46results about How to "Relapse control" patented technology

The invention belongs to the technical field of biomedicines, and in particular relates to a novel recombinant adenovirus vector bivalent living vaccine for resisting herpes progenitalis caused by herpes simplex virus type 2 infection. By a molecular biology technology, an expression kit for full-length sequences of genes containing herpes simplex virus type 2 glycoprotein B and glycoprotein D, and an expression kit for cell factor interleukin 2 are cloned to an adenovirus vector to form the vaccine. The vaccine is a replication-defective adenovirus vector living vaccine, only can express protective antigens without pathopoiesia after entering a human body, has high safety, and can simulate the wild herpes virus infection characteristic, effectively induce organism mucosal and humoral immune response and cell immune response, reduce the incidence rate of people, remove viruses which have infected people, and control the relapse and spread of herpes.

The invention discloses an application of DUSP21 gene which is used for preparing products for diagnosing liver cancer and medicines for treating the cancer. The DUSP21 gene of the invention can be used as the peculiar marker gene for diagnosing liver cancer, facilitates the diagnosis on the liver cancer to be more accurate and rapid and provides new therapeutic targets and effective medicines for preventing and treating liver cancer.

The invention provides mulberry and tuber fleeceflower root hair growing medicinal tea for treating alopecia and poliosis, and a preparation method and application thereof. The mulberry and tuber fleeceflower root hair growing medicinal tea is prepared from winter mulberry, tuber fleeceflower root, simpleleaf shrub chastetree fruit, skunk bugbane, yerbadetajo herba ecliptae and glossy privet fruit according to a certain weight part. The preparation method comprises the following steps of: packaging the simpleleaf shrub chastetree fruit and the glossy privet fruit with cloth, placing into a container, decocting by adding water, removing dregs and retaining the medicinal liquid; placing the winter mulberry, the tuber fleeceflower root, the skunk bugbane and theyerbadetajo herba ecliptae into the container, decocting by adding water, removing dregs and retaining the medicinal liquid; and finally, combining the medicinal liquid, filtering, adding crystal sugar and boiling to obtain brown medicinal liquid with a slightly sweet and slightly bitter taste, and bottling the brown medicinal liquid to obtain the mulberry and tuber fleeceflower root hair growing medicinal tea. The mulberry and tuber fleeceflower root hair growing medicinal tea has the advantages of scientific formula, obvious curative effect, convenience of use, low price, no toxic or side effect and the like; when using the product, a user drinks 100 milliliters of the tepid medicinal tea in the morning and at night each day; generally, after two weeks, pores are protruded and new hairs grow; furthermore, the mulberry and tuber fleeceflower root hair growing medicinal tea can blacken the hairs and relieve itching as well as control reappearance of alopecia and poliosis.

The invention discloses an application of CXorf41 gene which is used for preparing products for diagnosing liver cancer and medicines for treating the cancer. The CXorf41 gene of the invention can be used as the peculiar marker gene for diagnosing liver cancer, facilitates the diagnosis on the liver cancer to be more accurate and rapid and provides new therapeutic targets and effective medicines for preventing and treating liver cancer.

The invention discloses an application of CXorf41 gene which is used for preparing products for diagnosing liver cancer and medicines for treating the cancer. The CXorf41 gene of the invention can be used as the peculiar marker gene for diagnosing liver cancer, facilitates the diagnosis on the liver cancer to be more accurate and rapid and provides new therapeutic targets and effective medicines for preventing and treating liver cancer.

The invention discloses a rehabilitation medicine, including the ingredients with the following weight percentage: 15-25% of natural pearl, 5-10% of bezoar, 5-15% of sappan wood, 4-12% of Chinese rhubarb, 2-6% of vermilion, 1-4% of musk and 10-15% of herba hyperici japonici. The rehabilitation medicine of the invention can play the roles of eliminating toxicity, treating drug addiction, strengthening the body resistance, consolidating the constitution and treating both manifestation and root cause of disease of Chinese medicines, effectively combine control, aftercare and rehabilitation, and overcome the defects that the traditional similar rehabilitation Chinese medicines only can partially relieve addiction symptoms or has poor early effect, and special people is appointed for nursing and late rehabilitation therapy, thus finishing rehabilitation in one time, reducing the phenomena of relapse and achieving the efficacies of treating both manifestation and root cause of disease.

The invention discloses a herpes simplex virus type 2 (HSV-2) genetic recombinant attenuated live vaccine and a preparation method thereof. US2, US3, US4 and US5 genes in a genome are knocked out. The method comprises the following steps of: separating and identifying vesicle liquid of a patient who suffers from oral herpes and genital herpes and has obvious vesicles to obtain wild type HSV-1 and HSV-2; performing amplifying culture, and extracting a virus complete genome; transfecting Vero cells by using a shuttle vector containing a fluorescent expressed gene and 700bp to 2,000bp homologous flanking sequences on the left and right sides of an HSV gene which is prepared to be knocked out; and picking recombinant virus out under a fluorescent microscope by using one or more fluorescent protein genes as markers, and performing plaque purification to obtain the needed recombinant attenuated live vaccine. The vaccine effectively induces mucosal and humoral immune response of organisms, so that the morbidity of people is reduced; and cellular immune response is excited, so that the infected virus can be cleared, and the relapse and spreading of herpes are controlled.

The invention provides a recombined attenuated live vaccine for preventing and treating I-type or II-type infection of herpes simplex virus and preparation method thereof. The recombined attenuated live vaccine is characterized by omitting the UL43, UL44, UL45, UL46 and UL47 genes in the genome thereof; the method comprises the steps of: separating and identifying a wild-type herpes simplex virus; carrying out enlarged cultivation, extracting the complete genome of the virus, and designing a primer to amplify a homologous flanking sequence formulating the omitted gene segment; cloning the homologous flanking sequence and a fluorescent protein gene to a pShuttle-CMV carrier to carry out homologous recombination; selecting the recombined virus by taking the fluorescent protein gene as a mark; and carrying out plaque purification to obtain the gene-recombined attenuated live vaccine of the herpes simplex virus. The attenuated live vaccine prepared by the invention undergoes gene engineering recombination so that toxicity returning is not easy to happen, and the other biological characteristics of the attenuated live vaccine are similar to those of the wild-type herpes simplex virus.

The invention discloses an application of MAGEA9 gene which is used for preparing products for diagnosing liver cancer and medicines for treating the cancer. The MAGEA9 gene of the invention can be used as the peculiar marker gene for diagnosing liver cancer, facilitates the diagnosis on the liver cancer to be more accurate and rapid and provides new therapeutic targets and effective medicines for preventing and treating liver cancer.

The invention discloses an application of MAGEA9 gene which is used for preparing products for diagnosing liver cancer and medicines for treating the cancer. The MAGEA9 gene of the invention can be used as the peculiar marker gene for diagnosing liver cancer, facilitates the diagnosis on the liver cancer to be more accurate and rapid and provides new therapeutic targets and effective medicines for preventing and treating liver cancer.