58 results about "Recurrent genital herpes" patented technology

The invention provides the application of the effective fraction of a periplaneta Americana in preparing drugs for inhibiting herpesvirus (HSV) infection and preventing and treating oral ulcer and / or genital herpes. The effective fraction of the periplaneta americana is obtained by extracting fresh or dry periplaneta Americana belonging to the blattidae family with ethanol aqueous solution, purifying with macroporous adsorption resin column, and refining by eluting with ethanol solution. The effective fraction of the periplaneta Americana has distinct HSV inhibitory activity, and can be processed into medicinal preparations or health products for inhibiting HSV infection and preventing and treating related diseases or symptoms.

The invention relates to the technical field of biology, and discloses anti-herpes simplex virus polypeptide and its application. Tests show that the anti-herpes simplex virus polypeptide has a high efficiency inhibition effect to the herpes simplex virus propagation, and the anti-herpes simplex virus polypeptide is used for producing the medicines for treating and preventing diseases related to herpes simplex. The invention provides a medicinal preparation which takes the anti-herpes simplex virus polypeptide as the effective component for treating the herpes caused by the herpes simplex virus, and has a obvious effectiveness for treating herpes, the effective rate for treating herpes simplex, labial herpes and genital herpes can reach to 100%. And the anti-herpes simplex virus polypeptide has low recurrence rate after heal and no toxic side effect.

The present invention belongs to the field of medicine and gene engineering technology, and is especially one kind of polyepitope DNA vaccine resisting herpes virus-2 infection and its preparation process. The present invention connects gB, gC and gD of HSV-2 and the main antigen epitope region plus interval sequence of immediate early protein of ICP27 serially to eukaryotic expression vector pcDNA3.1 to obtain the DNA vaccine HV-pcDNA3.1. The DNA vaccine may be used in preventing and treating HSV-2 infected diseases, such as genital herpes, etc. The DNA vaccine has the features of high specificity, high protection and simple preparation process.

A dermatological composition containing an association of peroxidized lipids; and zinc in mineral form or zinc compound compatible with dermatological use, formulated for topical application on the skin or the mucous membranes, is disclosed compatible with dermatological use. The composition may be used as a medical device to assist in healing and / or reconstitution of a damaged epidermis and / or to act as an analgesic agent on the skin or the mucous membranes, in particular in the treatment of the symptoms of herpes, pruritus, itching, irritations, eczema, burns, and most particularly in the treatment of labial or genital herpes.

The invention discloses a podophyllotoxin preparation formula for external use for the treatment of condyloma acuminatum and genital herpes, a series of formulations and a preparation method, and belongs to the field of pharmacy. The weights or the volumes of all the ingredients of the formula of 100ml of the podophyllotoxin preparation for external use are as follows: 0.5g of podophyllotoxin, 20ml-80ml of main solvent, 1ml-3ml of penetration enhancer 1, 0.5g-2.5g of penetration enhancer 2, 20ml-80ml of cosolvent and 0.03-0.5g of preservative. The podophyllotoxin preparation for external use has the advantages that the types and the amount of excipients and the proportion of main drugs are reasonable, the drug administration is carried out by a liniment, a spray or other formulations which are applicable to the external use, the main drug can be rapidly absorbed by the horny layer and the epidermis, the efficacy is significant, the local toxicity or side effects are small, the skin acute toxicity is very low, and the podophyllotoxin preparation has no irritation and weak allergy and does not hinder the skin normal functions; the podophyllotoxin preparation has no systemic toxicity or side effects, thereby being safe and effective. The preparation prepared by the formula has the advantages of good appearance, moderate viscosity, easy coating, spraying drug administration, feasible process, controllable quality, simple preparation process, and suitability for industrial batch production.

The invention relates to a formula for a traditional Chinese medicine for oral administration, which cures herpes genitalis, and the preparation method thereof. The formula includes the following components: 15.7% of membranous milk vetch root, 11% of American ginseng, 9.8% of large-headed atractylodes rhizome, 6% of rhizoma atractylodis, 6% of prepared rheum officinale, 6% of rhizoma coptidis, 6% of radix isatidis, 6% of dandelion, 6% of radix gentianae, 6% of scorpio, 2% of centipede, 7.5% of salvia miltiorrhiza, 6% of notoginseng and 6% of liquorice; the preparation method comprises the following steps: preparing prepared rheum officinale by adopting the conventional method; pulverizing American ginseng, notoginseng, scorpio and centipede with a 120-mesh sieve; watering and decocting membranous milk vetch root, large-headed atractylodes rhizome, rhizoma atractylodis, prepared rheum officinale, rhizoma coptidis, radix isatidis, dandelion, radix gentianae, salvia miltiorrhiza and liquorice respectively; mixing the filtrate, concentrating into a thick paste body, drying and grinding into fine powder; and mixing the components intensively and packing into the capsules respectively. The formula has the major effects of tonifying Qi, nourishing Yin, promoting blood circulation, removing obstruction in channels, eliminating dampness, and effectively preventing recurrence, and has the advantages of convenient administration, significant curative effect, and great popularization and application values.

A garment that is made in the form of underwear, that provides a protective barrier between sex partners. The garment provides protection from HPV (human papillomavirus), and genital ulcer diseases such as; genital herpes, syphilis, and chanchroid, while making sex possible. The garment is made of both a breathable and non-breathable fabric that prohibits the transfer of sexually transmitted diseases (listed above) by way of an infected partner's skin. The garment in the most basic form is a breathable fabric in the form of underwear that has an additional layer of latex in the crotch area, and openings for the insertion of a penis. The garment is made differently for males and females to address the differing locations of female / male anatomy.

The invention relates to a banga extract and the application in preparing antiviral medicine, which can not only inhibit various etiological agent bacteria, but also can play evident antiviral function through a plurality of connections such as inhibiting virus absorption, directly killing living virus, and inhibiting proliferation of virus, thereby the extract can be applied in preparing medicine which resists bacteria and virus, and simultaneously can be applied in food, health products and cosmetics. The banga extract of the invention can be made into medicine compound in preparing of the medicine which resists bacteria and virus in single-flavor or compound style, in particular to the application of the single-flavor or the compound style in preparing medicine compound for curing genital herpes. Simultaneously, the extract can be used incorporated in food, health products and cosmetics. The banga extract has the advantages of rich raw material, low cost, simple extraction technique, and can be conveniently shaped into various shapes, and has important developing and applying prospect.

The invention relates to an external drug for treating skin diseases, particularly an external ointment for treating skin diseases. The external ointment is prepared by the following steps: (1) taking Sophora flavescens, myrrh, Radix Angelicae dahuricae, Divaricate Saposhnikovia Root, and chrysanthemum, cleaning, carrying out water extraction through boiling water, filtering, condensing the filtrate into a concentrated solution, and making the concentrated solution into first fine powder; (2) taking borneol, musk, calculus bovis, pearl, and calcined calamine, respectively crushing into fine powder, and mixing uniformly to obtain second fine powder; and (3) taking Vaseline and lanolin, heating, filtering out impurities, cooling, adding the first fine powder, second fine powder, polyinosinic-polycytidylic acid and PEG, mixing uniformly until semi-solid to obtain a finished product. The external ointment has the characteristics of warming acrid, relieving exterior syndrome, clearing heat, expelling evil, moving qi, promoting blood circulation, removing blood stasis to produce new, healing sore, relieving pain, resisting virus, raising body immunity, improving blood circulation, promoting regeneration and restoration of tissues, and has good curative effect on herpes simplex, herpes zoster, genital herpes, and refractory sore and ulcer diseases.

The invention discloses a herpes simplex virus type 2 (HSV-2) genetic recombinant attenuated live vaccine and a preparation method thereof. US2, US3, US4 and US5 genes in a genome are knocked out. The method comprises the following steps of: separating and identifying vesicle liquid of a patient who suffers from oral herpes and genital herpes and has obvious vesicles to obtain wild type HSV-1 and HSV-2; performing amplifying culture, and extracting a virus complete genome; transfecting Vero cells by using a shuttle vector containing a fluorescent expressed gene and 700bp to 2,000bp homologous flanking sequences on the left and right sides of an HSV gene which is prepared to be knocked out; and picking recombinant virus out under a fluorescent microscope by using one or more fluorescent protein genes as markers, and performing plaque purification to obtain the needed recombinant attenuated live vaccine. The vaccine effectively induces mucosal and humoral immune response of organisms, so that the morbidity of people is reduced; and cellular immune response is excited, so that the infected virus can be cleared, and the relapse and spreading of herpes are controlled.

The invention discloses a pharmaceutical composition for treating recurrent genital herpes and a preparation method thereof. The pharmaceutical composition is a preparation prepared from astragalus membranaceus, polygonum cuspidatum, calculus bovis factitius, pseudo-ginseng and licorice roots as main raw materials. The traditional Chinese medicine composition has the effects of tonifying qi, activating blood and removing toxins, is obvious in curative effect, safe and free of side effects, and can effectively relieve clinical symptom signs, improve immunity and remarkably reduce long-term recurrence risks. The invention further discloses a preparation method of the pharmaceutical composition, and the pharmaceutical composition is prepared after the raw materials are subjected to crushing or solvent extraction or other pretreatment according to different characteristics of the traditional Chinese medicine raw materials and then mixed in proportion.

The invention discloses a Traditional Chinese medicine composition for treating the recurrent genital herpes and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is formed by an orally-taken medicine composition; the orally-taken medicine composition comprises the following eleven traditional Chinese medicines in parts by weight: 5 to 10 parts of rhizoma atractylodis, 5 to 15 parts of bighead atractylodes rhizome, 5 to 15 parts of poria cocos, 10 to 30 parts of rhizoma smilacis glabrae, 10 to 30 parts of Chinese lobelia, 10 to 30 parts of sculellaria barbata, 10 to 30 parts of radix paeoniae alba, 10 to 30 parts of radix paeoniae rubra, 5 to 15 parts of Chinese thorowax root, 10 to 30 parts of coix seed and 5 to 10 parts of liquorice. The traditional Chinese medicine composition is reasonable in compatibility, has a good treatment effect on the recurrent genital herpes, has the effects of soothing liver and strengthening spleen, clearing away heat, cooling blood and promoting diuresis and has a good clinical curative effect on treating the recurrent genital herpes.

The invention provides a plant extract compound suppository for treating gynecological diseases and a preparation method thereof. The suppository is used for treating coleitis, genital herpes caused by herpes simplex virus II type (HSV-2) and other gynecological diseases. The plant extract compound suppository is prepared by scutellaria baicalensis, rhizoma gastrodiae, Philippine violet herbs, sophora flavescens, common cnidium fruits, radix stemonae, chlorhexidine, surfactant, cosurfactant and others. The plant extract compound suppository is refined in herb and simple in compatibility, effects of the herbs act on one another, treatment bases are sufficient, and the plant extract compound suppository has the advantages of taking effect fast, being safe, free of side and toxic effects and dependency, short in treatment period, low in cost and high in maturity and treating both symptoms and root causes. The suppository contains several effective antibacterial components of the scutellaria baicalensis extract and rhizoma gastrodiae extract, and therefore the product has a good antibacterial effect while treating the diseases and is natural, safe and free of side effects.

The invention discloses a drug for treating recurrent genital herpes and a preparation method thereof. The drug for treating recurrent genital herpes comprises rhizoma atractylodis, fineleaf schizonepeta herb, divaricate saposhnikovia root, isatis root, folium isatidis, poria cocos, coix seed, Chinese yam, bighead atractylodes rhizome, radix pseudostellariae, rheum officinale, baical skullcap root, bark of Chinese corktree, licorice, dahurica angelica root, platycodon root, rehmannia root and cicada slough. The preparation method comprises the following steps of 1, putting the medicinal raw materials into a heating pot, adding water into the heating pot, wherein the weight of the added water is 8 times that of the medicinal raw materials, immersing the medicinal raw materials for 2 hours, boiling for 3 hours, filtering, and collecting the filtrate, 2, adding water into the filter residues until the filter residues are submerged by the water, boiling for 1 hour, filtering, and collecting the filtrate, and 3, merging the filtrate obtained by the step 1 and the step 2, carrying out reduced pressure condensation to obtain extract having a ratio of 1: 1, drying the extract by an oven, crushing the dried extract into fine powder, adding an appropriate amount of dextrin into the fine powder, mixing uniformly to obtain the drug for treating recurrent herpes progenitalis, and packaging by capsules, wherein each 0.5 grams of the drug for treating recurrent herpes progenitalis is put into a 0-type capsule. The drug for treating recurrent herpes progenitalis is suitable for being utilized in an early herpes attack stage, a herpes attack stage and a herpes recovery stage, has clear curative effects, can produce effects directly and fast, realizes simultaneous treatment of principal and subordinate symptoms, realizes a recurrence rate of 0, is safe and convenient and does not have toxic and side effects.

A method for obtaining a new antiviral compound with multiple action against many viruses, comprising modified highly purified yeast RNA, a pharmaceutical composition comprising such RNA, and a method for the treatment and prevention of viral disease comprising administering to a patient a composition comprising an amount effective to ameliorate the symptoms of viral disease of ribonucleic acid. The exogenous modified yeast RNA has a pronounced multiple anti-virus action in a wide range of concentrations. The modified yeast RNA is capable of inhibiting the reproduction of viruses from Orthomyxoviridae, Paramyxovirus, Hepatitis, Herpesviridae families, enterovirus and adenovirus. Also, the modified yeast RNA is capable of inhibiting the reproduction of influenza viruses, hepatitis C virus, genital herpes, human immunodeficiency virus and Coxsackie B virus.

The present invention provides compositions for the prevention and treatment of genital herpes, comprising nucleoside modified m RNAs that encode herpes simplex virus (HSV) glycoproteins, including those involved in virus entry and immune evasion, and methods of use thereof.

The invention relates to a traditional Chinese medicine for treating recurrent genital herpes, which can be used for effectively solving the drug-use problems for treating genital herpes and preventing recurrence. The technical scheme for solving the drug-use problems is that the traditional Chinese medicine for treating recurrent genital herpes is prepared from the following medicines by weight: 25g-35g of prepared rehmannia roots, 10g-15g of American ginsengs, 25g-36g of largehead atractylodes rhizome, 10g-15g of coptis roots, 10g-15g of radix sophorae flavescentis, 10g-15g of prepared rhubarb, 25g-35g of roost of red-rooted salvia, 10g-15g of dandelion, 10g-15g of mints, 10g-15g of curcuma zedoary, 2g-3g of centipede, 10g-15g of red beans, 10g-15g of fructus forsythia seeds, 20g-25g of pine needles and 1g-3g of borneol; the medicines are crushed and pelletized by adopting a conventional method to obtain the traditional Chinese medicine for treating recurrent genital herpes. Traditional Chinese medicine for treating recurrent genital herpes is abundant in materials, easy to produce and prepare, convenient to take and good in effect; moreover, the traditional Chinese medicine has the effects of nourishing yin to reinforce the kidney, clearing away heat and toxic materials, eliminating dampness, promoting blood circulation to remove blood stasis and dredging collaterals to expel toxification, so that the functions of strengthening the body resistance and preventing the toxicity are achieved. Besides, the traditional Chinese medicine can be effectively used for treating the recurrent genital herpes and is an innovation of the medicine for treating the genital herpes.

The invention discloses a medical composition for treating recurred genital herpes and a preparation method of the medical composition. The medical composition is a preparation prepared from main rawmaterials of glossy ganoderma, purslane herbs and pseudo-ginseng. The medical composition disclosed by the invention has the efficacy of supplementing qi, tonifying the kidney, promoting blood circulation and removing toxicity, is precise in treatment effects, low in price and free from side effects, can obviously reduce the recurrence rate of patients suffering from recurred genital herpes 6 months and 12 months after treatment, and can notably reduce the copy number of Latency-associated tranccrpts (LATs) of spinal ganglia of guinea pigs. The invention further discloses the preparation method of the medical composition. According to different characteristics of each traditional Chinese medicine, pretreatment of crushing or solvent extraction and like is performed, and then the medical composition is prepared from the traditional Chinese medicines in proportion.

Vaccine compositions are disclosed for vaccinating a human or animal against herpes simplex virus infections. Also provided are methods of producing vaccines against herpes simplex virus and methods of using such vaccines to prevent or ameliorate herpes simplex virus-associated disease such as genital herpes.

The present invention relates to a combination comprising HSV-1 and HSV-2 binding monoclonal antibodies or fragments thereof and antiviral agents, the pharmaceutical formulations comprising said combination, optionally together with an excipient pharmaceutically acceptable and its use in the prophylaxis and / or treatment of herpes virus infections, including genital herpes, HSV gingivostomatitis and recurrent herpes labialis, herpes simplex encephalitis (HSE), neonatal HSV, HSV disease in the immunocompromised host and HSV keratitis keratoconjunctivitis.

The present invention relates to compositions comprising HSV antigens and methods for their use in the treatment or prevention of asymptomatic and symptomatic herpesvirus infection, or recurrence.

The invention relates to a Chinese traditional preparation, namely a Chinese traditional medicine to be taken orally, which is used for curing recurrent genital herpes. The Chinese traditional medicine is prepared from the following raw materials by weight: 13 to 15 grams of meadowrue root and rhizo, 13 to 15 grams of populus pseudo-simonii and 13 to 15 grams of corallodiscus flabellata, and 20 to 24 grams of stachys palustris L. The Chinese traditional medicine has the characteristics of low cost, convenient preparation, small toxic and side effect, remarkable curative effect, and no easy recurrence.

The invention belongs to the technical field of wet tissues and application thereof and specifically relates to preparation and application of a novel interferon alpha-2b wet tissue. The novel interferon alpha-2b wet tissue provided by the invention comprises medicine liquid and a carrier carrying the medicine liquid, wherein the medicine liquid contains interferon alpha-2b, a protein stabilizer and water, and the mass ratio of the protein stabilizer to interferon alpha-2b is 1: (4-20), preferably 1: (4-10) and more preferably 1: 4. The invention solves the problem of bioactivity of interferon alpha-2b in the interferon alpha-2b wet tissue and creates a wet tissue containing interferon alpha-2b; and furthermore, the wet tissue containing interferon alpha-2b can be applied to auxiliary treatment of viral infection type skin diseases, such as herpes labialis, herpes zoster, genital herpes, genital warts and the like, and can well solve various disadvantages of various conventional methods for treating viral infection type diseases.

There are provided, inter alia, novel stabilized compositions for treating skin conditions wherein a therapeutically effective dosage of sulfur compound is applied which results in healing. The utilized dosage of sulfur compound results in a quicker breakdown of the virus capsid structure, resulting e.g., in faster healing. The dosing regimen to maintain the concentrations of the sulfur containing amino acid at the affected site also helps achieve quicker healing. The formulations and the methods are applicable to a variety of skin conditions including cold sores, herpes, genital herpes and shingles.

A Prunella vulgaris extract with anti-HSV activity, taking Prunella vulgaris ear or powder thereof, adding 10-22 volume times of water, heating and refluxing for extraction 2-4 times, filtering, combining filtrates, concentrating under reduced pressure, and then adding 0.2- 1 volume of ethanol so that the ethanol concentration is 10-50% v / v, and centrifugation after standing at 4°C for 6-24 hours, the obtained precipitate is washed at least twice with 10-50% v / v ethanol, and the precipitate is collected, Ready to dry. The present invention also provides the above-mentioned preparation method and application of the Prunella vulgaris extract of the present invention. The Prunella vulgaris extract provided by the invention has significant anti-HSV effect in vitro and in vivo, its anti-HSV activity in vitro is doubled compared with that of the water extract, and also has a stable inhibitory effect on ACV-resistant HSV clinical strains and drug-resistant strains . At the same time, it has good curative effect on the skin and genital herpes caused by HSV-1 and HSV-2 infection.

The present invention provides compositions for the prevention and treatment of genital herpes, comprising nucleoside modified mRNAs that encode herpes simplex virus (HSV) glycoproteins, including those involved in virus entry and immune evasion, and methods of use thereof.

An antiviral preparation for treating skin includes an alpha hydroxy acid and a source of chlorine dioxide in a waterless ointment base. This antiviral preparation can be manufactured at a low cost, and is very effective in treating topical viral infections, such as cold sores, warts, genital herpes, shingles, and molluscum contagiosum. The antiviral preparation substantially reduces the healing time for cold sores. In addition, one formulation of the antiviral preparation is suitable as a pour-on treatment for burns.