120111004A1Easy to transportReciprocating combination enginesFrom solar energyOrganic Rankine cycleModularity
A modular energy harvesting system. The system preferably uses an organic Rankine cycle heat engine to recover energy from relatively low-temperature heat sources. The system is both modular and scalable. The components are preferably housed within shipping containers so that they may be easily transported by sea and over land. Two or more power harvesting modules may be assembled on a single site to increase the production capacity in a scalar fashion. Each of the integrated units preferably includes an oil-less turbine and motor.
Owner:CONRY RONALD DAVID
Process for the preparation of multimodal polyethylene resins
A two-stage cascade polymerization process for the production of multimodal polyethylene film resins with improved bubble stability is provided. The process comprises polymerizing ethylene or a mixture of ethylene and a C4-8 α-olefin in two reactors arranged in series using a mixed single-site catalyst comprised of a bridged and a non-bridged indenoindolyl transition metal complex to form a multimodal polyethylene resin comprised of a lower molecular weight, higher density component and a higher molecular weight, lower density component.
Owner:EQUSR CHEM LP
Ziegler-Natta olefin polymerization catalysts with single-site center property
The invention relates to novel Ziegler-Natta olefin polymerization catalysts with single-site center property. The catalysts are characterized in that the catalysts are obtained by adopting a one-pot method and adding novel multidentate ligands (I), magnesium compounds, metal compounds and carriers to tetrahydrofuran solution for treatment. Under the action of alkylaluminium or alkylaluminoxane and other cocatalysts, the catalysts can obtain ethylene copolymer and homopolymer products with controllable molecular weight distribution (1.6-40) and uniformly distributed comonomers through high activity. The catalysts can realize catalytic ethylene polymerization, as well as the slurry-process or gas-phase-process homopolymerization or copolymerization of ethylene and 1-olefin, annular olefin, polar monomer and the like.
Owner:SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
Data processing method of database
ActiveCN103116661AImprove writing efficiencyAvoid single point of failureSpecial data processing applicationsData retrievalData node
The invention discloses a data processing method of a database. The data processing method comprises the following steps that a main node servo receives a data processing request of a client, wherein the data processing request comprises a data storage request; the main node server receives data to be stored; the main node server extracts various field values of one field of the data to be stored, calculates corresponding hash values and determines a storage position corresponding to each hash value; the main node server transmits the data to be stored and the hash values to a data node server; the data node server stores line data corresponding to the hash values into a corresponding main hard disc; and the main node server carries out mirror image back-up on the data stored in the data node server, wherein the data processing request also comprises data retrieval requests. The data processing method of the database, disclosed by the invention, is high in data processing efficiency and larger in capacity, and avoids the happening of single-site faults in a cluster.
Owner:GUANGDONG EASTONE CENTURY TECHNOLOGY CO LTD
A software controlled access control door controller
ActiveUS20080094171A1Minimal disruptionImprove security levelElectric signal transmission systemsDigital data processing detailsDistributed intelligenceCard reader
The present invention is an access control door controller which utilizes three relays, 16 alarm inputs, tamper switch, a Weigand reader, a RS 232 reader and a IP core module to enable access control alarm monitoring, inter locking of doors and / or energy management for a room with the help of a software. The present invention utilizes a distributed communication (peer to peer) thus creating a door access controller System network with a truly distributed intelligence permitting exchange of information between all controllers which may be situated in a single site or over multiple sites connected on a common network. The full system can be configured on the widely used TCP / IP network thus avoiding the need for extensive wiring traditionally required for Access Control System. The controller, with its associated software can support multiple types of readers and can directly interface IP cameras for an integrated TCP / IP based Access Control / CCTV Solution.
Owner:INGERSOLL RAND NEXIA INTELLIGENCE
Supported antistatic polymerization catalyst
ActiveUS7476715B2Organic-compounds/hydrides/coordination-complexes catalystsCatalyst activation/preparationAntistatic agentGas phase
The use of high activity “Single Site” polymerization catalysts often causes the fouling of polymerization reactors. The problem is particularly acute with gas phase polymerizations. While not wishing to be bound by theory it is believed that the fouling is initiated by the buildup of static charges in the reactor. The use of anti-static agents mitigates this problem, but typical antistatic agents contain polar species, which can deactivate the polymerization catalyst. We have now discovered that the use of a porous metal oxide support allows large levels of a selected antistatic agent to be used in a manner that reduces static / fouling problems in highly active polymerization catalysts.
Owner:NOVA CHEM (INT) SA +1
Cas9-DNA Targeting Unit Chimeras
ActiveUS20160177278A1High precisionIncrease diversityFusion with DNA-binding domainHydrolasesHuman DNA sequencingDna targeting
The present invention provides a Cas9 platform to facilitate single-site nuclease gene editing precision within a human genome. For example, a Cas9 nuclease / DNA-targeting unit (Cas9-DTU) fusion protein precisely delivers a Cas9 / sgRNA complex to a specific target site within the genome for subsequent sgRNA-dependent cleavage of an adjacent target sequence. Alternatively, attenuating Cas9 binding using mutations to the a protospacer adjacent motif (PAM) recognition domain makes Cas9 target site recognition dependent on the associated DTU, all while retaining Cas9's sgRNA-mediated DNA cleavage fidelity. Cas9-DTU fusion proteins have improved target site binding precision, greater nuclease activity, and a broader sequence targeting range than standard Cas9 systems. Existing Cas9 or sgRNA variants (e.g., truncated sgRNAs (tru-gRNAs), nickases and FokI fusions) are compatible with these improvements to further reduce off-target cleavage. A robust, broadly applicable strategy is disclosed to impart Cas9 genome-editing systems with the single-genomic-site accuracy needed for safe, effective clinical application.
Owner:UNIV OF MASSACHUSETTS
Flow regulator assembly
ActiveUS20100096127A1Operating means/releasing devices for valvesFluid removalSingle siteEngineering
A system for and method of supplying an injection fluid to a well assembly so that the injection fluid flows at a substantially constant flow rate. The fluid can be injected at a single site in the well assembly or multiple sites. A flow control regulator is included that attaches to the well assembly and provides a self adjusting flow control for the fluid being injected. The regulator includes a slidable floating sleeve having an orifice through which the fluid flows. The sleeve includes an inlet port that can register with a fluid supply port to allow the injection fluid to make its way into the sleeve. The fluid exits the sleeve through the orifice to generate a pressure differential across the orifice that in turn exerts a sliding force onto the sleeve. Moving the sleeve misaligns the inlet port and fluid supply port thereby throttling flow through the regulator to a predetermined flow rate.
Owner:BAKER HUGHES INC
Preparation of multimodal polyethylene
Disclosed is a polyethylene composition. The composition comprises single-site multimodal resin A and single-site multimodal resin B, wherein resin A differs from resin B in molecular weight, in monomeric composition, in density, in long chain branch concentration or distribution, or in combinations thereof. Disclosed is also a method for making the polyethylene composition. The method comprises polymerizing, in the presence of two or more single-site catalysts, ethylene or its mixture with a C3-C10 α-olefin to form a first multimodal resin and continuing the polymerization in the presence of the same catalysts but in a different hydrogen concentration, in a different monomer composition, or at a different temperature to form a second multimodal resin.
Owner:EQUSR CHEM LP
Systems and methods for use by an implantable medical device for controlling multi-site CRT pacing in the presence of atrial tachycardia
Owner:PACESETTER INC
Method and apparatus for organizing and playing data
InactiveUS7512622B2Data processing applicationsMultimedia data browsing/visualisationMarine navigationSingle site
The present invention provides a general solution to presenting media interface and navigation tools for content provided from a plurality of sources. The invention maintains a user at a single site regardless of the source of the media content. This permits a consistent interface to be presented to the user. Because the user remains at the same site, differences in tiered membership may be tracked so that the user is only presented with content that the user is permitted to view. The invention uses a metadata language to characterize content so that viewer type, membership level, and other information can be maintained and used for an enjoyable viewing experience.
Owner:VERIZON PATENT & LICENSING INC +1
Film
InactiveUS20100304062A1Easy to processIncrease chanceSynthetic resin layered productsLaminationLow-density polyethyleneLinear low-density polyethylene
The present invention provides a uniaxially oriented multilayer film comprising at least (i) a layer (A) and (ii) a layer (B), wherein said layer (A) comprises a linear low density polyethylene (LLDPE) comprising (e.g. selected from):—a multimodal LLDPE produced using a Ziegler Natta catalyst (znLLDPE), or—a LLDPE produced using a single site catalyst (mLLDPE) or—a mixture of a mLLDPE and a multimodal znLLDPE, said layer (B) comprises a multimodal LLDPE, and said multilayer film is in the form of a stretched film which is uniaxially oriented in the machine direction (MD) in a draw ratio of at least 1:3.
Owner:BOREALIS TECH OY
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